Maturation of Corticospinal Tracts in Children With Hemiplegic Cerebral Palsy Assessed by Diffusion Tensor Imaging and Transcranial Magnetic Stimulation
Aim: To assess changes in the developmental trajectory of corticospinal tracts (CST) maturation in children with hemiplegic cerebral palsy (HCP).Methods: Neuroimaging data were obtained from 36 children with HCP for both the more affected (MA) and less affected (LA) hemispheres, and, for purposes of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-07-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnhum.2019.00254/full |
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| author | Christos Papadelis Christos Papadelis Harper Kaye Harper Kaye Benjamin Shore Brian Snyder Patricia Ellen Grant Patricia Ellen Grant Alexander Rotenberg Alexander Rotenberg Alexander Rotenberg |
| author_facet | Christos Papadelis Christos Papadelis Harper Kaye Harper Kaye Benjamin Shore Brian Snyder Patricia Ellen Grant Patricia Ellen Grant Alexander Rotenberg Alexander Rotenberg Alexander Rotenberg |
| author_sort | Christos Papadelis |
| collection | DOAJ |
| description | Aim: To assess changes in the developmental trajectory of corticospinal tracts (CST) maturation in children with hemiplegic cerebral palsy (HCP).Methods: Neuroimaging data were obtained from 36 children with HCP for both the more affected (MA) and less affected (LA) hemispheres, and, for purposes of direct comparison, between groups, 15 typically developing (TD) children. With diffusion tensor imaging (DTI), we estimated the mean fractional anisotropy (FA), axial diffusivity (AD), mean diffusivity (MD), and radial diffusivity (RD) of the corticospinal tract, parameters indicative of factors including myelination and axon density. Transcranial magnetic stimulation (TMS) was performed as a neurophysiologic measure of corticospinal tract integrity and organization. Resting motor threshold (rMT) was obtained per hemisphere, per patient.Results: We observed a significant AD and MD developmental trajectory, both of which were inversely related to age (decrease in AD and diffusivity corresponding to increased age) in both hemispheres of TD children (p < 0.001). This maturation process was absent in both MA and LA hemispheres of children with HCP. Additionally, the TMS-derived previously established rMT developmental trajectory was preserved in the LA hemisphere of children with HCP (n = 26; p < 0.0001) but this trajectory was absent in the MA hemisphere.Conclusions: Corticospinal tract maturation arrests in both hemispheres of children with HCP, possibly reflecting perinatal disruption of corticospinal tract myelination and axonal integrity. |
| first_indexed | 2024-12-20T19:53:33Z |
| format | Article |
| id | doaj.art-27df14395c9042eebfef89964b401b16 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-20T19:53:33Z |
| publishDate | 2019-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-27df14395c9042eebfef89964b401b162022-12-21T19:28:13ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612019-07-011310.3389/fnhum.2019.00254456962Maturation of Corticospinal Tracts in Children With Hemiplegic Cerebral Palsy Assessed by Diffusion Tensor Imaging and Transcranial Magnetic StimulationChristos Papadelis0Christos Papadelis1Harper Kaye2Harper Kaye3Benjamin Shore4Brian Snyder5Patricia Ellen Grant6Patricia Ellen Grant7Alexander Rotenberg8Alexander Rotenberg9Alexander Rotenberg10Laboratory of Children’s Brain Dynamics, Division of Newborn Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA, United StatesFetal-Neonatal Neuroimaging and Developmental Science Center, Division of Newborn Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA, United StatesNeuromodulation Program, Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children’s Hospital, Boston, MA, United StatesF.M. Kirby Neurobiology Center, Boston Children’s Hospital, Boston, MA, United StatesDepartment of Orthopedic Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, MA, United StatesDepartment of Orthopedic Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, MA, United StatesFetal-Neonatal Neuroimaging and Developmental Science Center, Division of Newborn Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA, United StatesDepartment of Radiology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, United StatesNeuromodulation Program, Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children’s Hospital, Boston, MA, United StatesF.M. Kirby Neurobiology Center, Boston Children’s Hospital, Boston, MA, United StatesDepartment of Neurology, Berenson-Allen Center for Noninvasive Brain Stimulation, Division of Cognitive Neurology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, United StatesAim: To assess changes in the developmental trajectory of corticospinal tracts (CST) maturation in children with hemiplegic cerebral palsy (HCP).Methods: Neuroimaging data were obtained from 36 children with HCP for both the more affected (MA) and less affected (LA) hemispheres, and, for purposes of direct comparison, between groups, 15 typically developing (TD) children. With diffusion tensor imaging (DTI), we estimated the mean fractional anisotropy (FA), axial diffusivity (AD), mean diffusivity (MD), and radial diffusivity (RD) of the corticospinal tract, parameters indicative of factors including myelination and axon density. Transcranial magnetic stimulation (TMS) was performed as a neurophysiologic measure of corticospinal tract integrity and organization. Resting motor threshold (rMT) was obtained per hemisphere, per patient.Results: We observed a significant AD and MD developmental trajectory, both of which were inversely related to age (decrease in AD and diffusivity corresponding to increased age) in both hemispheres of TD children (p < 0.001). This maturation process was absent in both MA and LA hemispheres of children with HCP. Additionally, the TMS-derived previously established rMT developmental trajectory was preserved in the LA hemisphere of children with HCP (n = 26; p < 0.0001) but this trajectory was absent in the MA hemisphere.Conclusions: Corticospinal tract maturation arrests in both hemispheres of children with HCP, possibly reflecting perinatal disruption of corticospinal tract myelination and axonal integrity.https://www.frontiersin.org/article/10.3389/fnhum.2019.00254/fullhemiplegic cerebral palsycorticospinal tractsdevelopmentmaturationtranscranial magnetic stimulation |
| spellingShingle | Christos Papadelis Christos Papadelis Harper Kaye Harper Kaye Benjamin Shore Brian Snyder Patricia Ellen Grant Patricia Ellen Grant Alexander Rotenberg Alexander Rotenberg Alexander Rotenberg Maturation of Corticospinal Tracts in Children With Hemiplegic Cerebral Palsy Assessed by Diffusion Tensor Imaging and Transcranial Magnetic Stimulation Frontiers in Human Neuroscience hemiplegic cerebral palsy corticospinal tracts development maturation transcranial magnetic stimulation |
| title | Maturation of Corticospinal Tracts in Children With Hemiplegic Cerebral Palsy Assessed by Diffusion Tensor Imaging and Transcranial Magnetic Stimulation |
| title_full | Maturation of Corticospinal Tracts in Children With Hemiplegic Cerebral Palsy Assessed by Diffusion Tensor Imaging and Transcranial Magnetic Stimulation |
| title_fullStr | Maturation of Corticospinal Tracts in Children With Hemiplegic Cerebral Palsy Assessed by Diffusion Tensor Imaging and Transcranial Magnetic Stimulation |
| title_full_unstemmed | Maturation of Corticospinal Tracts in Children With Hemiplegic Cerebral Palsy Assessed by Diffusion Tensor Imaging and Transcranial Magnetic Stimulation |
| title_short | Maturation of Corticospinal Tracts in Children With Hemiplegic Cerebral Palsy Assessed by Diffusion Tensor Imaging and Transcranial Magnetic Stimulation |
| title_sort | maturation of corticospinal tracts in children with hemiplegic cerebral palsy assessed by diffusion tensor imaging and transcranial magnetic stimulation |
| topic | hemiplegic cerebral palsy corticospinal tracts development maturation transcranial magnetic stimulation |
| url | https://www.frontiersin.org/article/10.3389/fnhum.2019.00254/full |
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