Hepatoprotective effects of Artemia salina L. extract against carbon tetrachloride-induced toxicity
The protective effects of Artemia salina L. extract was examined against carbon tetrachloride (CCl4)-induced cell toxicity. In the in vitro model of study, markers such as cell viability, cellular reduced and oxidized glutathione, and lipid peroxidation in HepG2 cells was evaluated. Human liver canc...
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| Format: | Article |
| Language: | English |
| Published: |
Shiraz University of Medical Sciences
2016-12-01
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| Series: | Trends in Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://tips.sums.ac.ir/article_42207_8b3964f2797112ac4c4f7cb457bf6d54.pdf |
| _version_ | 1818355380596506624 |
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| author | Mohammad Ali Mobasher Akram Jamshidzadeh Reza Heidari Ghazal Ghahiri Nazanin Mobasher |
| author_facet | Mohammad Ali Mobasher Akram Jamshidzadeh Reza Heidari Ghazal Ghahiri Nazanin Mobasher |
| author_sort | Mohammad Ali Mobasher |
| collection | DOAJ |
| description | The protective effects of Artemia salina L. extract was examined against carbon tetrachloride (CCl4)-induced cell toxicity. In the in vitro model of study, markers such as cell viability, cellular reduced and oxidized glutathione, and lipid peroxidation in HepG2 cells was evaluated. Human liver cancer cell line HepG2 was treated with CCl4 and Artemia salina extract, and markers of hepatotoxicity were investigated. Artemia salina extract showed significant dose-dependent protective effects against the cytotoxicity of CCl4. This extract was able to normalize the levels of GSH, and thiobarbituric acid-reactive (TBARs), which were altered due to CCl4 intoxication in HepG2 cells. As the oxidative stress markers were ameliorated, it might be concluded that Artemia salina extract possesses protective effects probably due to its antioxidant constituents. |
| first_indexed | 2024-12-13T19:40:24Z |
| format | Article |
| id | doaj.art-27f47f4897c4478d816d548115a4e67b |
| institution | Directory Open Access Journal |
| issn | 2423-5652 |
| language | English |
| last_indexed | 2024-12-13T19:40:24Z |
| publishDate | 2016-12-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Trends in Pharmaceutical Sciences |
| spelling | doaj.art-27f47f4897c4478d816d548115a4e67b2022-12-21T23:33:42ZengShiraz University of Medical SciencesTrends in Pharmaceutical Sciences2423-56522016-12-012425926442207Hepatoprotective effects of Artemia salina L. extract against carbon tetrachloride-induced toxicityMohammad Ali Mobasher0Akram JamshidzadehReza HeidariGhazal GhahiriNazanin MobasherDepartment of Medical Biotechnology, School of Medicine, Fasa University of Medical Sciences, Fasa, Fars, Iran.The protective effects of Artemia salina L. extract was examined against carbon tetrachloride (CCl4)-induced cell toxicity. In the in vitro model of study, markers such as cell viability, cellular reduced and oxidized glutathione, and lipid peroxidation in HepG2 cells was evaluated. Human liver cancer cell line HepG2 was treated with CCl4 and Artemia salina extract, and markers of hepatotoxicity were investigated. Artemia salina extract showed significant dose-dependent protective effects against the cytotoxicity of CCl4. This extract was able to normalize the levels of GSH, and thiobarbituric acid-reactive (TBARs), which were altered due to CCl4 intoxication in HepG2 cells. As the oxidative stress markers were ameliorated, it might be concluded that Artemia salina extract possesses protective effects probably due to its antioxidant constituents.https://tips.sums.ac.ir/article_42207_8b3964f2797112ac4c4f7cb457bf6d54.pdfhepatotoxicityccl4artemia salina loxidative stresshepg2 cells |
| spellingShingle | Mohammad Ali Mobasher Akram Jamshidzadeh Reza Heidari Ghazal Ghahiri Nazanin Mobasher Hepatoprotective effects of Artemia salina L. extract against carbon tetrachloride-induced toxicity Trends in Pharmaceutical Sciences hepatotoxicity ccl4 artemia salina l oxidative stress hepg2 cells |
| title | Hepatoprotective effects of Artemia salina L. extract against carbon tetrachloride-induced toxicity |
| title_full | Hepatoprotective effects of Artemia salina L. extract against carbon tetrachloride-induced toxicity |
| title_fullStr | Hepatoprotective effects of Artemia salina L. extract against carbon tetrachloride-induced toxicity |
| title_full_unstemmed | Hepatoprotective effects of Artemia salina L. extract against carbon tetrachloride-induced toxicity |
| title_short | Hepatoprotective effects of Artemia salina L. extract against carbon tetrachloride-induced toxicity |
| title_sort | hepatoprotective effects of artemia salina l extract against carbon tetrachloride induced toxicity |
| topic | hepatotoxicity ccl4 artemia salina l oxidative stress hepg2 cells |
| url | https://tips.sums.ac.ir/article_42207_8b3964f2797112ac4c4f7cb457bf6d54.pdf |
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