The Role of Reprogrammed Glucose Metabolism in Cancer
Cancer cells reprogram their metabolism to meet biosynthetic needs and to adapt to various microenvironments. Accelerated glycolysis offers proliferative benefits for malignant cells by generating glycolytic products that move into branched pathways to synthesize proteins, fatty acids, nucleotides,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Metabolites |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-1989/13/3/345 |
| _version_ | 1797610194147999744 |
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| author | Meran Keshawa Ediriweera Sharmila Jayasena |
| author_facet | Meran Keshawa Ediriweera Sharmila Jayasena |
| author_sort | Meran Keshawa Ediriweera |
| collection | DOAJ |
| description | Cancer cells reprogram their metabolism to meet biosynthetic needs and to adapt to various microenvironments. Accelerated glycolysis offers proliferative benefits for malignant cells by generating glycolytic products that move into branched pathways to synthesize proteins, fatty acids, nucleotides, and lipids. Notably, reprogrammed glucose metabolism and its associated events support the hallmark features of cancer such as sustained cell proliferation, hijacked apoptosis, invasion, metastasis, and angiogenesis. Overproduced enzymes involved in the committed steps of glycolysis (hexokinase, phosphofructokinase-1, and pyruvate kinase) are promising pharmacological targets for cancer therapeutics. In this review, we summarize the role of reprogrammed glucose metabolism in cancer cells and how it can be manipulated for anti-cancer strategies. |
| first_indexed | 2024-03-11T06:11:06Z |
| format | Article |
| id | doaj.art-27f1e6a7b68c48b1b67857956b037570 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-11T06:11:06Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-27f1e6a7b68c48b1b67857956b0375702023-11-17T12:36:11ZengMDPI AGMetabolites2218-19892023-02-0113334510.3390/metabo13030345The Role of Reprogrammed Glucose Metabolism in CancerMeran Keshawa Ediriweera0Sharmila Jayasena1Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Colombo, Colombo 08, Sri LankaDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, University of Colombo, Colombo 08, Sri LankaCancer cells reprogram their metabolism to meet biosynthetic needs and to adapt to various microenvironments. Accelerated glycolysis offers proliferative benefits for malignant cells by generating glycolytic products that move into branched pathways to synthesize proteins, fatty acids, nucleotides, and lipids. Notably, reprogrammed glucose metabolism and its associated events support the hallmark features of cancer such as sustained cell proliferation, hijacked apoptosis, invasion, metastasis, and angiogenesis. Overproduced enzymes involved in the committed steps of glycolysis (hexokinase, phosphofructokinase-1, and pyruvate kinase) are promising pharmacological targets for cancer therapeutics. In this review, we summarize the role of reprogrammed glucose metabolism in cancer cells and how it can be manipulated for anti-cancer strategies.https://www.mdpi.com/2218-1989/13/3/345glucosecancercancer treatmentmetabolism |
| spellingShingle | Meran Keshawa Ediriweera Sharmila Jayasena The Role of Reprogrammed Glucose Metabolism in Cancer Metabolites glucose cancer cancer treatment metabolism |
| title | The Role of Reprogrammed Glucose Metabolism in Cancer |
| title_full | The Role of Reprogrammed Glucose Metabolism in Cancer |
| title_fullStr | The Role of Reprogrammed Glucose Metabolism in Cancer |
| title_full_unstemmed | The Role of Reprogrammed Glucose Metabolism in Cancer |
| title_short | The Role of Reprogrammed Glucose Metabolism in Cancer |
| title_sort | role of reprogrammed glucose metabolism in cancer |
| topic | glucose cancer cancer treatment metabolism |
| url | https://www.mdpi.com/2218-1989/13/3/345 |
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