Clinical spectrum of elderly-onset inflammatory bowel disease in India
Background/Aims Inflammatory bowel disease (IBD) is increasingly being recognized in elderly patients. Data on clinical spectrum of elderly-onset IBD patients is lacking from India. Methods A cross-sectional retrospective analysis of a prospectively maintained database of patients diagnosed with IBD...
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| Format: | Article |
| Language: | English |
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Korean Association for the Study of Intestinal Diseases
2023-04-01
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| Series: | Intestinal Research |
| Subjects: | |
| Online Access: | http://irjournal.org/upload/pdf/ir-2021-00177.pdf |
| _version_ | 1797833533789569024 |
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| author | Yogesh Kumar Gupta Arshdeep Singh Vikram Narang Vandana Midha Ramit Mahajan Varun Mehta Dharmatma Singh Namita Bansal Madeline Vithya Barnaba Durairaj Amit Kumar Dutta Ajit Sood |
| author_facet | Yogesh Kumar Gupta Arshdeep Singh Vikram Narang Vandana Midha Ramit Mahajan Varun Mehta Dharmatma Singh Namita Bansal Madeline Vithya Barnaba Durairaj Amit Kumar Dutta Ajit Sood |
| author_sort | Yogesh Kumar Gupta |
| collection | DOAJ |
| description | Background/Aims Inflammatory bowel disease (IBD) is increasingly being recognized in elderly patients. Data on clinical spectrum of elderly-onset IBD patients is lacking from India. Methods A cross-sectional retrospective analysis of a prospectively maintained database of patients diagnosed with IBD was conducted at 2 centers in India. The clinical spectrum of elderly-onset IBD including demographic profile (age and sex), clinical presentation, disease characteristics (disease behavior and severity, extent of disease), and treatment were recorded and compared with adult-onset IBD. Results During the study period, 3,922 (3,172 ulcerative colitis [UC] and 750 Crohn’s disease [CD]) patients with IBD were recorded in the database. A total of 186 patients (4.74%; 116 males [62.36%]) had elderly-onset IBD (69.35% UC and 30.64% CD). Diarrhea, blood in stools, nocturnal frequency and pain abdomen were the commonest presentations for UC, whereas pain abdomen, weight loss and diarrhea were the most frequent symptoms in CD. For both elderly onset UC and CD, majority of the patients had moderately severe disease. Left-sided colitis was the commonest disease location in UC. Isolated ileal disease and inflammatory behavior were the most common disease location and behavior, respectively in CD. 5-Aminosalicylates were the commonest prescribed drug for both elderly onset UC and CD. Thiopurines and biologics were used infrequently. Prevalence of colorectal cancer was higher in elderly onset IBD. Conclusions Elderly onset IBD is not uncommon in India. Both the elderly onset UC and CD were milder, with no significant differences in disease characteristics (disease extent, location and behavior) when compared to adult-onset IBD. Colorectal cancer was more common in elderly onset IBD. |
| first_indexed | 2024-04-09T14:24:44Z |
| format | Article |
| id | doaj.art-27e9413c803d455cb1f4cc98cfede7f4 |
| institution | Directory Open Access Journal |
| issn | 1598-9100 2288-1956 |
| language | English |
| last_indexed | 2024-04-09T14:24:44Z |
| publishDate | 2023-04-01 |
| publisher | Korean Association for the Study of Intestinal Diseases |
| record_format | Article |
| series | Intestinal Research |
| spelling | doaj.art-27e9413c803d455cb1f4cc98cfede7f42023-05-04T06:27:21ZengKorean Association for the Study of Intestinal DiseasesIntestinal Research1598-91002288-19562023-04-0121221622510.5217/ir.2021.00177976Clinical spectrum of elderly-onset inflammatory bowel disease in IndiaYogesh Kumar Gupta0Arshdeep Singh1Vikram Narang2Vandana Midha3Ramit Mahajan4Varun Mehta5Dharmatma Singh6Namita Bansal7Madeline Vithya Barnaba Durairaj8Amit Kumar Dutta9Ajit Sood10 Department of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, India Department of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, India Department of Pathology, Dayanand Medical College and Hospital, Ludhiana, India Department of Internal Medicine, Dayanand Medical College and Hospital, Ludhiana, India Department of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, India Department of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, India Departmentsof Research and Development Center, Dayanand Medical College and Hospital, Ludhiana, India Departmentsof Research and Development Center, Dayanand Medical College and Hospital, Ludhiana, India Department of Gastroenterology, Christian Medical College and Hospital, Vellore, India Department of Gastroenterology, Christian Medical College and Hospital, Vellore, India Department of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, IndiaBackground/Aims Inflammatory bowel disease (IBD) is increasingly being recognized in elderly patients. Data on clinical spectrum of elderly-onset IBD patients is lacking from India. Methods A cross-sectional retrospective analysis of a prospectively maintained database of patients diagnosed with IBD was conducted at 2 centers in India. The clinical spectrum of elderly-onset IBD including demographic profile (age and sex), clinical presentation, disease characteristics (disease behavior and severity, extent of disease), and treatment were recorded and compared with adult-onset IBD. Results During the study period, 3,922 (3,172 ulcerative colitis [UC] and 750 Crohn’s disease [CD]) patients with IBD were recorded in the database. A total of 186 patients (4.74%; 116 males [62.36%]) had elderly-onset IBD (69.35% UC and 30.64% CD). Diarrhea, blood in stools, nocturnal frequency and pain abdomen were the commonest presentations for UC, whereas pain abdomen, weight loss and diarrhea were the most frequent symptoms in CD. For both elderly onset UC and CD, majority of the patients had moderately severe disease. Left-sided colitis was the commonest disease location in UC. Isolated ileal disease and inflammatory behavior were the most common disease location and behavior, respectively in CD. 5-Aminosalicylates were the commonest prescribed drug for both elderly onset UC and CD. Thiopurines and biologics were used infrequently. Prevalence of colorectal cancer was higher in elderly onset IBD. Conclusions Elderly onset IBD is not uncommon in India. Both the elderly onset UC and CD were milder, with no significant differences in disease characteristics (disease extent, location and behavior) when compared to adult-onset IBD. Colorectal cancer was more common in elderly onset IBD.http://irjournal.org/upload/pdf/ir-2021-00177.pdfcrohn diseasecolitis, ulcerativeinflammatory bowel diseaseselderlyaged |
| spellingShingle | Yogesh Kumar Gupta Arshdeep Singh Vikram Narang Vandana Midha Ramit Mahajan Varun Mehta Dharmatma Singh Namita Bansal Madeline Vithya Barnaba Durairaj Amit Kumar Dutta Ajit Sood Clinical spectrum of elderly-onset inflammatory bowel disease in India Intestinal Research crohn disease colitis, ulcerative inflammatory bowel diseases elderly aged |
| title | Clinical spectrum of elderly-onset inflammatory bowel disease in India |
| title_full | Clinical spectrum of elderly-onset inflammatory bowel disease in India |
| title_fullStr | Clinical spectrum of elderly-onset inflammatory bowel disease in India |
| title_full_unstemmed | Clinical spectrum of elderly-onset inflammatory bowel disease in India |
| title_short | Clinical spectrum of elderly-onset inflammatory bowel disease in India |
| title_sort | clinical spectrum of elderly onset inflammatory bowel disease in india |
| topic | crohn disease colitis, ulcerative inflammatory bowel diseases elderly aged |
| url | http://irjournal.org/upload/pdf/ir-2021-00177.pdf |
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