Casual Association Between Coffee Intake and Prostate Cancer Based on Two-sample Mendel Randomization
Objective To assess the causal relationship between coffee intake and prostate cancer risk by using the two-sample Mendel randomization (MR) method. Methods The genome-wide association study (GWAS) data on coffee intake (exposure) and prostate cancer (outcome) were obtained from two independent data...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Magazine House of Cancer Research on Prevention and Treatment
2024-01-01
|
| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2024.23.0672 |
| _version_ | 1797300411656306688 |
|---|---|
| author | CHEN Jinguo WANG Zhishi HUANG Wei |
| author_facet | CHEN Jinguo WANG Zhishi HUANG Wei |
| author_sort | CHEN Jinguo |
| collection | DOAJ |
| description | Objective To assess the causal relationship between coffee intake and prostate cancer risk by using the two-sample Mendel randomization (MR) method. Methods The genome-wide association study (GWAS) data on coffee intake (exposure) and prostate cancer (outcome) were obtained from two independent data sets in UK Biobank. The inverse variance weighted method (IVW), weighted median estimator method (WME), and MR-Egger method were used for MR analyses. The OR value and 95%CI were used to represent the association between coffee intake and prostate cancer. In addition, the MR-Egger method was performed for pleiotropic and heterogeneity tests, and the leave-one-out method was used for sensitivity analysis. Results A total of 38 SNP were selected as instrumental variables. The IVW method showed that coffee intake might reduce the risk of prostate cancer (OR=0.994; 95%CI: 0.990-0.999; P=0.009). The WME method obtained the same conclusions (OR=0.991; 95%CI: 0.985-0.999; P=0.018), but MR-Egger regression did not find a causal relationship between coffee intake and prostate cancer (OR=0.992; 95%CI: 0.983-1.000; P=0.084). The MR-Egger method showed no pleiotropy (intercept=4.2E-5; P=0.581) or heterogeneity (Q=27.20; P=0.854) among the instrumental variables. The sensitivity analysis indicated that the conclusion was robust. Conclusion Two-sample Mendel randomization analysis reveals that coffee consumption might reduce the risk of prostate cancer. |
| first_indexed | 2024-03-07T23:06:48Z |
| format | Article |
| id | doaj.art-27da4a1e106b482d8a73f94df61a935f |
| institution | Directory Open Access Journal |
| issn | 1000-8578 |
| language | zho |
| last_indexed | 2024-03-07T23:06:48Z |
| publishDate | 2024-01-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj.art-27da4a1e106b482d8a73f94df61a935f2024-02-22T02:48:35ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782024-01-01511495410.3971/j.issn.1000-8578.2024.23.06728578.2024.23.0672Casual Association Between Coffee Intake and Prostate Cancer Based on Two-sample Mendel RandomizationCHEN Jinguo0WANG Zhishi1HUANG Wei2Department of Urology, Chinese Medicine Hospital of Hainan Province, Haikou 570203, ChinaDepartment of Urology, Chinese Medicine Hospital of Hainan Province, Haikou 570203, ChinaDepartment of Urology, Chinese Medicine Hospital of Hainan Province, Haikou 570203, ChinaObjective To assess the causal relationship between coffee intake and prostate cancer risk by using the two-sample Mendel randomization (MR) method. Methods The genome-wide association study (GWAS) data on coffee intake (exposure) and prostate cancer (outcome) were obtained from two independent data sets in UK Biobank. The inverse variance weighted method (IVW), weighted median estimator method (WME), and MR-Egger method were used for MR analyses. The OR value and 95%CI were used to represent the association between coffee intake and prostate cancer. In addition, the MR-Egger method was performed for pleiotropic and heterogeneity tests, and the leave-one-out method was used for sensitivity analysis. Results A total of 38 SNP were selected as instrumental variables. The IVW method showed that coffee intake might reduce the risk of prostate cancer (OR=0.994; 95%CI: 0.990-0.999; P=0.009). The WME method obtained the same conclusions (OR=0.991; 95%CI: 0.985-0.999; P=0.018), but MR-Egger regression did not find a causal relationship between coffee intake and prostate cancer (OR=0.992; 95%CI: 0.983-1.000; P=0.084). The MR-Egger method showed no pleiotropy (intercept=4.2E-5; P=0.581) or heterogeneity (Q=27.20; P=0.854) among the instrumental variables. The sensitivity analysis indicated that the conclusion was robust. Conclusion Two-sample Mendel randomization analysis reveals that coffee consumption might reduce the risk of prostate cancer.http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2024.23.0672mendel randomizationcoffeeprostate cancer |
| spellingShingle | CHEN Jinguo WANG Zhishi HUANG Wei Casual Association Between Coffee Intake and Prostate Cancer Based on Two-sample Mendel Randomization Zhongliu Fangzhi Yanjiu mendel randomization coffee prostate cancer |
| title | Casual Association Between Coffee Intake and Prostate Cancer Based on Two-sample Mendel Randomization |
| title_full | Casual Association Between Coffee Intake and Prostate Cancer Based on Two-sample Mendel Randomization |
| title_fullStr | Casual Association Between Coffee Intake and Prostate Cancer Based on Two-sample Mendel Randomization |
| title_full_unstemmed | Casual Association Between Coffee Intake and Prostate Cancer Based on Two-sample Mendel Randomization |
| title_short | Casual Association Between Coffee Intake and Prostate Cancer Based on Two-sample Mendel Randomization |
| title_sort | casual association between coffee intake and prostate cancer based on two sample mendel randomization |
| topic | mendel randomization coffee prostate cancer |
| url | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2024.23.0672 |
| work_keys_str_mv | AT chenjinguo casualassociationbetweencoffeeintakeandprostatecancerbasedontwosamplemendelrandomization AT wangzhishi casualassociationbetweencoffeeintakeandprostatecancerbasedontwosamplemendelrandomization AT huangwei casualassociationbetweencoffeeintakeandprostatecancerbasedontwosamplemendelrandomization |