Brain-Derived Neurotrophic Factor (BDNF) and Translocator Protein (TSPO) as Diagnostic Biomarkers for Acute Ischemic Stroke
Brain-derived neurotrophic factor (BDNF) interacts with tropomyosin-related kinase B (TrkB) to promote neuronal growth, survival, differentiation, neurotransmitter release, and synaptic plasticity. The translocator protein (TSPO) is known to be found in arterial plaques, which are a symptom of ather...
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MDPI AG
2023-07-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/13/2298 |
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| author | Mayuri N. Tuwar Wei-Hung Chen Arthur M. Chiwaya Hsu-Ling Yeh Minh H. Nguyen Chyi-Huey Bai |
| author_facet | Mayuri N. Tuwar Wei-Hung Chen Arthur M. Chiwaya Hsu-Ling Yeh Minh H. Nguyen Chyi-Huey Bai |
| author_sort | Mayuri N. Tuwar |
| collection | DOAJ |
| description | Brain-derived neurotrophic factor (BDNF) interacts with tropomyosin-related kinase B (TrkB) to promote neuronal growth, survival, differentiation, neurotransmitter release, and synaptic plasticity. The translocator protein (TSPO) is known to be found in arterial plaques, which are a symptom of atherosclerosis and a contributory cause of ischemic stroke. This study aims to determine the diagnostic accuracy of plasma BDNF and TSPO levels in discriminating new-onset acute ischemic stroke (AIS) patients from individuals without acute ischemic stroke. A total of 90 AIS patients (61% male, with a mean age of 67.7 ± 12.88) were recruited consecutively in a stroke unit, and each patient was paired with two age- and gender-matched controls. The sensitivity, specificity, and area of the curve between high plasma BDNF and TSPO and having AIS was determined using receiver operating characteristic curves. Furthermore, compared to the controls, AIS patients exhibited significantly higher levels of BDNF and TSPO, blood pressure, HbA1c, and white blood cells, as well as higher creatinine levels. The plasma levels of BDNF and TSPO can significantly discriminate AIS patients from healthy individuals (AUC 0.76 and 0.89, respectively). However, combining the two biomarkers provided little improvement in AUC (0.90). It may be possible to use elevated levels of TSPO as a diagnostic biomarker in patients with acute ischemic stroke upon admission. |
| first_indexed | 2024-03-11T01:43:45Z |
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| id | doaj.art-27eafe1b1a0a496fb8ea6e69d6595168 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T01:43:45Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-27eafe1b1a0a496fb8ea6e69d65951682023-11-18T16:22:47ZengMDPI AGDiagnostics2075-44182023-07-011313229810.3390/diagnostics13132298Brain-Derived Neurotrophic Factor (BDNF) and Translocator Protein (TSPO) as Diagnostic Biomarkers for Acute Ischemic StrokeMayuri N. Tuwar0Wei-Hung Chen1Arthur M. Chiwaya2Hsu-Ling Yeh3Minh H. Nguyen4Chyi-Huey Bai5School of Public Health, College of Public Health, Taipei Medical University, Taipei 106236, TaiwanDepartment of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 111045, TaiwanCLIME Group, Department of Biomedical Sciences, Division of Molecular Biology and Human Genetics, FMHS, Stellenbosch University, Francie Van Zijl Drive, Tygerberg, Cape Town 7505, South AfricaDepartment of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 111045, TaiwanSchool of Preventive Medicine and Public Health, Hanoi Medical University, Hanoi 100000, VietnamSchool of Public Health, College of Public Health, Taipei Medical University, Taipei 106236, TaiwanBrain-derived neurotrophic factor (BDNF) interacts with tropomyosin-related kinase B (TrkB) to promote neuronal growth, survival, differentiation, neurotransmitter release, and synaptic plasticity. The translocator protein (TSPO) is known to be found in arterial plaques, which are a symptom of atherosclerosis and a contributory cause of ischemic stroke. This study aims to determine the diagnostic accuracy of plasma BDNF and TSPO levels in discriminating new-onset acute ischemic stroke (AIS) patients from individuals without acute ischemic stroke. A total of 90 AIS patients (61% male, with a mean age of 67.7 ± 12.88) were recruited consecutively in a stroke unit, and each patient was paired with two age- and gender-matched controls. The sensitivity, specificity, and area of the curve between high plasma BDNF and TSPO and having AIS was determined using receiver operating characteristic curves. Furthermore, compared to the controls, AIS patients exhibited significantly higher levels of BDNF and TSPO, blood pressure, HbA1c, and white blood cells, as well as higher creatinine levels. The plasma levels of BDNF and TSPO can significantly discriminate AIS patients from healthy individuals (AUC 0.76 and 0.89, respectively). However, combining the two biomarkers provided little improvement in AUC (0.90). It may be possible to use elevated levels of TSPO as a diagnostic biomarker in patients with acute ischemic stroke upon admission.https://www.mdpi.com/2075-4418/13/13/2298acute ischemic strokebrain-derived neurotrophic factor (BDNF)translocator protein (TSPO) |
| spellingShingle | Mayuri N. Tuwar Wei-Hung Chen Arthur M. Chiwaya Hsu-Ling Yeh Minh H. Nguyen Chyi-Huey Bai Brain-Derived Neurotrophic Factor (BDNF) and Translocator Protein (TSPO) as Diagnostic Biomarkers for Acute Ischemic Stroke Diagnostics acute ischemic stroke brain-derived neurotrophic factor (BDNF) translocator protein (TSPO) |
| title | Brain-Derived Neurotrophic Factor (BDNF) and Translocator Protein (TSPO) as Diagnostic Biomarkers for Acute Ischemic Stroke |
| title_full | Brain-Derived Neurotrophic Factor (BDNF) and Translocator Protein (TSPO) as Diagnostic Biomarkers for Acute Ischemic Stroke |
| title_fullStr | Brain-Derived Neurotrophic Factor (BDNF) and Translocator Protein (TSPO) as Diagnostic Biomarkers for Acute Ischemic Stroke |
| title_full_unstemmed | Brain-Derived Neurotrophic Factor (BDNF) and Translocator Protein (TSPO) as Diagnostic Biomarkers for Acute Ischemic Stroke |
| title_short | Brain-Derived Neurotrophic Factor (BDNF) and Translocator Protein (TSPO) as Diagnostic Biomarkers for Acute Ischemic Stroke |
| title_sort | brain derived neurotrophic factor bdnf and translocator protein tspo as diagnostic biomarkers for acute ischemic stroke |
| topic | acute ischemic stroke brain-derived neurotrophic factor (BDNF) translocator protein (TSPO) |
| url | https://www.mdpi.com/2075-4418/13/13/2298 |
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