A study of the smooth muscle relaxant actions of harman alkaloids isolated from the seeds of peganum harmala
Introduction: The plant Peganum harmala is a shrub native to the arid parts of the world including India. It’s therapeutic value is attributed to the presence of alkaloids harmala and harmine in the dried ripe seeds. In traditional medicine these seeds are considered to have anti-spasmodic, hyp...
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| Format: | Article |
| Language: | English |
| Published: |
Prathima Institute of Medical Sciences
2018-12-01
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| Series: | Perspectives In Medical Research |
| Subjects: | |
| Online Access: | http://www.pimr.org.in/rajkumar-vol-6-issue-3-2018.PDF |
| _version_ | 1827642676505214976 |
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| author | Rajkumar T1 , Devde R2 |
| author_facet | Rajkumar T1 , Devde R2 |
| author_sort | Rajkumar T1 , Devde R2 |
| collection | DOAJ |
| description | Introduction: The plant Peganum harmala is a shrub
native to the arid parts of the world including India. It’s
therapeutic value is attributed to the presence of alkaloids
harmala and harmine in the dried ripe seeds. In traditional
medicine these seeds are considered to have anti-spasmodic,
hypnotic, anodyne, emetic, emmenogogue, stimulant,
aphrodisiac, lactogogue and antihelminthic actions.
Objectives: The present study was undertaken to find
out the effects of the active principle extracted from the seeds
of Peganum harmala on isolated smooth muscle and skeletal
muscle preparations and the probable mechanism of action
Materials & Methods: The harman alkaloid isolated
from Peganum harmala seeds was used for experiments on
isolated preparations of rat uterus, guinea pig ileum, rabbit
jejunum and frog rectus abdominis muscles and the responses
were recorded on a rotating smoked drum on a kymograph.
Results: The active principle in Peganum harmala seeds
was shown to inhibit spontaneous movements of isolated rat
uterus, guinea pig ileum and rabbit jejunum. Also shown to
inhibit contractions of oestranised rat uterus induced by
oxytocin, contractions of guinea pig ileum induced by histamine
and acetyl choline. Have not shown any effect on contractions
of frog rectus abdominus muscle.
Conclusion: Harman alkaloids have anti-spasmodic,
tocolytic, anti-cholinergic and anti-histaminic activities, it is
unlikely that these alkaloids have a specific receptor
antagonistic activity. Also these have found to inhibit the
smooth muscle contractions but not the skeletal muscle
contractions. The smooth muscle relaxant action may be due
to calcium channel blockade |
| first_indexed | 2024-03-09T17:36:31Z |
| format | Article |
| id | doaj.art-27e7de9dbee242d29dd2c94b074066e9 |
| institution | Directory Open Access Journal |
| issn | 2348-1447 2348-229X |
| language | English |
| last_indexed | 2024-03-09T17:36:31Z |
| publishDate | 2018-12-01 |
| publisher | Prathima Institute of Medical Sciences |
| record_format | Article |
| series | Perspectives In Medical Research |
| spelling | doaj.art-27e7de9dbee242d29dd2c94b074066e92023-11-24T11:52:43ZengPrathima Institute of Medical SciencesPerspectives In Medical Research2348-14472348-229X2018-12-01632427A study of the smooth muscle relaxant actions of harman alkaloids isolated from the seeds of peganum harmalaRajkumar T1 , Devde R20Kakatiya Medical collegeIntroduction: The plant Peganum harmala is a shrub native to the arid parts of the world including India. It’s therapeutic value is attributed to the presence of alkaloids harmala and harmine in the dried ripe seeds. In traditional medicine these seeds are considered to have anti-spasmodic, hypnotic, anodyne, emetic, emmenogogue, stimulant, aphrodisiac, lactogogue and antihelminthic actions. Objectives: The present study was undertaken to find out the effects of the active principle extracted from the seeds of Peganum harmala on isolated smooth muscle and skeletal muscle preparations and the probable mechanism of action Materials & Methods: The harman alkaloid isolated from Peganum harmala seeds was used for experiments on isolated preparations of rat uterus, guinea pig ileum, rabbit jejunum and frog rectus abdominis muscles and the responses were recorded on a rotating smoked drum on a kymograph. Results: The active principle in Peganum harmala seeds was shown to inhibit spontaneous movements of isolated rat uterus, guinea pig ileum and rabbit jejunum. Also shown to inhibit contractions of oestranised rat uterus induced by oxytocin, contractions of guinea pig ileum induced by histamine and acetyl choline. Have not shown any effect on contractions of frog rectus abdominus muscle. Conclusion: Harman alkaloids have anti-spasmodic, tocolytic, anti-cholinergic and anti-histaminic activities, it is unlikely that these alkaloids have a specific receptor antagonistic activity. Also these have found to inhibit the smooth muscle contractions but not the skeletal muscle contractions. The smooth muscle relaxant action may be due to calcium channel blockadehttp://www.pimr.org.in/rajkumar-vol-6-issue-3-2018.PDFharman alkaloidssmooth musclerelaxant |
| spellingShingle | Rajkumar T1 , Devde R2 A study of the smooth muscle relaxant actions of harman alkaloids isolated from the seeds of peganum harmala Perspectives In Medical Research harman alkaloids smooth muscle relaxant |
| title | A study of the smooth muscle relaxant actions of harman alkaloids isolated from the seeds of peganum harmala |
| title_full | A study of the smooth muscle relaxant actions of harman alkaloids isolated from the seeds of peganum harmala |
| title_fullStr | A study of the smooth muscle relaxant actions of harman alkaloids isolated from the seeds of peganum harmala |
| title_full_unstemmed | A study of the smooth muscle relaxant actions of harman alkaloids isolated from the seeds of peganum harmala |
| title_short | A study of the smooth muscle relaxant actions of harman alkaloids isolated from the seeds of peganum harmala |
| title_sort | study of the smooth muscle relaxant actions of harman alkaloids isolated from the seeds of peganum harmala |
| topic | harman alkaloids smooth muscle relaxant |
| url | http://www.pimr.org.in/rajkumar-vol-6-issue-3-2018.PDF |
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