Mitochondria Clumping vs. Mitochondria Fusion in CMT2A Diseases

Mitochondria Clumping vs. Mitochondria Fusion in CMT2A Diseases

Phenotypic variations in Charcot-Marie-Tooth disease type 2A (CMT2A) result from the many mutations in the mitochondrial fusion protein, mitofusin 2 (MFN2). While the GTPase domain mutations of MFN2 lack the ability to hydrolyze GTP and complete mitochondrial fusion, the mechanism of dysfunction in...

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Bibliographic Details
Main Authors:	Antonietta Franco, Caroline E. Walton, Xiawei Dang
Format:	Article
Language:	English
Published:	MDPI AG 2022-12-01
Series:	Life
Subjects:	mitochondria fitness mitochondria fusion defects mitofusin 2 Charcot-Marie-Tooth disease type 2A
Online Access:	https://www.mdpi.com/2075-1729/12/12/2110

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