Paradoxical Effects of Prolonged Insufficient Sleep on Lipid Profile: A Pooled Analysis of 2 Randomized Trials
Background Insufficient sleep is associated with increased cardiovascular disease risk, but causality is unclear. We investigated the impact of prolonged mild sleep restriction (SR) on lipid and inflammatory profiles. Methods and Results Seventy‐eight participants (56 women [12 postmenopausal]; age,...
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| Format: | Article |
| Language: | English |
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Wiley
2023-10-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
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| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.123.032078 |
| _version_ | 1797301641732423680 |
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| author | Rocío Barragán Faris M. Zuraikat Bin Cheng Samantha E. Scaccia Justin Cochran Brooke Aggarwal Sanja Jelic Marie‐Pierre St‐Onge |
| author_facet | Rocío Barragán Faris M. Zuraikat Bin Cheng Samantha E. Scaccia Justin Cochran Brooke Aggarwal Sanja Jelic Marie‐Pierre St‐Onge |
| author_sort | Rocío Barragán |
| collection | DOAJ |
| description | Background Insufficient sleep is associated with increased cardiovascular disease risk, but causality is unclear. We investigated the impact of prolonged mild sleep restriction (SR) on lipid and inflammatory profiles. Methods and Results Seventy‐eight participants (56 women [12 postmenopausal]; age, 34.3±12.5 years; body mass index, 25.8±3.5 kg/m2) with habitual sleep duration 7 to 9 h/night (adequate sleep [AS]) underwent two 6‐week conditions in a randomized crossover design: AS versus SR (AS–1.5 h/night). Total cholesterol, low‐density lipoprotein cholesterol (LDL‐C), high‐density lipoprotein cholesterol, triglycerides, and inflammatory markers (CRP [C‐reactive protein], interleukin 6, and tumor necrosis factor‐α) were assessed. Linear models tested effects of SR on outcomes in the full sample and by sex+menopausal status (premenopausal versus postmenopausal women+men). In the full sample, SR increased high‐density lipoprotein cholesterol compared with AS (β=1.2±0.5 mg/dL; P=0.03). Sex+menopausal status influenced the effects of SR on change in total cholesterol (P‐interaction=0.04), LDL‐C (P‐interaction=0.03), and interleukin 6 (P‐interaction=0.07). Total cholesterol and LDL‐C decreased in SR versus AS in premenopausal women (total cholesterol: β=−4.2±1.9 mg/dL; P=0.03; LDL‐C: β=−6.3±2.0 mg/dL; P=0.002). Given paradoxical effects of SR on cholesterol concentrations, we explored associations between changes in inflammation and end point lipids under each condition. Increases in interleukin 6 and tumor necrosis factor‐α during SR tended to relate to lower LDL‐C in premenopausal women (interleukin 6: β=−5.3±2.6 mg/dL; P=0.051; tumor necrosis factor‐α: β=−32.8±14.2 mg/dL; P=0.027). Conclusions Among healthy adults, prolonged insufficient sleep does not increase atherogenic lipids. However, increased inflammation in SR tends to predict lower LDL‐C in premenopausal women, resembling the “lipid paradox” in which low cholesterol associates with increased cardiovascular disease risk in proinflammatory conditions. Registration URL: https://www.clinicaltrials.gov; Unique identifiers: NCT02835261, NCT02960776. |
| first_indexed | 2024-03-07T23:25:28Z |
| format | Article |
| id | doaj.art-27ea22ba577b4f84958f44233048edb7 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-03-07T23:25:28Z |
| publishDate | 2023-10-01 |
| publisher | Wiley |
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| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-27ea22ba577b4f84958f44233048edb72024-02-21T04:31:11ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802023-10-01122010.1161/JAHA.123.032078Paradoxical Effects of Prolonged Insufficient Sleep on Lipid Profile: A Pooled Analysis of 2 Randomized TrialsRocío Barragán0Faris M. Zuraikat1Bin Cheng2Samantha E. Scaccia3Justin Cochran4Brooke Aggarwal5Sanja Jelic6Marie‐Pierre St‐Onge7Department of Preventive Medicine and Public Health University of Valencia Valencia SpainDepartment of Medicine, Center of Excellence for Sleep and Circadian Research Columbia University Irving Medical Center New York NYDepartment of Biostatistics, Mailman School of Public Health Columbia University Irving Medical Center New York NYDivision of Cardiology, Department of Medicine Columbia University Irving Medical Center New York NYDepartment of Surgery Columbia University Irving Medical Center New York NYDepartment of Medicine, Center of Excellence for Sleep and Circadian Research Columbia University Irving Medical Center New York NYDepartment of Medicine, Center of Excellence for Sleep and Circadian Research Columbia University Irving Medical Center New York NYDepartment of Medicine, Center of Excellence for Sleep and Circadian Research Columbia University Irving Medical Center New York NYBackground Insufficient sleep is associated with increased cardiovascular disease risk, but causality is unclear. We investigated the impact of prolonged mild sleep restriction (SR) on lipid and inflammatory profiles. Methods and Results Seventy‐eight participants (56 women [12 postmenopausal]; age, 34.3±12.5 years; body mass index, 25.8±3.5 kg/m2) with habitual sleep duration 7 to 9 h/night (adequate sleep [AS]) underwent two 6‐week conditions in a randomized crossover design: AS versus SR (AS–1.5 h/night). Total cholesterol, low‐density lipoprotein cholesterol (LDL‐C), high‐density lipoprotein cholesterol, triglycerides, and inflammatory markers (CRP [C‐reactive protein], interleukin 6, and tumor necrosis factor‐α) were assessed. Linear models tested effects of SR on outcomes in the full sample and by sex+menopausal status (premenopausal versus postmenopausal women+men). In the full sample, SR increased high‐density lipoprotein cholesterol compared with AS (β=1.2±0.5 mg/dL; P=0.03). Sex+menopausal status influenced the effects of SR on change in total cholesterol (P‐interaction=0.04), LDL‐C (P‐interaction=0.03), and interleukin 6 (P‐interaction=0.07). Total cholesterol and LDL‐C decreased in SR versus AS in premenopausal women (total cholesterol: β=−4.2±1.9 mg/dL; P=0.03; LDL‐C: β=−6.3±2.0 mg/dL; P=0.002). Given paradoxical effects of SR on cholesterol concentrations, we explored associations between changes in inflammation and end point lipids under each condition. Increases in interleukin 6 and tumor necrosis factor‐α during SR tended to relate to lower LDL‐C in premenopausal women (interleukin 6: β=−5.3±2.6 mg/dL; P=0.051; tumor necrosis factor‐α: β=−32.8±14.2 mg/dL; P=0.027). Conclusions Among healthy adults, prolonged insufficient sleep does not increase atherogenic lipids. However, increased inflammation in SR tends to predict lower LDL‐C in premenopausal women, resembling the “lipid paradox” in which low cholesterol associates with increased cardiovascular disease risk in proinflammatory conditions. Registration URL: https://www.clinicaltrials.gov; Unique identifiers: NCT02835261, NCT02960776.https://www.ahajournals.org/doi/10.1161/JAHA.123.032078clinical trialinflammationinsufficient sleeplipid profilesleep |
| spellingShingle | Rocío Barragán Faris M. Zuraikat Bin Cheng Samantha E. Scaccia Justin Cochran Brooke Aggarwal Sanja Jelic Marie‐Pierre St‐Onge Paradoxical Effects of Prolonged Insufficient Sleep on Lipid Profile: A Pooled Analysis of 2 Randomized Trials Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease clinical trial inflammation insufficient sleep lipid profile sleep |
| title | Paradoxical Effects of Prolonged Insufficient Sleep on Lipid Profile: A Pooled Analysis of 2 Randomized Trials |
| title_full | Paradoxical Effects of Prolonged Insufficient Sleep on Lipid Profile: A Pooled Analysis of 2 Randomized Trials |
| title_fullStr | Paradoxical Effects of Prolonged Insufficient Sleep on Lipid Profile: A Pooled Analysis of 2 Randomized Trials |
| title_full_unstemmed | Paradoxical Effects of Prolonged Insufficient Sleep on Lipid Profile: A Pooled Analysis of 2 Randomized Trials |
| title_short | Paradoxical Effects of Prolonged Insufficient Sleep on Lipid Profile: A Pooled Analysis of 2 Randomized Trials |
| title_sort | paradoxical effects of prolonged insufficient sleep on lipid profile a pooled analysis of 2 randomized trials |
| topic | clinical trial inflammation insufficient sleep lipid profile sleep |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.123.032078 |
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