Covalent hits and where to find them

Covalent hits and where to find them

Covalent hits for drug discovery campaigns are neither fantastic beasts nor mythical creatures, they can be routinely identified through electrophile-first screening campaigns using a suite of different techniques. These include biophysical and biochemical methods, cellular approaches, and DNA-encod...

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Bibliographic Details
Main Authors: Simon C.C. Lucas, J. Henry Blackwell, Sarah H. Hewitt, Hannah Semple, Benjamin C. Whitehurst, Hua Xu
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:SLAS Discovery
Subjects:
Covalent
Irreversible
Hit identification
Mass spectrometry
DEL
Screening
Online Access:http://www.sciencedirect.com/science/article/pii/S2472555224000042

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