MiR-544 promotes immune escape through downregulation of NCR1/NKp46 via targeting RUNX3 in liver cancer

MiR-544 promotes immune escape through downregulation of NCR1/NKp46 via targeting RUNX3 in liver cancer

Abstract Objective To study the potential role of miR-544 in the immune escape mechanism of hepatoma cells. Methods Natural killer (NK) cells were collected from healthy volunteers and patients with liver cancer. Interleukin (IL)-2 activated-NK-92 cells were transfected with miR-544 inhibitor/mimic...

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Bibliographic Details
Main Authors: Chenwei Pan, Luxia Xiang, Zhenzhen Pan, Xiaodong Wang, Jie Li, Lu Zhuge, Peipei Fang, Qipeng Xie, Xuezhen Hu
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Cancer Cell International
Subjects:
miR-544
RUNX3
NCR1
NK cells
Immune escape
Online Access:http://link.springer.com/article/10.1186/s12935-018-0542-y

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