Serrated Colorectal Lesions: An Up-to-Date Review from Histological Pattern to Molecular Pathogenesis
Until 2010, colorectal serrated lesions were generally considered as harmless lesions and reported as hyperplastic polyps (HPs) by pathologists and gastroenterologists. However, recent evidence showed that they may bear the potential to develop into colorectal carcinoma (CRC). Therefore, the World H...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/8/4461 |
| _version_ | 1797410675949043712 |
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| author | Martino Mezzapesa Giuseppe Losurdo Francesca Celiberto Salvatore Rizzi Antonio d’Amati Domenico Piscitelli Enzo Ierardi Alfredo Di Leo |
| author_facet | Martino Mezzapesa Giuseppe Losurdo Francesca Celiberto Salvatore Rizzi Antonio d’Amati Domenico Piscitelli Enzo Ierardi Alfredo Di Leo |
| author_sort | Martino Mezzapesa |
| collection | DOAJ |
| description | Until 2010, colorectal serrated lesions were generally considered as harmless lesions and reported as hyperplastic polyps (HPs) by pathologists and gastroenterologists. However, recent evidence showed that they may bear the potential to develop into colorectal carcinoma (CRC). Therefore, the World Health Organization (WHO) classification has identified four categories of serrated lesions: hyperplastic polyps (HPs), sessile serrated lesions (SSLs), traditional serrated adenoma (TSAs) and unclassified serrated adenomas. SSLs with dysplasia and TSAs are the most common precursors of CRC. CRCs arising from serrated lesions originate via two different molecular pathways, namely sporadic microsatellite instability (MSI) and the CpG island methylator phenotype (CIMP), the latter being considered as the major mechanism that drives the serrated pathway towards CRC. Unlike CRCs arising through the adenoma–carcinoma pathway, APC-inactivating mutations are rarely shown in the serrated neoplasia pathway. |
| first_indexed | 2024-03-09T04:33:41Z |
| format | Article |
| id | doaj.art-27de7de166c84840a013e810aa258176 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T04:33:41Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-27de7de166c84840a013e810aa2581762023-12-03T13:31:10ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-04-01238446110.3390/ijms23084461Serrated Colorectal Lesions: An Up-to-Date Review from Histological Pattern to Molecular PathogenesisMartino Mezzapesa0Giuseppe Losurdo1Francesca Celiberto2Salvatore Rizzi3Antonio d’Amati4Domenico Piscitelli5Enzo Ierardi6Alfredo Di Leo7Section of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, ItalySection of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, ItalySection of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, ItalySection of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, ItalySection of Pathology, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, ItalySection of Pathology, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, ItalySection of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, ItalySection of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, ItalyUntil 2010, colorectal serrated lesions were generally considered as harmless lesions and reported as hyperplastic polyps (HPs) by pathologists and gastroenterologists. However, recent evidence showed that they may bear the potential to develop into colorectal carcinoma (CRC). Therefore, the World Health Organization (WHO) classification has identified four categories of serrated lesions: hyperplastic polyps (HPs), sessile serrated lesions (SSLs), traditional serrated adenoma (TSAs) and unclassified serrated adenomas. SSLs with dysplasia and TSAs are the most common precursors of CRC. CRCs arising from serrated lesions originate via two different molecular pathways, namely sporadic microsatellite instability (MSI) and the CpG island methylator phenotype (CIMP), the latter being considered as the major mechanism that drives the serrated pathway towards CRC. Unlike CRCs arising through the adenoma–carcinoma pathway, APC-inactivating mutations are rarely shown in the serrated neoplasia pathway.https://www.mdpi.com/1422-0067/23/8/4461colorectal cancercolorectal serrated lesionssessile serrated lesionsserrated pathwaymicrosatellite instabilityCpG island methylator phenotype |
| spellingShingle | Martino Mezzapesa Giuseppe Losurdo Francesca Celiberto Salvatore Rizzi Antonio d’Amati Domenico Piscitelli Enzo Ierardi Alfredo Di Leo Serrated Colorectal Lesions: An Up-to-Date Review from Histological Pattern to Molecular Pathogenesis International Journal of Molecular Sciences colorectal cancer colorectal serrated lesions sessile serrated lesions serrated pathway microsatellite instability CpG island methylator phenotype |
| title | Serrated Colorectal Lesions: An Up-to-Date Review from Histological Pattern to Molecular Pathogenesis |
| title_full | Serrated Colorectal Lesions: An Up-to-Date Review from Histological Pattern to Molecular Pathogenesis |
| title_fullStr | Serrated Colorectal Lesions: An Up-to-Date Review from Histological Pattern to Molecular Pathogenesis |
| title_full_unstemmed | Serrated Colorectal Lesions: An Up-to-Date Review from Histological Pattern to Molecular Pathogenesis |
| title_short | Serrated Colorectal Lesions: An Up-to-Date Review from Histological Pattern to Molecular Pathogenesis |
| title_sort | serrated colorectal lesions an up to date review from histological pattern to molecular pathogenesis |
| topic | colorectal cancer colorectal serrated lesions sessile serrated lesions serrated pathway microsatellite instability CpG island methylator phenotype |
| url | https://www.mdpi.com/1422-0067/23/8/4461 |
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