A comparative study of intrathecal ketamine as an additive to 0.5% hyperbaric bupivacaine for intrathecal anaesthesia
Background: Spinal anaesthesia with bupivacaine for lower limb and lower abdominal surgeries is limited by the fixed duration of action and cannot be prolonged except with usage of spinal catheters which increase the chance of infection and occurrence of haemodynamic instability when used in high...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-10-01
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| Series: | Journal of Clinical and Scientific Research |
| Subjects: | |
| Online Access: | http://svimstpt.ap.nic.in/jcsr/oct-dec13_files/OA1.pdf |
| _version_ | 1798018919633518592 |
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| author | N. Hemanth S. Geetha Aloka Samantaray M.H. Rao M. Madhusudan |
| author_facet | N. Hemanth S. Geetha Aloka Samantaray M.H. Rao M. Madhusudan |
| author_sort | N. Hemanth |
| collection | DOAJ |
| description | Background: Spinal anaesthesia with bupivacaine for lower limb and lower abdominal surgeries is limited by the fixed
duration of action and cannot be prolonged except with usage of spinal catheters which increase the chance of infection
and occurrence of haemodynamic instability when used in high doses. To minimize the instability in haemodynamics,
several neuraxial adjuvants have been used.
Methods: We carried out a prospective randomized double-blind study in 60 patients posted for lower abdominal and
lower limb surgeries. Patients were divided into two groups of 30 each. Both groups received 3 mL of intrathecal
hyperbaric 0.5% bupivacaine. In addition, ketamine group (Gr K) received ketamine 0.1mg/kg body weight intathecal
(made to total volume of 0.5 mL); saline group (Gr S) received equal volumes of 0.9% normal saline intrathecally. The
onset and duration of sensory and motor blockade and intraoperative haemodynamics were studied.
Results: Addition of ketamine in comparison to saline administration produced significantly earlier onset (5.2±1Vs.
3.4±1; p=0.000), prolonged duration of sensory block (129.7±14.9 Vs. 111.3±11; p=0.000) and long duration of postoperative analgesia (150.8±11.7Vs. 127.8±12.8; p=0.000).
Conclusion: Addition of ketamine to intrathecal hyperbaric bupivacaine provides better intraoperative spinal block
characteristics, stable haemodynamics and longer duration of postoperative analgesia. |
| first_indexed | 2024-04-11T16:32:15Z |
| format | Article |
| id | doaj.art-27d2ae66273840f58514c4793f3dee48 |
| institution | Directory Open Access Journal |
| issn | 2277-5706 2277-8357 |
| language | English |
| last_indexed | 2024-04-11T16:32:15Z |
| publishDate | 2013-10-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Clinical and Scientific Research |
| spelling | doaj.art-27d2ae66273840f58514c4793f3dee482022-12-22T04:13:59ZengWolters Kluwer Medknow PublicationsJournal of Clinical and Scientific Research2277-57062277-83572013-10-0124197202A comparative study of intrathecal ketamine as an additive to 0.5% hyperbaric bupivacaine for intrathecal anaesthesiaN. Hemanth0S. Geetha1Aloka Samantaray2M.H. Rao3M. Madhusudan4Department of Anaesthesiology, Sri Venkateswara Institute of Medical Sciences, TirupatiDepartment of Anaesthesiology, Sri Venkateswara Institute of Medical Sciences, TirupatiDepartment of Anaesthesiology, Sri Venkateswara Institute of Medical Sciences, TirupatiDepartment of Anaesthesiology, Sri Venkateswara Institute of Medical Sciences, TirupatiDepartment of Anaesthesiology, Sri Venkateswara Institute of Medical Sciences, TirupatiBackground: Spinal anaesthesia with bupivacaine for lower limb and lower abdominal surgeries is limited by the fixed duration of action and cannot be prolonged except with usage of spinal catheters which increase the chance of infection and occurrence of haemodynamic instability when used in high doses. To minimize the instability in haemodynamics, several neuraxial adjuvants have been used. Methods: We carried out a prospective randomized double-blind study in 60 patients posted for lower abdominal and lower limb surgeries. Patients were divided into two groups of 30 each. Both groups received 3 mL of intrathecal hyperbaric 0.5% bupivacaine. In addition, ketamine group (Gr K) received ketamine 0.1mg/kg body weight intathecal (made to total volume of 0.5 mL); saline group (Gr S) received equal volumes of 0.9% normal saline intrathecally. The onset and duration of sensory and motor blockade and intraoperative haemodynamics were studied. Results: Addition of ketamine in comparison to saline administration produced significantly earlier onset (5.2±1Vs. 3.4±1; p=0.000), prolonged duration of sensory block (129.7±14.9 Vs. 111.3±11; p=0.000) and long duration of postoperative analgesia (150.8±11.7Vs. 127.8±12.8; p=0.000). Conclusion: Addition of ketamine to intrathecal hyperbaric bupivacaine provides better intraoperative spinal block characteristics, stable haemodynamics and longer duration of postoperative analgesia.http://svimstpt.ap.nic.in/jcsr/oct-dec13_files/OA1.pdfKetamineIntrathecalAdjuvant |
| spellingShingle | N. Hemanth S. Geetha Aloka Samantaray M.H. Rao M. Madhusudan A comparative study of intrathecal ketamine as an additive to 0.5% hyperbaric bupivacaine for intrathecal anaesthesia Journal of Clinical and Scientific Research Ketamine Intrathecal Adjuvant |
| title | A comparative study of intrathecal ketamine as an additive to 0.5% hyperbaric bupivacaine for intrathecal anaesthesia |
| title_full | A comparative study of intrathecal ketamine as an additive to 0.5% hyperbaric bupivacaine for intrathecal anaesthesia |
| title_fullStr | A comparative study of intrathecal ketamine as an additive to 0.5% hyperbaric bupivacaine for intrathecal anaesthesia |
| title_full_unstemmed | A comparative study of intrathecal ketamine as an additive to 0.5% hyperbaric bupivacaine for intrathecal anaesthesia |
| title_short | A comparative study of intrathecal ketamine as an additive to 0.5% hyperbaric bupivacaine for intrathecal anaesthesia |
| title_sort | comparative study of intrathecal ketamine as an additive to 0 5 hyperbaric bupivacaine for intrathecal anaesthesia |
| topic | Ketamine Intrathecal Adjuvant |
| url | http://svimstpt.ap.nic.in/jcsr/oct-dec13_files/OA1.pdf |
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