Novel agents and regimens in acute myeloid leukemia: latest updates from 2022 ASH Annual Meeting
Abstract Developments in investigational agents and novel regimens in acute myeloid leukemia (AML) were reported in the 2022 American Society of Hematology (ASH) annual meeting. Encouraging efficacy data were presented from first-in-human studies of two investigational menin inhibitors, SNDX-5613 an...
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | Journal of Hematology & Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13045-023-01411-x |
| _version_ | 1797863790825439232 |
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| author | Katherine W. DiNardo Thomas W. LeBlanc Hui Chen |
| author_facet | Katherine W. DiNardo Thomas W. LeBlanc Hui Chen |
| author_sort | Katherine W. DiNardo |
| collection | DOAJ |
| description | Abstract Developments in investigational agents and novel regimens in acute myeloid leukemia (AML) were reported in the 2022 American Society of Hematology (ASH) annual meeting. Encouraging efficacy data were presented from first-in-human studies of two investigational menin inhibitors, SNDX-5613 and KO-539, in relapsed and refractory (R/R) acute myeloid leukemia (AML) with KMT2A rearrangement or mutant NPM1, with overall response rates (ORR) of 53% (32/60) and 40% (8/20), respectively. The addition of the novel drug pivekimab sunirine, a first-in-class antibody–drug conjugate targeting CD123, to azacitidine and venetoclax in R/R AML resulted in an ORR of 45% (41/91), which rose to 53% in those who were venetoclax naïve. Additional novel triplet treatment combinations included the addition of magrolimab, an anti-CD47 antibody, to azacitidine and venetoclax, with an ORR of 81% (35/43) in newly diagnosed AML, including an ORR of 74% (20/27) in TP53 mutated AML. The addition of the FLT3 inhibitor gilteritinib to azacitidine/venetoclax was also featured, with an ORR of 100% (27/27) in newly diagnosed AML and an ORR of 70% (14/20) in R/R AML. |
| first_indexed | 2024-04-09T22:41:17Z |
| format | Article |
| id | doaj.art-27e1115377e84fc48bd4d7947d9a3ada |
| institution | Directory Open Access Journal |
| issn | 1756-8722 |
| language | English |
| last_indexed | 2024-04-09T22:41:17Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Hematology & Oncology |
| spelling | doaj.art-27e1115377e84fc48bd4d7947d9a3ada2023-03-22T12:07:46ZengBMCJournal of Hematology & Oncology1756-87222023-03-011611310.1186/s13045-023-01411-xNovel agents and regimens in acute myeloid leukemia: latest updates from 2022 ASH Annual MeetingKatherine W. DiNardo0Thomas W. LeBlanc1Hui Chen2Duke University School of MedicineDuke University School of MedicineDuke University School of MedicineAbstract Developments in investigational agents and novel regimens in acute myeloid leukemia (AML) were reported in the 2022 American Society of Hematology (ASH) annual meeting. Encouraging efficacy data were presented from first-in-human studies of two investigational menin inhibitors, SNDX-5613 and KO-539, in relapsed and refractory (R/R) acute myeloid leukemia (AML) with KMT2A rearrangement or mutant NPM1, with overall response rates (ORR) of 53% (32/60) and 40% (8/20), respectively. The addition of the novel drug pivekimab sunirine, a first-in-class antibody–drug conjugate targeting CD123, to azacitidine and venetoclax in R/R AML resulted in an ORR of 45% (41/91), which rose to 53% in those who were venetoclax naïve. Additional novel triplet treatment combinations included the addition of magrolimab, an anti-CD47 antibody, to azacitidine and venetoclax, with an ORR of 81% (35/43) in newly diagnosed AML, including an ORR of 74% (20/27) in TP53 mutated AML. The addition of the FLT3 inhibitor gilteritinib to azacitidine/venetoclax was also featured, with an ORR of 100% (27/27) in newly diagnosed AML and an ORR of 70% (14/20) in R/R AML.https://doi.org/10.1186/s13045-023-01411-xAcute myeloid leukemiaAMLInvestigational therapiesClinical research |
| spellingShingle | Katherine W. DiNardo Thomas W. LeBlanc Hui Chen Novel agents and regimens in acute myeloid leukemia: latest updates from 2022 ASH Annual Meeting Journal of Hematology & Oncology Acute myeloid leukemia AML Investigational therapies Clinical research |
| title | Novel agents and regimens in acute myeloid leukemia: latest updates from 2022 ASH Annual Meeting |
| title_full | Novel agents and regimens in acute myeloid leukemia: latest updates from 2022 ASH Annual Meeting |
| title_fullStr | Novel agents and regimens in acute myeloid leukemia: latest updates from 2022 ASH Annual Meeting |
| title_full_unstemmed | Novel agents and regimens in acute myeloid leukemia: latest updates from 2022 ASH Annual Meeting |
| title_short | Novel agents and regimens in acute myeloid leukemia: latest updates from 2022 ASH Annual Meeting |
| title_sort | novel agents and regimens in acute myeloid leukemia latest updates from 2022 ash annual meeting |
| topic | Acute myeloid leukemia AML Investigational therapies Clinical research |
| url | https://doi.org/10.1186/s13045-023-01411-x |
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