B-Cell Epitope Mapping of TprC and TprD Variants of Treponema pallidum Subspecies Informs Vaccine Development for Human Treponematoses

B-Cell Epitope Mapping of TprC and TprD Variants of Treponema pallidum Subspecies Informs Vaccine Development for Human Treponematoses

Several recent studies have focused on the identification, functional analysis, and structural characterization of outer membrane proteins (OMPs) of Treponema pallidum (Tp). The Tp species encompasses the highly related pallidum, pertenue, and endemicum subspecies of this pathogen, known to be the c...

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Bibliographic Details
Main Authors: Barbara Molini, Mark C. Fernandez, Charmie Godornes, Anastassia Vorobieva, Sheila A. Lukehart, Lorenzo Giacani
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Immunology
Subjects:
Treponema pallidum
syphilis
Tpr proteins
B-cell epitope mapping
vaccine development
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.862491/full

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