Potent carbonic anhydrase I, II, IX and XII inhibition activity of novel primary benzenesulfonamides incorporating bis-ureido moieties

Potent carbonic anhydrase I, II, IX and XII inhibition activity of novel primary benzenesulfonamides incorporating bis-ureido moieties

A novel series of twelve aromatic bis-ureido-substituted benzenesulfonamides was synthesised by conjugation of aromatic aminobenzenesulfonamides with aromatic bis-isocyanates. The obtained bis-ureido-substituted derivatives were tested against four selected human carbonic anhydrase isoforms (hCA I,...

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Bibliographic Details
Main Authors:	Tuba Tekeli, Suleyman Akocak, Andrea Petreni, Nebih Lolak, Servet Çete, Claudiu T. Supuran
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2023-12-01
Series:	Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:	Bis-ureido carbonic anhydrase sulphonamide isoform-selective inhibitor anticancer agent
Online Access:	https://www.tandfonline.com/doi/10.1080/14756366.2023.2185762

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