Antimicrobial activity of fusidic acid inclusion complexes
Objectives: To synthesize and characterize the inclusion complexes of fusidic acid with β – cyclodextrin, followed by the evaluation of their antimicrobial activity against pure strain (Staphylococcus aureus ATCC 25,923) and isolated Staphylococcus from clinical cases. Methods: The desired compounds...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-12-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971220321810 |
| _version_ | 1818603692868239360 |
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| author | Eleonora Marian Bogdan Tita Narcis Duteanu Laura Vicas Stefania Ciocan Tunde Jurca Liana Antal Otilia Tica Mariana Mureşan Annamaria Pallag Otilia Micle |
| author_facet | Eleonora Marian Bogdan Tita Narcis Duteanu Laura Vicas Stefania Ciocan Tunde Jurca Liana Antal Otilia Tica Mariana Mureşan Annamaria Pallag Otilia Micle |
| author_sort | Eleonora Marian |
| collection | DOAJ |
| description | Objectives: To synthesize and characterize the inclusion complexes of fusidic acid with β – cyclodextrin, followed by the evaluation of their antimicrobial activity against pure strain (Staphylococcus aureus ATCC 25,923) and isolated Staphylococcus from clinical cases. Methods: The desired compounds were synthesized using molar ratio of fusidic acid: β-cyclodextrin of 1:1. Synthesized compounds were analyzed by Fourier Transform Infrared Spectroscopy (FTIR), X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), and Thermal Analysis, and the results confirmed the formation of inclusion compounds by fusidic acid with β-cyclodextrin. Results: Physical–chemical characterization confirmed the preparation of desired inclusion compounds, and the antimicrobial test confirmed that all compounds obtained have antimicrobial activity. Antimicrobial activity of freeze-drying complex againstS. aureus is similar with pure fusidic acid activity, being better than the cefoxitin one. Similar behavior was observed against methicillin-resistant S. aureus and S. epidermidis. Conclusions: In the present work, three different inclusion complexes of fusidic acid were prepared using three different preparation methods. All inclusion complexes obtained presented good antimicrobial activity against differentS. aureus strains. Antimicrobial activity of these new prepared compounds was observed to be better than that of cefoxitin. |
| first_indexed | 2024-12-16T13:27:13Z |
| format | Article |
| id | doaj.art-27e09d5ca37046278fabf3d0b432d816 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-16T13:27:13Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-27e09d5ca37046278fabf3d0b432d8162022-12-21T22:30:12ZengElsevierInternational Journal of Infectious Diseases1201-97122020-12-011016573Antimicrobial activity of fusidic acid inclusion complexesEleonora Marian0Bogdan Tita1Narcis Duteanu2Laura Vicas3Stefania Ciocan4Tunde Jurca5Liana Antal6Otilia Tica7Mariana Mureşan8Annamaria Pallag9Otilia Micle10University of Oradea, Medicine and Pharmacy Faculty, Piata 1 Decembrie, 410028, Oradea, RomaniaVasile Goldis” Western University of Arad, Pharmacy Faculty, 86 Liviu Rebreanu Street, 310045, Arad, RomaniaUniversity Politehnica of Timisoara, Faculty of Industrial Chemistry and Environmental Engineering, 2 Victoria Square, 300006, Timisoara, Romania; Corresponding authors.University of Oradea, Medicine and Pharmacy Faculty, Piata 1 Decembrie, 410028, Oradea, RomaniaUniversity Politehnica of Timisoara, Faculty of Industrial Chemistry and Environmental Engineering, 2 Victoria Square, 300006, Timisoara, RomaniaUniversity of Oradea, Medicine and Pharmacy Faculty, Piata 1 Decembrie, 410028, Oradea, RomaniaUniversity of Oradea, Medicine and Pharmacy Faculty, Piata 1 Decembrie, 410028, Oradea, Romania; Corresponding authors.University of Oradea, Medicine and Pharmacy Faculty, Piata 1 Decembrie, 410028, Oradea, RomaniaUniversity of Oradea, Medicine and Pharmacy Faculty, Piata 1 Decembrie, 410028, Oradea, RomaniaUniversity of Oradea, Medicine and Pharmacy Faculty, Piata 1 Decembrie, 410028, Oradea, RomaniaUniversity of Oradea, Medicine and Pharmacy Faculty, Piata 1 Decembrie, 410028, Oradea, RomaniaObjectives: To synthesize and characterize the inclusion complexes of fusidic acid with β – cyclodextrin, followed by the evaluation of their antimicrobial activity against pure strain (Staphylococcus aureus ATCC 25,923) and isolated Staphylococcus from clinical cases. Methods: The desired compounds were synthesized using molar ratio of fusidic acid: β-cyclodextrin of 1:1. Synthesized compounds were analyzed by Fourier Transform Infrared Spectroscopy (FTIR), X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), and Thermal Analysis, and the results confirmed the formation of inclusion compounds by fusidic acid with β-cyclodextrin. Results: Physical–chemical characterization confirmed the preparation of desired inclusion compounds, and the antimicrobial test confirmed that all compounds obtained have antimicrobial activity. Antimicrobial activity of freeze-drying complex againstS. aureus is similar with pure fusidic acid activity, being better than the cefoxitin one. Similar behavior was observed against methicillin-resistant S. aureus and S. epidermidis. Conclusions: In the present work, three different inclusion complexes of fusidic acid were prepared using three different preparation methods. All inclusion complexes obtained presented good antimicrobial activity against differentS. aureus strains. Antimicrobial activity of these new prepared compounds was observed to be better than that of cefoxitin.http://www.sciencedirect.com/science/article/pii/S1201971220321810Fusidic acidCyclodextrinCompounds characterizationAntimicrobial activity |
| spellingShingle | Eleonora Marian Bogdan Tita Narcis Duteanu Laura Vicas Stefania Ciocan Tunde Jurca Liana Antal Otilia Tica Mariana Mureşan Annamaria Pallag Otilia Micle Antimicrobial activity of fusidic acid inclusion complexes International Journal of Infectious Diseases Fusidic acid Cyclodextrin Compounds characterization Antimicrobial activity |
| title | Antimicrobial activity of fusidic acid inclusion complexes |
| title_full | Antimicrobial activity of fusidic acid inclusion complexes |
| title_fullStr | Antimicrobial activity of fusidic acid inclusion complexes |
| title_full_unstemmed | Antimicrobial activity of fusidic acid inclusion complexes |
| title_short | Antimicrobial activity of fusidic acid inclusion complexes |
| title_sort | antimicrobial activity of fusidic acid inclusion complexes |
| topic | Fusidic acid Cyclodextrin Compounds characterization Antimicrobial activity |
| url | http://www.sciencedirect.com/science/article/pii/S1201971220321810 |
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