Combined use of amlodipine and folic acid are significantly more efficacious than amlodipine alone in lowering plasma homocysteine and blood pressure among hypertensive patients with hyperhomocysteinemia and intolerance to ACEI: A multicenter, randomized, double‐blind, parallel‐controlled clinical trial

Combined use of amlodipine and folic acid are significantly more efficacious than amlodipine alone in lowering plasma homocysteine and blood pressure among hypertensive patients with hyperhomocysteinemia and intolerance to ACEI: A multicenter, randomized, double‐blind, parallel‐controlled clinical trial

Abstract Hyperhomocysteinemia with hypertension can synergistically increase the risk of stroke. The China stroke primary prevention trial showed that combining 0.8 mg folic acid (FA) with angiotensin‐converting enzyme inhibitor (ACEI) can effectively lower plasma total homocysteine (tHcy) and blood...

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Bibliographic Details
Main Authors: Huihui Bao, Xiao Huang, Ping Li, Changsheng Sheng, Jin Zhang, Zhirong Wang, Demin Song, Lihua Hu, Congcong Ding, Zaihua Cheng, Chen Yao, Guangliang Chen, Yimin Cui, Xianhui Qin, Genfu Tang, Xiaobin Wang, Yong Huo, Xiaoshu Cheng, Jiguang Wang
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:The Journal of Clinical Hypertension
Subjects:
amlodipine‐folic acid
blood pressure
hypertension with hyperhomocysteinemia
randomized clinical trial
total homocysteine
Online Access:https://doi.org/10.1111/jch.14697

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