Pharmacokinetic Imaging Using <sup>99m</sup>Tc-Mebrofenin to Untangle the Pattern of Hepatocyte Transporter Disruptions Induced by Endotoxemia in Rats

Pharmacokinetic Imaging Using <sup>99m</sup>Tc-Mebrofenin to Untangle the Pattern of Hepatocyte Transporter Disruptions Induced by Endotoxemia in Rats

Endotoxemia-induced inflammation may impact the activity of hepatocyte transporters, which control the hepatobiliary elimination of drugs and bile acids. <sup>99m</sup>Tc-mebrofenin is a non-metabolized substrate of transporters expressed at the different poles of hepatocytes. <sup>...

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Bibliographic Details
Main Authors: Solène Marie, Irene Hernández-Lozano, Marc Le Vée, Louise Breuil, Wadad Saba, Maud Goislard, Sébastien Goutal, Charles Truillet, Oliver Langer, Olivier Fardel, Nicolas Tournier
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Pharmaceuticals
Subjects:
ABC-transporter
drug-induced liver injury
hepatotoxicity
organic anion-transporting polypeptide
pharmacokinetics
liver function
Online Access:https://www.mdpi.com/1424-8247/15/4/392

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https://www.mdpi.com/1424-8247/15/4/392

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