Non-invasive assessment of normal and impaired iron homeostasis in the brain
Abstract Strict iron regulation is essential for normal brain function. The iron homeostasis, determined by the milieu of available iron compounds, is impaired in aging, neurodegenerative diseases and cancer. However, non-invasive assessment of different molecular iron environments implicating brain...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-40999-z |
| _version_ | 1797558060355420160 |
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| author | Shir Filo Rona Shaharabani Daniel Bar Hanin Miriam Adam Eliel Ben-David Hanan Schoffman Nevo Margalit Naomi Habib Tal Shahar Aviv A. Mezer |
| author_facet | Shir Filo Rona Shaharabani Daniel Bar Hanin Miriam Adam Eliel Ben-David Hanan Schoffman Nevo Margalit Naomi Habib Tal Shahar Aviv A. Mezer |
| author_sort | Shir Filo |
| collection | DOAJ |
| description | Abstract Strict iron regulation is essential for normal brain function. The iron homeostasis, determined by the milieu of available iron compounds, is impaired in aging, neurodegenerative diseases and cancer. However, non-invasive assessment of different molecular iron environments implicating brain tissue’s iron homeostasis remains a challenge. We present a magnetic resonance imaging (MRI) technology sensitive to the iron homeostasis of the living brain (the r1-r2 * relaxivity). In vitro, our MRI approach reveals the distinct paramagnetic properties of ferritin, transferrin and ferrous iron ions. In the in vivo human brain, we validate our approach against ex vivo iron compounds quantification and gene expression. Our approach varies with the iron mobilization capacity across brain regions and in aging. It reveals brain tumors’ iron homeostasis, and enhances the distinction between tumor tissue and non-pathological tissue without contrast agents. Therefore, our approach may allow for non-invasive research and diagnosis of iron homeostasis in living human brains. |
| first_indexed | 2024-03-10T17:26:01Z |
| format | Article |
| id | doaj.art-27ecc6c3244c445baedf9d34cc86d75e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-10T17:26:01Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-27ecc6c3244c445baedf9d34cc86d75e2023-11-20T10:10:26ZengNature PortfolioNature Communications2041-17232023-09-0114111910.1038/s41467-023-40999-zNon-invasive assessment of normal and impaired iron homeostasis in the brainShir Filo0Rona Shaharabani1Daniel Bar Hanin2Miriam Adam3Eliel Ben-David4Hanan Schoffman5Nevo Margalit6Naomi Habib7Tal Shahar8Aviv A. Mezer9The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of JerusalemThe Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of JerusalemThe Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of JerusalemThe Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of JerusalemThe Department of Radiology, Shaare Zedek Medical Center, Faculty of Medicine, The Hebrew University of JerusalemThe Laboratory of Molecular Neuro-Oncology, Shaare Zedek Medical Center, Faculty of Medicine, The Hebrew University of JerusalemThe Department of Neurosurgery, Shaare Zedek Medical Center, Faculty of Medicine, The Hebrew University of JerusalemThe Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of JerusalemThe Laboratory of Molecular Neuro-Oncology, Shaare Zedek Medical Center, Faculty of Medicine, The Hebrew University of JerusalemThe Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of JerusalemAbstract Strict iron regulation is essential for normal brain function. The iron homeostasis, determined by the milieu of available iron compounds, is impaired in aging, neurodegenerative diseases and cancer. However, non-invasive assessment of different molecular iron environments implicating brain tissue’s iron homeostasis remains a challenge. We present a magnetic resonance imaging (MRI) technology sensitive to the iron homeostasis of the living brain (the r1-r2 * relaxivity). In vitro, our MRI approach reveals the distinct paramagnetic properties of ferritin, transferrin and ferrous iron ions. In the in vivo human brain, we validate our approach against ex vivo iron compounds quantification and gene expression. Our approach varies with the iron mobilization capacity across brain regions and in aging. It reveals brain tumors’ iron homeostasis, and enhances the distinction between tumor tissue and non-pathological tissue without contrast agents. Therefore, our approach may allow for non-invasive research and diagnosis of iron homeostasis in living human brains.https://doi.org/10.1038/s41467-023-40999-z |
| spellingShingle | Shir Filo Rona Shaharabani Daniel Bar Hanin Miriam Adam Eliel Ben-David Hanan Schoffman Nevo Margalit Naomi Habib Tal Shahar Aviv A. Mezer Non-invasive assessment of normal and impaired iron homeostasis in the brain Nature Communications |
| title | Non-invasive assessment of normal and impaired iron homeostasis in the brain |
| title_full | Non-invasive assessment of normal and impaired iron homeostasis in the brain |
| title_fullStr | Non-invasive assessment of normal and impaired iron homeostasis in the brain |
| title_full_unstemmed | Non-invasive assessment of normal and impaired iron homeostasis in the brain |
| title_short | Non-invasive assessment of normal and impaired iron homeostasis in the brain |
| title_sort | non invasive assessment of normal and impaired iron homeostasis in the brain |
| url | https://doi.org/10.1038/s41467-023-40999-z |
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