The Human Microbiome and Its Role in Musculoskeletal Disorders
Musculoskeletal diseases (MSDs) are characterized as injuries and illnesses that affect the musculoskeletal system. MSDs affect every population worldwide and are associated with substantial global burden. Variations in the makeup of the gut microbiota may be related to chronic MSDs. There is growin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/14/10/1937 |
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| author | Khaled Aboushaala Arnold Y. L. Wong Juan Nicolas Barajas Perry Lim Lena Al-Harthi Ana Chee Christopher B. Forsyth Chun-do Oh Sheila J. Toro Frances M. K. Williams Howard S. An Dino Samartzis |
| author_facet | Khaled Aboushaala Arnold Y. L. Wong Juan Nicolas Barajas Perry Lim Lena Al-Harthi Ana Chee Christopher B. Forsyth Chun-do Oh Sheila J. Toro Frances M. K. Williams Howard S. An Dino Samartzis |
| author_sort | Khaled Aboushaala |
| collection | DOAJ |
| description | Musculoskeletal diseases (MSDs) are characterized as injuries and illnesses that affect the musculoskeletal system. MSDs affect every population worldwide and are associated with substantial global burden. Variations in the makeup of the gut microbiota may be related to chronic MSDs. There is growing interest in exploring potential connections between chronic MSDs and variations in the composition of gut microbiota. The human microbiota is a complex community consisting of viruses, archaea, bacteria, and eukaryotes, both inside and outside of the human body. These microorganisms play crucial roles in influencing human physiology, impacting metabolic and immunological systems in health and disease. Different body areas host specific types of microorganisms, with facultative anaerobes dominating the gastrointestinal tract (able to thrive with or without oxygen), while strict aerobes prevail in the nasal cavity, respiratory tract, and skin surfaces (requiring oxygen for development). Together with the immune system, these bacteria have coevolved throughout time, forming complex biological relationships. Changes in the microbial ecology of the gut may have a big impact on health and can help illnesses develop. These changes are frequently impacted by lifestyle choices and underlying medical disorders. The potential for safety, expenses, and efficacy of microbiota-based medicines, even with occasional delivery, has attracted interest. They are, therefore, a desirable candidate for treating MSDs that are chronic and that may have variable progression patterns. As such, the following is a narrative review to address the role of the human microbiome as it relates to MSDs. |
| first_indexed | 2024-03-11T10:14:31Z |
| format | Article |
| id | doaj.art-27e8a408239f4e9a8859946a3aedd225 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-11T10:14:31Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-27e8a408239f4e9a8859946a3aedd2252023-11-16T10:29:51ZengMDPI AGGenes2073-44252023-10-011410193710.3390/genes14101937The Human Microbiome and Its Role in Musculoskeletal DisordersKhaled Aboushaala0Arnold Y. L. Wong1Juan Nicolas Barajas2Perry Lim3Lena Al-Harthi4Ana Chee5Christopher B. Forsyth6Chun-do Oh7Sheila J. Toro8Frances M. K. Williams9Howard S. An10Dino Samartzis11Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USADepartment of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, ChinaDepartment of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USADepartment of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USADepartment of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL 60612, USADepartment of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USADepartment of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USADepartment of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USADepartment of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USADepartment of Twin Research, King’s College London, London WC2R 2LS, UKDepartment of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USADepartment of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USAMusculoskeletal diseases (MSDs) are characterized as injuries and illnesses that affect the musculoskeletal system. MSDs affect every population worldwide and are associated with substantial global burden. Variations in the makeup of the gut microbiota may be related to chronic MSDs. There is growing interest in exploring potential connections between chronic MSDs and variations in the composition of gut microbiota. The human microbiota is a complex community consisting of viruses, archaea, bacteria, and eukaryotes, both inside and outside of the human body. These microorganisms play crucial roles in influencing human physiology, impacting metabolic and immunological systems in health and disease. Different body areas host specific types of microorganisms, with facultative anaerobes dominating the gastrointestinal tract (able to thrive with or without oxygen), while strict aerobes prevail in the nasal cavity, respiratory tract, and skin surfaces (requiring oxygen for development). Together with the immune system, these bacteria have coevolved throughout time, forming complex biological relationships. Changes in the microbial ecology of the gut may have a big impact on health and can help illnesses develop. These changes are frequently impacted by lifestyle choices and underlying medical disorders. The potential for safety, expenses, and efficacy of microbiota-based medicines, even with occasional delivery, has attracted interest. They are, therefore, a desirable candidate for treating MSDs that are chronic and that may have variable progression patterns. As such, the following is a narrative review to address the role of the human microbiome as it relates to MSDs.https://www.mdpi.com/2073-4425/14/10/1937microbiomemusculoskeletalgastrointestinaltherapeuticsimmune systemdisc degeneration |
| spellingShingle | Khaled Aboushaala Arnold Y. L. Wong Juan Nicolas Barajas Perry Lim Lena Al-Harthi Ana Chee Christopher B. Forsyth Chun-do Oh Sheila J. Toro Frances M. K. Williams Howard S. An Dino Samartzis The Human Microbiome and Its Role in Musculoskeletal Disorders Genes microbiome musculoskeletal gastrointestinal therapeutics immune system disc degeneration |
| title | The Human Microbiome and Its Role in Musculoskeletal Disorders |
| title_full | The Human Microbiome and Its Role in Musculoskeletal Disorders |
| title_fullStr | The Human Microbiome and Its Role in Musculoskeletal Disorders |
| title_full_unstemmed | The Human Microbiome and Its Role in Musculoskeletal Disorders |
| title_short | The Human Microbiome and Its Role in Musculoskeletal Disorders |
| title_sort | human microbiome and its role in musculoskeletal disorders |
| topic | microbiome musculoskeletal gastrointestinal therapeutics immune system disc degeneration |
| url | https://www.mdpi.com/2073-4425/14/10/1937 |
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