Superior prognostic value of right ventricular free wall compared to global longitudinal strain in patients with repaired tetralogy of Fallot
ObjectivesBoth right ventricular free wall longitudinal strain (RVFWLS) and right ventricular global longitudinal strain (RVGLS) using two-dimensional speckle tracking echocardiography (2D-STE) has been demonstrated to predict adverse outcomes in patients with repaired tetralogy of Fallot (r-TOF). H...
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.996398/full |
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| author | Ying Gao Ying Gao Ying Gao Ying Gao He Li He Li He Li Lin He Lin He Lin He Yanting Zhang Yanting Zhang Yanting Zhang Wei Sun Wei Sun Wei Sun Meng Li Lang Gao Lang Gao Lang Gao Yixia Lin Yixia Lin Yixia Lin Mengmeng Ji Mengmeng Ji Mengmeng Ji Qing Lv Qing Lv Qing Lv Jing Wang Jing Wang Jing Wang Li Zhang Li Zhang Li Zhang Mingxing Xie Mingxing Xie Mingxing Xie Yuman Li Yuman Li Yuman Li |
| author_facet | Ying Gao Ying Gao Ying Gao Ying Gao He Li He Li He Li Lin He Lin He Lin He Yanting Zhang Yanting Zhang Yanting Zhang Wei Sun Wei Sun Wei Sun Meng Li Lang Gao Lang Gao Lang Gao Yixia Lin Yixia Lin Yixia Lin Mengmeng Ji Mengmeng Ji Mengmeng Ji Qing Lv Qing Lv Qing Lv Jing Wang Jing Wang Jing Wang Li Zhang Li Zhang Li Zhang Mingxing Xie Mingxing Xie Mingxing Xie Yuman Li Yuman Li Yuman Li |
| author_sort | Ying Gao |
| collection | DOAJ |
| description | ObjectivesBoth right ventricular free wall longitudinal strain (RVFWLS) and right ventricular global longitudinal strain (RVGLS) using two-dimensional speckle tracking echocardiography (2D-STE) has been demonstrated to predict adverse outcomes in patients with repaired tetralogy of Fallot (r-TOF). However, RVGLS may be affected by left ventricular (LV) function owing to the fact that the interventricular septum is also a part of the left ventricle. Therefore, the aim of our study was to compare the predictive value of RVFWLS with that of RVGLS in patients with r-TOF.Materials and methodsA total of 179 patients with r-TOF were included in this study. RVFWLS, RVGLS, and left ventricle global longitudinal strain (LVGLS) were evaluated by 2D-STE. The adverse clinical events were death or r-TOF-related rehospitalization. Prognostic performance was evaluated by C-statistic and Akaike information criterion (AIC).ResultsThirty-one patients developed poor outcomes during a median follow-up period of 2.8 years. Compared with patients without end-point events, those with end-point events had higher incidence of moderate/severe pulmonary regurgitation, larger right heart sizes, and lower RV fractional area change (RVFAC), RVFWLS, RVGLS, and LVGLS than those without. Multivariate Cox regression analysis revealed that RVFAC, RVFWLS, RVGLS, and LVGLS were predictive of poor outcomes in patients with r-TOF after adjustment for transannular patch and QRS duration. A Cox model using RVFWLS (C index = 0.876, AIC = 228) was found to predict unfavorable outcomes more accurately than a model with RVGLS (C index = 0.856, AIC = 243), RVFAC (C index = 0.811, AIC = 248), and LVGLS (C index = 0.830, AIC = 248).ConclusionAlthough both RVGLS and RVFWLS are associated with adverse events, RVFWLS provides superior prognostic value than that of RVGLS in patients with r-TOF. |
| first_indexed | 2024-04-14T07:24:18Z |
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| language | English |
| last_indexed | 2024-04-14T07:24:18Z |
| publishDate | 2022-09-01 |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-27df278db0024c64908a3d319562973e2022-12-22T02:06:03ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-09-01910.3389/fcvm.2022.996398996398Superior prognostic value of right ventricular free wall compared to global longitudinal strain in patients with repaired tetralogy of FallotYing Gao0Ying Gao1Ying Gao2Ying Gao3He Li4He Li5He Li6Lin He7Lin He8Lin He9Yanting Zhang10Yanting Zhang11Yanting Zhang12Wei Sun13Wei Sun14Wei Sun15Meng Li16Lang Gao17Lang Gao18Lang Gao19Yixia Lin20Yixia Lin21Yixia Lin22Mengmeng Ji23Mengmeng Ji24Mengmeng Ji25Qing Lv26Qing Lv27Qing Lv28Jing Wang29Jing Wang30Jing Wang31Li Zhang32Li Zhang33Li Zhang34Mingxing Xie35Mingxing Xie36Mingxing Xie37Yuman Li38Yuman Li39Yuman Li40Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Ultrasound in Medicine, Shanghai Institute of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaClinical Research Center for Medical Imaging in Hubei Province, Wuhan, ChinaDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaClinical Research Center for Medical Imaging in Hubei Province, Wuhan, ChinaDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaClinical Research Center for Medical Imaging in Hubei Province, Wuhan, ChinaDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaClinical Research Center for Medical Imaging in Hubei Province, Wuhan, ChinaDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaClinical Research Center for Medical Imaging in Hubei Province, Wuhan, ChinaDepartment of Ultrasound in Medicine, Shanghai Institute of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, ChinaDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaClinical Research Center for Medical Imaging in Hubei Province, Wuhan, ChinaDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaClinical Research Center for Medical Imaging in Hubei Province, Wuhan, ChinaDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaClinical Research Center for Medical Imaging in Hubei Province, Wuhan, ChinaDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaClinical Research Center for Medical Imaging in Hubei Province, Wuhan, ChinaDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaClinical Research Center for Medical Imaging in Hubei Province, Wuhan, ChinaDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaClinical Research Center for Medical Imaging in Hubei Province, Wuhan, ChinaDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaClinical Research Center for Medical Imaging in Hubei Province, Wuhan, ChinaDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaClinical Research Center for Medical Imaging in Hubei Province, Wuhan, ChinaObjectivesBoth right ventricular free wall longitudinal strain (RVFWLS) and right ventricular global longitudinal strain (RVGLS) using two-dimensional speckle tracking echocardiography (2D-STE) has been demonstrated to predict adverse outcomes in patients with repaired tetralogy of Fallot (r-TOF). However, RVGLS may be affected by left ventricular (LV) function owing to the fact that the interventricular septum is also a part of the left ventricle. Therefore, the aim of our study was to compare the predictive value of RVFWLS with that of RVGLS in patients with r-TOF.Materials and methodsA total of 179 patients with r-TOF were included in this study. RVFWLS, RVGLS, and left ventricle global longitudinal strain (LVGLS) were evaluated by 2D-STE. The adverse clinical events were death or r-TOF-related rehospitalization. Prognostic performance was evaluated by C-statistic and Akaike information criterion (AIC).ResultsThirty-one patients developed poor outcomes during a median follow-up period of 2.8 years. Compared with patients without end-point events, those with end-point events had higher incidence of moderate/severe pulmonary regurgitation, larger right heart sizes, and lower RV fractional area change (RVFAC), RVFWLS, RVGLS, and LVGLS than those without. Multivariate Cox regression analysis revealed that RVFAC, RVFWLS, RVGLS, and LVGLS were predictive of poor outcomes in patients with r-TOF after adjustment for transannular patch and QRS duration. A Cox model using RVFWLS (C index = 0.876, AIC = 228) was found to predict unfavorable outcomes more accurately than a model with RVGLS (C index = 0.856, AIC = 243), RVFAC (C index = 0.811, AIC = 248), and LVGLS (C index = 0.830, AIC = 248).ConclusionAlthough both RVGLS and RVFWLS are associated with adverse events, RVFWLS provides superior prognostic value than that of RVGLS in patients with r-TOF.https://www.frontiersin.org/articles/10.3389/fcvm.2022.996398/fulltetralogy of Fallotspeckle tracking echocardiographyoutcomeright ventricular functionstrain |
| spellingShingle | Ying Gao Ying Gao Ying Gao Ying Gao He Li He Li He Li Lin He Lin He Lin He Yanting Zhang Yanting Zhang Yanting Zhang Wei Sun Wei Sun Wei Sun Meng Li Lang Gao Lang Gao Lang Gao Yixia Lin Yixia Lin Yixia Lin Mengmeng Ji Mengmeng Ji Mengmeng Ji Qing Lv Qing Lv Qing Lv Jing Wang Jing Wang Jing Wang Li Zhang Li Zhang Li Zhang Mingxing Xie Mingxing Xie Mingxing Xie Yuman Li Yuman Li Yuman Li Superior prognostic value of right ventricular free wall compared to global longitudinal strain in patients with repaired tetralogy of Fallot Frontiers in Cardiovascular Medicine tetralogy of Fallot speckle tracking echocardiography outcome right ventricular function strain |
| title | Superior prognostic value of right ventricular free wall compared to global longitudinal strain in patients with repaired tetralogy of Fallot |
| title_full | Superior prognostic value of right ventricular free wall compared to global longitudinal strain in patients with repaired tetralogy of Fallot |
| title_fullStr | Superior prognostic value of right ventricular free wall compared to global longitudinal strain in patients with repaired tetralogy of Fallot |
| title_full_unstemmed | Superior prognostic value of right ventricular free wall compared to global longitudinal strain in patients with repaired tetralogy of Fallot |
| title_short | Superior prognostic value of right ventricular free wall compared to global longitudinal strain in patients with repaired tetralogy of Fallot |
| title_sort | superior prognostic value of right ventricular free wall compared to global longitudinal strain in patients with repaired tetralogy of fallot |
| topic | tetralogy of Fallot speckle tracking echocardiography outcome right ventricular function strain |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.996398/full |
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