The effect of oral administration of Withania somnifera root on formalin-induced pain in diabetic rats
Abstract Introduction: Hyperalgesia is considered as one the marked signs of subchronic diabetes mellitus that could affect the life style of the patients. With c onsidering the potential anti-diabetic effect of the medicinal plant Withania somnifera (WS)( ashwagandha), this study was designed to i...
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| Format: | Article |
| Language: | English |
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Iran University of Medical Sciences
2009-01-01
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| Series: | Basic and Clinical Neuroscience |
| Subjects: | |
| Online Access: | http://bcn.tums.ac.ir/browse.php?a_code=A-10-1-7&slc_lang=en&sid=1 |
| _version_ | 1797282474481418240 |
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| author | Mohsen Khalili |
| author_facet | Mohsen Khalili |
| author_sort | Mohsen Khalili |
| collection | DOAJ |
| description | Abstract Introduction: Hyperalgesia is considered as one the marked signs of subchronic diabetes mellitus that could affect the life style of the patients. With c onsidering the potential anti-diabetic effect of the medicinal plant Withania somnifera (WS)( ashwagandha), this study was designed to investigate the analgesic effect of WS on formalin-induced nociceptive responses (standard formalin test) in diabetic rats. Methods: Rats were divided into control, WS-treated control, diabetic, sodium salicylate (SS)-treated control and diabetic and WS-treated diabetic groups. For induction of diabetes, streptozotocin (STZ) was used at a single dose. The treatment groups received oral administration of ashwagandha -mixed rat pellet (6.25%) for two months. Results: The results showed that diabetic rats exhibited a higher score of pain at both phases of the formalin test and WS-treated diabetic rats exhibited a lower nociceptive score at both phases of the test (p<0.05). Meanwhile, SS administration significantly reduced pain score only at chronic phase of the test in the diabetic group (p<0.01). Discussion: Taken together, these results indicate that two-month administration of ashwagandha could attenuate nociceptive score in an experimental model of diabetes mellitus and this may be considered as a potential treatment for painful diabetic neuropathy. |
| first_indexed | 2024-03-07T17:14:35Z |
| format | Article |
| id | doaj.art-27d5ffdf970a4a62abe1b7682138a50b |
| institution | Directory Open Access Journal |
| issn | 2008-126X 2228-7442 |
| language | English |
| last_indexed | 2024-03-07T17:14:35Z |
| publishDate | 2009-01-01 |
| publisher | Iran University of Medical Sciences |
| record_format | Article |
| series | Basic and Clinical Neuroscience |
| spelling | doaj.art-27d5ffdf970a4a62abe1b7682138a50b2024-03-02T23:28:20ZengIran University of Medical SciencesBasic and Clinical Neuroscience2008-126X2228-74422009-01-01112931The effect of oral administration of Withania somnifera root on formalin-induced pain in diabetic ratsMohsen KhaliliAbstract Introduction: Hyperalgesia is considered as one the marked signs of subchronic diabetes mellitus that could affect the life style of the patients. With c onsidering the potential anti-diabetic effect of the medicinal plant Withania somnifera (WS)( ashwagandha), this study was designed to investigate the analgesic effect of WS on formalin-induced nociceptive responses (standard formalin test) in diabetic rats. Methods: Rats were divided into control, WS-treated control, diabetic, sodium salicylate (SS)-treated control and diabetic and WS-treated diabetic groups. For induction of diabetes, streptozotocin (STZ) was used at a single dose. The treatment groups received oral administration of ashwagandha -mixed rat pellet (6.25%) for two months. Results: The results showed that diabetic rats exhibited a higher score of pain at both phases of the formalin test and WS-treated diabetic rats exhibited a lower nociceptive score at both phases of the test (p<0.05). Meanwhile, SS administration significantly reduced pain score only at chronic phase of the test in the diabetic group (p<0.01). Discussion: Taken together, these results indicate that two-month administration of ashwagandha could attenuate nociceptive score in an experimental model of diabetes mellitus and this may be considered as a potential treatment for painful diabetic neuropathy.http://bcn.tums.ac.ir/browse.php?a_code=A-10-1-7&slc_lang=en&sid=1Withania somniferaAnalgesiaDiabetes mellitusStreptozotocinRat |
| spellingShingle | Mohsen Khalili The effect of oral administration of Withania somnifera root on formalin-induced pain in diabetic rats Basic and Clinical Neuroscience Withania somnifera Analgesia Diabetes mellitus Streptozotocin Rat |
| title | The effect of oral administration of Withania somnifera root on formalin-induced pain in diabetic rats |
| title_full | The effect of oral administration of Withania somnifera root on formalin-induced pain in diabetic rats |
| title_fullStr | The effect of oral administration of Withania somnifera root on formalin-induced pain in diabetic rats |
| title_full_unstemmed | The effect of oral administration of Withania somnifera root on formalin-induced pain in diabetic rats |
| title_short | The effect of oral administration of Withania somnifera root on formalin-induced pain in diabetic rats |
| title_sort | effect of oral administration of withania somnifera root on formalin induced pain in diabetic rats |
| topic | Withania somnifera Analgesia Diabetes mellitus Streptozotocin Rat |
| url | http://bcn.tums.ac.ir/browse.php?a_code=A-10-1-7&slc_lang=en&sid=1 |
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