Preparation of oridonin nanocrystals and study of their endocytosis and transcytosis behaviours on MDCK polarized epithelial cells

Preparation of oridonin nanocrystals and study of their endocytosis and transcytosis behaviours on MDCK polarized epithelial cells

Context Oridonin (ORI) has obvious anticancer effects, but its solubility is poor. Nanocrystal (NC) is a novel nano-drug delivery system for increasing bioavailability for ORI. However, the endocytosis and transcytosis behaviours of oridonin nanocrystals (ORI-NCs) through epithelial membrane are sti...

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Bibliographic Details
Main Authors: Huagang Sheng, Yuanyuan Zhang, Jijuan Nai, Shaohua Wang, Mengmeng Dai, Guitao Lin, Liqiao Zhu, Qiang Zhang
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Pharmaceutical Biology
Subjects:
poor water solubility
bottom-up method
mdck monolayer
transcellular transport
Online Access:http://dx.doi.org/10.1080/13880209.2020.1767160

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