A Scoping Review on COVID-19-Induced Cardiovascular Complications
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a type of human coronavirus that resulted in the 2019 coronavirus disease (COVID-19). Although it was generally categorized as a respiratory disease, its involvement in cardiovascular complications was identified from the onset. Elevate...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | COVID |
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| Online Access: | https://www.mdpi.com/2673-8112/3/3/26 |
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| author | Ian Osoro Manisha Vohra Mohammad Amir Puneet Kumar Amit Sharma |
| author_facet | Ian Osoro Manisha Vohra Mohammad Amir Puneet Kumar Amit Sharma |
| author_sort | Ian Osoro |
| collection | DOAJ |
| description | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a type of human coronavirus that resulted in the 2019 coronavirus disease (COVID-19). Although it was generally categorized as a respiratory disease, its involvement in cardiovascular complications was identified from the onset. Elevated cardiac troponin levels (a myocardial injury marker) and echocardiograms, which showed the anomalous performance of the patients’ hearts, were noted in the early case reports obtained from Wuhan, China. A couple of mechanisms have been proposed to explain COVID-19-induced cardiovascular complications, with systemic inflammation being the major focus recently. Chest pain and palpitations are among the prevalent symptoms in moderate to severe COVID-19-recovering patients. Cardiac damage potentially occurs due to multifactorial factors, which include cytokine-induced inflammation, direct cardiotoxicity, and disseminated intravascular coagulation (DIC), among others. The cardiovascular manifestations include cardiac arrhythmia, cardiogenic shock, venous thromboembolism, and elevated cardiac biomarkers. Both the long- and short-term effects of these cardiovascular complications remain puzzling to researchers, as substantial evidence is yet to be gathered to reach a consensus on the severity of COVID-19 in the heart. The treatment considerations currently include antiarrhythmic management, ACEI or ARB use, anticoagulation, hemodynamic support, and immunosuppression. This review aimed to outline the pathogenesis of the various cardiac complications due to COVID-19 as well as the available treatment modalities of COVID-19 infection. Both the mechanisms and the treatments have been succinctly explained in a proper manner to ensure understanding. |
| first_indexed | 2024-03-11T06:42:32Z |
| format | Article |
| id | doaj.art-27e084ef06ef40ce9a52080d72e27391 |
| institution | Directory Open Access Journal |
| issn | 2673-8112 |
| language | English |
| last_indexed | 2024-03-11T06:42:32Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | COVID |
| spelling | doaj.art-27e084ef06ef40ce9a52080d72e273912023-11-17T10:27:25ZengMDPI AGCOVID2673-81122023-03-013334836910.3390/covid3030026A Scoping Review on COVID-19-Induced Cardiovascular ComplicationsIan Osoro0Manisha Vohra1Mohammad Amir2Puneet Kumar3Amit Sharma4Department of Pharmacy Practice, ISF College of Pharmacy, Moga 142001, Punjab, IndiaDepartment of Pharmacy Practice, ISF College of Pharmacy, Moga 142001, Punjab, IndiaDepartment of Pharmacy Practice, ISF College of Pharmacy, Moga 142001, Punjab, IndiaDepartment of Pharmacology, Central University of Punjab, Ghudda 151401, Punjab, IndiaDepartment of Pharmacy Practice, ISF College of Pharmacy, Moga 142001, Punjab, IndiaSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a type of human coronavirus that resulted in the 2019 coronavirus disease (COVID-19). Although it was generally categorized as a respiratory disease, its involvement in cardiovascular complications was identified from the onset. Elevated cardiac troponin levels (a myocardial injury marker) and echocardiograms, which showed the anomalous performance of the patients’ hearts, were noted in the early case reports obtained from Wuhan, China. A couple of mechanisms have been proposed to explain COVID-19-induced cardiovascular complications, with systemic inflammation being the major focus recently. Chest pain and palpitations are among the prevalent symptoms in moderate to severe COVID-19-recovering patients. Cardiac damage potentially occurs due to multifactorial factors, which include cytokine-induced inflammation, direct cardiotoxicity, and disseminated intravascular coagulation (DIC), among others. The cardiovascular manifestations include cardiac arrhythmia, cardiogenic shock, venous thromboembolism, and elevated cardiac biomarkers. Both the long- and short-term effects of these cardiovascular complications remain puzzling to researchers, as substantial evidence is yet to be gathered to reach a consensus on the severity of COVID-19 in the heart. The treatment considerations currently include antiarrhythmic management, ACEI or ARB use, anticoagulation, hemodynamic support, and immunosuppression. This review aimed to outline the pathogenesis of the various cardiac complications due to COVID-19 as well as the available treatment modalities of COVID-19 infection. Both the mechanisms and the treatments have been succinctly explained in a proper manner to ensure understanding.https://www.mdpi.com/2673-8112/3/3/26SARS-CoV-2cardiovascular complicationsACE-2 receptorsmyocardial injuryCOVID-19cardiomyocytes |
| spellingShingle | Ian Osoro Manisha Vohra Mohammad Amir Puneet Kumar Amit Sharma A Scoping Review on COVID-19-Induced Cardiovascular Complications COVID SARS-CoV-2 cardiovascular complications ACE-2 receptors myocardial injury COVID-19 cardiomyocytes |
| title | A Scoping Review on COVID-19-Induced Cardiovascular Complications |
| title_full | A Scoping Review on COVID-19-Induced Cardiovascular Complications |
| title_fullStr | A Scoping Review on COVID-19-Induced Cardiovascular Complications |
| title_full_unstemmed | A Scoping Review on COVID-19-Induced Cardiovascular Complications |
| title_short | A Scoping Review on COVID-19-Induced Cardiovascular Complications |
| title_sort | scoping review on covid 19 induced cardiovascular complications |
| topic | SARS-CoV-2 cardiovascular complications ACE-2 receptors myocardial injury COVID-19 cardiomyocytes |
| url | https://www.mdpi.com/2673-8112/3/3/26 |
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