Inducible MLL-AF9 Expression Drives an AML Program during Human Pluripotent Stem Cell-Derived Hematopoietic Differentiation

Inducible MLL-AF9 Expression Drives an AML Program during Human Pluripotent Stem Cell-Derived Hematopoietic Differentiation

A t(9;11)(p22;q23) translocation produces the MLL-AF9 fusion protein, which is found in up to 25% of de novo AML cases in children. Despite major advances, obtaining a comprehensive understanding of context-dependent MLL-AF9-mediated gene programs during early hematopoiesis is challenging. Here, we...

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Bibliographic Details
Main Authors: Branco M. H. Heuts, Saioa Arza-Apalategi, Sinne G. Alkema, Esther Tijchon, Laura Jussen, Saskia M. Bergevoet, Bert A. van der Reijden, Joost H. A. Martens
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Cells
Subjects:
MLL-AF9
induced pluripotent stem cells (iPSCs)
hematopoiesis
myeloid
differentiation
bioinformatics
Online Access:https://www.mdpi.com/2073-4409/12/8/1195

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