Biology and Model Predictions of the Dynamics and Heterogeneity of Chromatin-Nuclear Lamina Interactions
Associations of chromatin with the nuclear lamina, at the nuclear periphery, help shape the genome in 3 dimensions. The genomic landscape of lamina-associated domains (LADs) is well characterized, but much remains unknown on the physical and mechanistic properties of chromatin conformation at the nu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.913458/full |
| _version_ | 1828340655615639552 |
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| author | Julia Madsen-Østerbye Aurélie Bellanger Natalia M. Galigniana Natalia M. Galigniana Philippe Collas Philippe Collas |
| author_facet | Julia Madsen-Østerbye Aurélie Bellanger Natalia M. Galigniana Natalia M. Galigniana Philippe Collas Philippe Collas |
| author_sort | Julia Madsen-Østerbye |
| collection | DOAJ |
| description | Associations of chromatin with the nuclear lamina, at the nuclear periphery, help shape the genome in 3 dimensions. The genomic landscape of lamina-associated domains (LADs) is well characterized, but much remains unknown on the physical and mechanistic properties of chromatin conformation at the nuclear lamina. Computational models of chromatin folding at, and interactions with, a surface representing the nuclear lamina are emerging in attempts to characterize these properties and predict chromatin behavior at the lamina in health and disease. Here, we highlight the heterogeneous nature of the nuclear lamina and LADs, outline the main 3-dimensional chromatin structural modeling methods, review applications of modeling chromatin-lamina interactions and discuss biological insights inferred from these models in normal and disease states. Lastly, we address perspectives on future developments in modeling chromatin interactions with the nuclear lamina. |
| first_indexed | 2024-04-13T22:59:18Z |
| format | Article |
| id | doaj.art-27e6db7f375e4de5881ac55c0b51329c |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-13T22:59:18Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-27e6db7f375e4de5881ac55c0b51329c2022-12-22T02:25:53ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-05-011010.3389/fcell.2022.913458913458Biology and Model Predictions of the Dynamics and Heterogeneity of Chromatin-Nuclear Lamina InteractionsJulia Madsen-Østerbye0Aurélie Bellanger1Natalia M. Galigniana2Natalia M. Galigniana3Philippe Collas4Philippe Collas5Department of Molecular Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, NorwayDepartment of Molecular Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, NorwayDepartment of Molecular Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, NorwayDepartment of Immunology and Transfusion Medicine, Oslo University Hospital, Oslo, NorwayDepartment of Molecular Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, NorwayDepartment of Immunology and Transfusion Medicine, Oslo University Hospital, Oslo, NorwayAssociations of chromatin with the nuclear lamina, at the nuclear periphery, help shape the genome in 3 dimensions. The genomic landscape of lamina-associated domains (LADs) is well characterized, but much remains unknown on the physical and mechanistic properties of chromatin conformation at the nuclear lamina. Computational models of chromatin folding at, and interactions with, a surface representing the nuclear lamina are emerging in attempts to characterize these properties and predict chromatin behavior at the lamina in health and disease. Here, we highlight the heterogeneous nature of the nuclear lamina and LADs, outline the main 3-dimensional chromatin structural modeling methods, review applications of modeling chromatin-lamina interactions and discuss biological insights inferred from these models in normal and disease states. Lastly, we address perspectives on future developments in modeling chromatin interactions with the nuclear lamina.https://www.frontiersin.org/articles/10.3389/fcell.2022.913458/fullchromatininteractionLADlamina-associated domainnuclear envelopepolymer modeling |
| spellingShingle | Julia Madsen-Østerbye Aurélie Bellanger Natalia M. Galigniana Natalia M. Galigniana Philippe Collas Philippe Collas Biology and Model Predictions of the Dynamics and Heterogeneity of Chromatin-Nuclear Lamina Interactions Frontiers in Cell and Developmental Biology chromatin interaction LAD lamina-associated domain nuclear envelope polymer modeling |
| title | Biology and Model Predictions of the Dynamics and Heterogeneity of Chromatin-Nuclear Lamina Interactions |
| title_full | Biology and Model Predictions of the Dynamics and Heterogeneity of Chromatin-Nuclear Lamina Interactions |
| title_fullStr | Biology and Model Predictions of the Dynamics and Heterogeneity of Chromatin-Nuclear Lamina Interactions |
| title_full_unstemmed | Biology and Model Predictions of the Dynamics and Heterogeneity of Chromatin-Nuclear Lamina Interactions |
| title_short | Biology and Model Predictions of the Dynamics and Heterogeneity of Chromatin-Nuclear Lamina Interactions |
| title_sort | biology and model predictions of the dynamics and heterogeneity of chromatin nuclear lamina interactions |
| topic | chromatin interaction LAD lamina-associated domain nuclear envelope polymer modeling |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.913458/full |
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