<b>Cd, Cu, and Mn from Uruguay River Basin in Uruguaiana, RS, Brazil, and their toxicological potential for human leukocyte
This study assessed the limnology from the Medium Uruguay River Basin in Uruguaiana, Brazil, with a focus on the concentration of heavy metals (Cd, Cu, and Mn), to assess the toxicological potential (cytotoxicity and genotoxicity) for humans using as biological matrix of study human leukocyte cells....
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| Format: | Article |
| Language: | English |
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Universidade Estadual de Maringá
2016-12-01
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| Series: | Acta Scientiarum: Biological Sciences |
| Subjects: | |
| Online Access: | https://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/31998 |
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| author | Gislaine Rezer Costa Mariana Balhego Rocha Marcus Vinicius Morini Querol Jacir Dal Magro Michel Mansur Machado Luís Flávio Souza de Oliveira |
| author_facet | Gislaine Rezer Costa Mariana Balhego Rocha Marcus Vinicius Morini Querol Jacir Dal Magro Michel Mansur Machado Luís Flávio Souza de Oliveira |
| author_sort | Gislaine Rezer Costa |
| collection | DOAJ |
| description | This study assessed the limnology from the Medium Uruguay River Basin in Uruguaiana, Brazil, with a focus on the concentration of heavy metals (Cd, Cu, and Mn), to assess the toxicological potential (cytotoxicity and genotoxicity) for humans using as biological matrix of study human leukocyte cells. The conductivity, resistivity, and dissolved O2 levels exceeded the limits recommended by the National Environmental Council (Conselho Nacional do Meio Ambiente - CONAMA). The percentage of non-viable human leukocyte cells exposed to water samples was approximately 20% higher than that of the negative control (<3%), but similar to the positive control. The DNA damage index was high for all heavy metal concentrations assayed when compared to the negative control 12±2.96, p < 0.0001, with a range of 155.66±23.89 to 194.33±23.23, but similar to the positive control (210.62±27.48). Moreover, the leukocyte degeneration index was higher in all samples containing heavy metals than in the negative control (4%), which demonstrates to be due the presence of Cu (11.8-12.5%), Cd (13-15.6%), and Mn (15.6-22.5%). Taken together, our results show that the quality from water samples analyzed is below than recommended by CONAMA and offers risk of contamination by heavy metals for the general population.
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| first_indexed | 2024-04-12T10:27:52Z |
| format | Article |
| id | doaj.art-27f36bdfa81c4d45b92d2877b6e053f7 |
| institution | Directory Open Access Journal |
| issn | 1679-9283 1807-863X |
| language | English |
| last_indexed | 2024-04-12T10:27:52Z |
| publishDate | 2016-12-01 |
| publisher | Universidade Estadual de Maringá |
| record_format | Article |
| series | Acta Scientiarum: Biological Sciences |
| spelling | doaj.art-27f36bdfa81c4d45b92d2877b6e053f72022-12-22T03:36:55ZengUniversidade Estadual de MaringáActa Scientiarum: Biological Sciences1679-92831807-863X2016-12-0138410.4025/actascibiolsci.v38i4.3199814833<b>Cd, Cu, and Mn from Uruguay River Basin in Uruguaiana, RS, Brazil, and their toxicological potential for human leukocyteGislaine Rezer Costa0Mariana Balhego Rocha1Marcus Vinicius Morini Querol2Jacir Dal Magro3Michel Mansur Machado4Luís Flávio Souza de Oliveira5Universidade Federal do PampaUniversidade Federal do PampaUniversidade Federal do PampaUniversidade Comunitária da Região de ChapecóUniversidade Federal do PampaUniversidade Federal do PampaThis study assessed the limnology from the Medium Uruguay River Basin in Uruguaiana, Brazil, with a focus on the concentration of heavy metals (Cd, Cu, and Mn), to assess the toxicological potential (cytotoxicity and genotoxicity) for humans using as biological matrix of study human leukocyte cells. The conductivity, resistivity, and dissolved O2 levels exceeded the limits recommended by the National Environmental Council (Conselho Nacional do Meio Ambiente - CONAMA). The percentage of non-viable human leukocyte cells exposed to water samples was approximately 20% higher than that of the negative control (<3%), but similar to the positive control. The DNA damage index was high for all heavy metal concentrations assayed when compared to the negative control 12±2.96, p < 0.0001, with a range of 155.66±23.89 to 194.33±23.23, but similar to the positive control (210.62±27.48). Moreover, the leukocyte degeneration index was higher in all samples containing heavy metals than in the negative control (4%), which demonstrates to be due the presence of Cu (11.8-12.5%), Cd (13-15.6%), and Mn (15.6-22.5%). Taken together, our results show that the quality from water samples analyzed is below than recommended by CONAMA and offers risk of contamination by heavy metals for the general population. https://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/31998ecotoxicologygenotoxicitylimnologyheavy metalsUruguay River Basin |
| spellingShingle | Gislaine Rezer Costa Mariana Balhego Rocha Marcus Vinicius Morini Querol Jacir Dal Magro Michel Mansur Machado Luís Flávio Souza de Oliveira <b>Cd, Cu, and Mn from Uruguay River Basin in Uruguaiana, RS, Brazil, and their toxicological potential for human leukocyte Acta Scientiarum: Biological Sciences ecotoxicology genotoxicity limnology heavy metals Uruguay River Basin |
| title | <b>Cd, Cu, and Mn from Uruguay River Basin in Uruguaiana, RS, Brazil, and their toxicological potential for human leukocyte |
| title_full | <b>Cd, Cu, and Mn from Uruguay River Basin in Uruguaiana, RS, Brazil, and their toxicological potential for human leukocyte |
| title_fullStr | <b>Cd, Cu, and Mn from Uruguay River Basin in Uruguaiana, RS, Brazil, and their toxicological potential for human leukocyte |
| title_full_unstemmed | <b>Cd, Cu, and Mn from Uruguay River Basin in Uruguaiana, RS, Brazil, and their toxicological potential for human leukocyte |
| title_short | <b>Cd, Cu, and Mn from Uruguay River Basin in Uruguaiana, RS, Brazil, and their toxicological potential for human leukocyte |
| title_sort | b cd cu and mn from uruguay river basin in uruguaiana rs brazil and their toxicological potential for human leukocyte |
| topic | ecotoxicology genotoxicity limnology heavy metals Uruguay River Basin |
| url | https://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/31998 |
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