Vincristine induced peripheral neuropathy in children undergoing chemotherapy for acute lymphoblastic leukaemia during induction
Background: Vincristine is an anticancer agent administered to all children with acute lymphoblastic leukemia (ALL), and peripheral neuropathy is the major dose-limiting toxicity of this therapy. As cure rates of childhood ALL exceeds 80%, therefore treatment-related toxicities need to be reduced....
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Bangabandhu Sheikh Mujib Medical University
2023-04-01
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| Series: | Bangabandhu Sheikh Mujib Medical University Journal |
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| Online Access: | https://banglajol.info/index.php/BSMMUJ/article/view/65657 |
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| author | Nazneen Sultana Chowdhury Yakub Jamal ATM Atikur Rahman Shahinoor Akter Soma Md Nazrul Islam Mondal Abu Haider Md Raziul Mazid |
| author_facet | Nazneen Sultana Chowdhury Yakub Jamal ATM Atikur Rahman Shahinoor Akter Soma Md Nazrul Islam Mondal Abu Haider Md Raziul Mazid |
| author_sort | Nazneen Sultana |
| collection | DOAJ |
| description |
Background: Vincristine is an anticancer agent administered to all children with acute lymphoblastic leukemia (ALL), and peripheral neuropathy is the major dose-limiting toxicity of this therapy. As cure rates of childhood ALL exceeds 80%, therefore treatment-related toxicities need to be reduced. Thus, the aim of this study was to determine the prevalence and risk factors of vincristine-induced peripheral neuropathy (VIPN) in children with ALL undergoing induction chemotherapy.
Methods: A case-control study was conducted from September 2017 to August 2018 in the Department of Paediatric Haematology and Oncology at Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. Eighty newly diagnosed ALL and 35 acute myeloid leukemia (AML) cases aged 5 to 17 years with no pre-existing neurological abnormality were recruited. To assess the peripheral neuropathy, we used pediatric-modified total neuropathy score and National Cancer Institute- Common Terminology Criteria for Adverse Events (NCI-CTCAE), version-04 grade.
Results: Among ALL patients, 29.2% developed peripheral neuropathy compared to 10% in AML control group (P=0.04). Higher proportion (57.1%) of peripheral neuropathy was found in age below 10 years (P<0.001). There was no significant association of peripheral neuropathy with sex and body mass index of the patients.
Conclusion: Almost 3 in 10 patients developed VIPN during the induction therapy which is significantly higher in age below 10 years compared to ≥ 10 years.
Bangabandhu Sheikh Mujib Medical University Journal 2023;16(1): 02-07
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| first_indexed | 2024-04-09T17:27:55Z |
| format | Article |
| id | doaj.art-27f2863ce08048b38361dfdfb6d1e4f0 |
| institution | Directory Open Access Journal |
| issn | 2074-2908 2224-7750 |
| language | English |
| last_indexed | 2024-04-09T17:27:55Z |
| publishDate | 2023-04-01 |
| publisher | Bangabandhu Sheikh Mujib Medical University |
| record_format | Article |
| series | Bangabandhu Sheikh Mujib Medical University Journal |
| spelling | doaj.art-27f2863ce08048b38361dfdfb6d1e4f02023-04-18T10:01:02ZengBangabandhu Sheikh Mujib Medical UniversityBangabandhu Sheikh Mujib Medical University Journal2074-29082224-77502023-04-01161Vincristine induced peripheral neuropathy in children undergoing chemotherapy for acute lymphoblastic leukaemia during inductionNazneen Sultana0Chowdhury Yakub Jamal1ATM Atikur Rahman2Shahinoor Akter Soma3Md Nazrul Islam Mondal4Abu Haider Md Raziul Mazid5Nazneen Sultana, MD ( Pediatric hematology and Oncology), Medical Officer, Muradnagar Upazila Health Complex, Muradnagar, CumillaProfessor, Department of Pediatric Hematology and Oncology, Department of Pediatric Hematology and Oncology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.Professor, Department of Pediatric Hematology and Oncology, Department of Pediatric Hematology and Oncology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, BangladeshMD, Pediatric Hematology and Oncology, Junior consultant, Upazila Health Complex Nawabganj, Dhaka, Bangladesh.IMO, Department of Pediatric Hematology and Oncology, Rajshahi Medical College Hospital, Rajshahi, Bangladesh. MO, Department of Pediatric Hematology and Oncology, Gaibandha district Hospital, Rangpur, Bangladesh Background: Vincristine is an anticancer agent administered to all children with acute lymphoblastic leukemia (ALL), and peripheral neuropathy is the major dose-limiting toxicity of this therapy. As cure rates of childhood ALL exceeds 80%, therefore treatment-related toxicities need to be reduced. Thus, the aim of this study was to determine the prevalence and risk factors of vincristine-induced peripheral neuropathy (VIPN) in children with ALL undergoing induction chemotherapy. Methods: A case-control study was conducted from September 2017 to August 2018 in the Department of Paediatric Haematology and Oncology at Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. Eighty newly diagnosed ALL and 35 acute myeloid leukemia (AML) cases aged 5 to 17 years with no pre-existing neurological abnormality were recruited. To assess the peripheral neuropathy, we used pediatric-modified total neuropathy score and National Cancer Institute- Common Terminology Criteria for Adverse Events (NCI-CTCAE), version-04 grade. Results: Among ALL patients, 29.2% developed peripheral neuropathy compared to 10% in AML control group (P=0.04). Higher proportion (57.1%) of peripheral neuropathy was found in age below 10 years (P<0.001). There was no significant association of peripheral neuropathy with sex and body mass index of the patients. Conclusion: Almost 3 in 10 patients developed VIPN during the induction therapy which is significantly higher in age below 10 years compared to ≥ 10 years. Bangabandhu Sheikh Mujib Medical University Journal 2023;16(1): 02-07 https://banglajol.info/index.php/BSMMUJ/article/view/65657peripheral neuropathy, risk factors, acute lymphoblastic leukemia, induction remission chemotherapy, pediatric-modified total neuropathy score |
| spellingShingle | Nazneen Sultana Chowdhury Yakub Jamal ATM Atikur Rahman Shahinoor Akter Soma Md Nazrul Islam Mondal Abu Haider Md Raziul Mazid Vincristine induced peripheral neuropathy in children undergoing chemotherapy for acute lymphoblastic leukaemia during induction Bangabandhu Sheikh Mujib Medical University Journal peripheral neuropathy, risk factors, acute lymphoblastic leukemia, induction remission chemotherapy, pediatric-modified total neuropathy score |
| title | Vincristine induced peripheral neuropathy in children undergoing chemotherapy for acute lymphoblastic leukaemia during induction |
| title_full | Vincristine induced peripheral neuropathy in children undergoing chemotherapy for acute lymphoblastic leukaemia during induction |
| title_fullStr | Vincristine induced peripheral neuropathy in children undergoing chemotherapy for acute lymphoblastic leukaemia during induction |
| title_full_unstemmed | Vincristine induced peripheral neuropathy in children undergoing chemotherapy for acute lymphoblastic leukaemia during induction |
| title_short | Vincristine induced peripheral neuropathy in children undergoing chemotherapy for acute lymphoblastic leukaemia during induction |
| title_sort | vincristine induced peripheral neuropathy in children undergoing chemotherapy for acute lymphoblastic leukaemia during induction |
| topic | peripheral neuropathy, risk factors, acute lymphoblastic leukemia, induction remission chemotherapy, pediatric-modified total neuropathy score |
| url | https://banglajol.info/index.php/BSMMUJ/article/view/65657 |
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