Immune reactions as induction factors and correction of the pathology
On clinical models of infectious, somatic, malignant, and other diseases, the ability of immune responses to induce pathological processes due to competition, “pathogenicity”, hypersensitivity, and insufficiency has been shown. We are talking about the competitiveness of antibacterial and antiviral...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Remedium Group LLC
2022-04-01
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| Series: | Медицинский совет |
| Subjects: | |
| Online Access: | https://www.med-sovet.pro/jour/article/view/6827 |
| _version_ | 1797841483360894976 |
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| author | V. M. Zemskov A. M. Zemskov V. Neymann A. A. Barsukov M. N. Kozlova V. A. Zemskova N. S. Shishkina V. S. Demidova A. A. Alekseev |
| author_facet | V. M. Zemskov A. M. Zemskov V. Neymann A. A. Barsukov M. N. Kozlova V. A. Zemskova N. S. Shishkina V. S. Demidova A. A. Alekseev |
| author_sort | V. M. Zemskov |
| collection | DOAJ |
| description | On clinical models of infectious, somatic, malignant, and other diseases, the ability of immune responses to induce pathological processes due to competition, “pathogenicity”, hypersensitivity, and insufficiency has been shown. We are talking about the competitiveness of antibacterial and antiviral immunity, when the deployment of cellular and humoral immune responses weaken both defense mechanisms, competition of allergy and immune deficiency, which aggravates and modifies it, and antiviral immunity often induces a number of pathological conditions of the body. This is due to the inability of antiviral antibodies to completely inactivate the antireceptor structures of virions, interact with them without changing their function, and even stimulate a viral infection, induce autoimmune reactions. The protective system of interferons, which often cause side reactions, is also faulty. In the body, immunopathological reactions develop, manifested by immediate and delayed hypersensitivity, which have alternative properties – protective and damaging and autoimmune reactions, mainly with a negative effect. The mechanisms of the processes are discussed in detail in the review. The “inferiority” of immune reactions, respectively, cellular, humoral, phagocytic links, incomplete consistency of anticancer immunity, virus-induced immunodeficiencies are comprehensively covered. Such “alternativeness” of the considered immune reactions, at the same time, turns out to be a necessary condition for eliminating the emerging disorders of the organism’s reactivity. These include specificity and non-specificity, stimulation and suppression, variability and integration of immune responses. At the same time, immunoregulatory reactions are individual and interrelated, develop regionally and systemically and provide degradation of exogenous and endogenous objects and immune activation. All these aspects are discussed in detail in the review. |
| first_indexed | 2024-04-09T16:31:36Z |
| format | Article |
| id | doaj.art-27efd655d4204114af5ef54044fd46e0 |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:31:36Z |
| publishDate | 2022-04-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-27efd655d4204114af5ef54044fd46e02023-04-23T06:57:04ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902022-04-010616617410.21518/2079-701X-2022-16-6-166-1746132Immune reactions as induction factors and correction of the pathologyV. M. Zemskov0A. M. Zemskov1V. Neymann2A. A. Barsukov3M. N. Kozlova4V. A. Zemskova5N. S. Shishkina6V. S. Demidova7A. A. Alekseev8Vishnevsky National Medical Research Center of SurgeryBurdenko Voronezh State Medical UniversityVRFD SAVishnevsky National Medical Research Center of SurgeryVishnevsky National Medical Research Center of SurgeryBurdenko Voronezh State Medical UniversityVishnevsky National Medical Research Center of SurgeryVishnevsky National Medical Research Center of SurgeryVishnevsky National Medical Research Center of SurgeryOn clinical models of infectious, somatic, malignant, and other diseases, the ability of immune responses to induce pathological processes due to competition, “pathogenicity”, hypersensitivity, and insufficiency has been shown. We are talking about the competitiveness of antibacterial and antiviral immunity, when the deployment of cellular and humoral immune responses weaken both defense mechanisms, competition of allergy and immune deficiency, which aggravates and modifies it, and antiviral immunity often induces a number of pathological conditions of the body. This is due to the inability of antiviral antibodies to completely inactivate the antireceptor structures of virions, interact with them without changing their function, and even stimulate a viral infection, induce autoimmune reactions. The protective system of interferons, which often cause side reactions, is also faulty. In the body, immunopathological reactions develop, manifested by immediate and delayed hypersensitivity, which have alternative properties – protective and damaging and autoimmune reactions, mainly with a negative effect. The mechanisms of the processes are discussed in detail in the review. The “inferiority” of immune reactions, respectively, cellular, humoral, phagocytic links, incomplete consistency of anticancer immunity, virus-induced immunodeficiencies are comprehensively covered. Such “alternativeness” of the considered immune reactions, at the same time, turns out to be a necessary condition for eliminating the emerging disorders of the organism’s reactivity. These include specificity and non-specificity, stimulation and suppression, variability and integration of immune responses. At the same time, immunoregulatory reactions are individual and interrelated, develop regionally and systemically and provide degradation of exogenous and endogenous objects and immune activation. All these aspects are discussed in detail in the review.https://www.med-sovet.pro/jour/article/view/6827infectious and somatic diseasesoncologyallergyimmune deficiencyimmunopathology |
| spellingShingle | V. M. Zemskov A. M. Zemskov V. Neymann A. A. Barsukov M. N. Kozlova V. A. Zemskova N. S. Shishkina V. S. Demidova A. A. Alekseev Immune reactions as induction factors and correction of the pathology Медицинский совет infectious and somatic diseases oncology allergy immune deficiency immunopathology |
| title | Immune reactions as induction factors and correction of the pathology |
| title_full | Immune reactions as induction factors and correction of the pathology |
| title_fullStr | Immune reactions as induction factors and correction of the pathology |
| title_full_unstemmed | Immune reactions as induction factors and correction of the pathology |
| title_short | Immune reactions as induction factors and correction of the pathology |
| title_sort | immune reactions as induction factors and correction of the pathology |
| topic | infectious and somatic diseases oncology allergy immune deficiency immunopathology |
| url | https://www.med-sovet.pro/jour/article/view/6827 |
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