Coronary Artery Bypass Grafting in advance aged patients
INTRODUCTION: This study aimed to assess the impact of coronary artery bypass grafting (CABG) on outcomes in elderly patients compared to younger patients.METHOD: An observational case-control study was conducted involving 535 patients, divided into two groups: older adults (≥75 years) and yo...
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| Format: | Article |
| Language: | English |
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Vesnu Publications
2023-07-01
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| Series: | ARYA Atherosclerosis |
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| Online Access: | https://arya.mui.ac.ir/article_30954_f74cc43d9ec4229e7ce08baa07d74cb8.pdf |
| _version_ | 1827298357557592064 |
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| author | Roxana Sadeghi |
| author_facet | Roxana Sadeghi |
| author_sort | Roxana Sadeghi |
| collection | DOAJ |
| description | INTRODUCTION: This study aimed to assess the impact of coronary artery bypass grafting (CABG) on outcomes in elderly patients compared to younger patients.METHOD: An observational case-control study was conducted involving 535 patients, divided into two groups: older adults (≥75 years) and younger adults (<75 years). All patients underwent CABG following a similar protocol. The primary endpoints focused on early post-procedure outcomes, including in-hospital mortality and the duration of ICU or hospital stay. Patients were followed up for six months, and secondary study endpoints included long-term mortality, left ventricular ejection fraction, re-hospitalization rates, and repeated revascularization.RESULTS: 535 patients who underwent CABG were enrolled in this study. The smoking habit was significantly higher among younger adults (38.2% vs. 12.5%, P=0.001). Hypertension was more prevalent among older adults than younger adults (75% vs. 60%, P=0.044). LDL cholesterol serum levels were higher among younger adult patients (94.9±32.5 vs. 80.9±32.9, P=0.028). In-hospital death was not significantly different between younger and older adults (2.8% vs. 5.0%, P=0.34). Mortality in the six-month follow-up was non-significantly higher in the elderly (2.1% vs. 8.1%, P=0.06).A significant proportion of patients in both groups (46.9% in younger patients vs. 40% in older ones, P=0.40) received dual antiplatelet therapy (DAPT) prior to CABG due to a recent myocardial infarction and receipt of a new stent, but without increased major bleeding in both groups.CONCLUSION: CABG should be considered a viable treatment option for elderly patients with acceptable operative risk in current clinical practice.
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| first_indexed | 2024-04-24T15:13:34Z |
| format | Article |
| id | doaj.art-27ddbcbc22064085946f6bb7dce53c48 |
| institution | Directory Open Access Journal |
| issn | 1735-3955 2251-6638 |
| language | English |
| last_indexed | 2024-04-24T15:13:34Z |
| publishDate | 2023-07-01 |
| publisher | Vesnu Publications |
| record_format | Article |
| series | ARYA Atherosclerosis |
| spelling | doaj.art-27ddbcbc22064085946f6bb7dce53c482024-04-02T09:31:20ZengVesnu PublicationsARYA Atherosclerosis1735-39552251-66382023-07-0119416016810.48305/arya.2023.41535.288430954Coronary Artery Bypass Grafting in advance aged patientsRoxana Sadeghi0Prevention of Cardiovascular Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. INTRODUCTION: This study aimed to assess the impact of coronary artery bypass grafting (CABG) on outcomes in elderly patients compared to younger patients.METHOD: An observational case-control study was conducted involving 535 patients, divided into two groups: older adults (≥75 years) and younger adults (<75 years). All patients underwent CABG following a similar protocol. The primary endpoints focused on early post-procedure outcomes, including in-hospital mortality and the duration of ICU or hospital stay. Patients were followed up for six months, and secondary study endpoints included long-term mortality, left ventricular ejection fraction, re-hospitalization rates, and repeated revascularization.RESULTS: 535 patients who underwent CABG were enrolled in this study. The smoking habit was significantly higher among younger adults (38.2% vs. 12.5%, P=0.001). Hypertension was more prevalent among older adults than younger adults (75% vs. 60%, P=0.044). LDL cholesterol serum levels were higher among younger adult patients (94.9±32.5 vs. 80.9±32.9, P=0.028). In-hospital death was not significantly different between younger and older adults (2.8% vs. 5.0%, P=0.34). Mortality in the six-month follow-up was non-significantly higher in the elderly (2.1% vs. 8.1%, P=0.06).A significant proportion of patients in both groups (46.9% in younger patients vs. 40% in older ones, P=0.40) received dual antiplatelet therapy (DAPT) prior to CABG due to a recent myocardial infarction and receipt of a new stent, but without increased major bleeding in both groups.CONCLUSION: CABG should be considered a viable treatment option for elderly patients with acceptable operative risk in current clinical practice. https://arya.mui.ac.ir/article_30954_f74cc43d9ec4229e7ce08baa07d74cb8.pdfelderlycoronary artery bypass graftingmortalitygastrointestinal bleedingcerebrovascular eventsejection fraction |
| spellingShingle | Roxana Sadeghi Coronary Artery Bypass Grafting in advance aged patients ARYA Atherosclerosis elderly coronary artery bypass grafting mortality gastrointestinal bleeding cerebrovascular events ejection fraction |
| title | Coronary Artery Bypass Grafting in advance aged patients |
| title_full | Coronary Artery Bypass Grafting in advance aged patients |
| title_fullStr | Coronary Artery Bypass Grafting in advance aged patients |
| title_full_unstemmed | Coronary Artery Bypass Grafting in advance aged patients |
| title_short | Coronary Artery Bypass Grafting in advance aged patients |
| title_sort | coronary artery bypass grafting in advance aged patients |
| topic | elderly coronary artery bypass grafting mortality gastrointestinal bleeding cerebrovascular events ejection fraction |
| url | https://arya.mui.ac.ir/article_30954_f74cc43d9ec4229e7ce08baa07d74cb8.pdf |
| work_keys_str_mv | AT roxanasadeghi coronaryarterybypassgraftinginadvanceagedpatients |