Berberin sustained-release nanoparticles were enriched in infarcted rat myocardium and resolved inflammation
Abstract Inflammatory regulation induced by macrophage polarization is essential for cardiac repair after myocardial infarction (MI). Berberin (BBR) is an isoquinoline tetrasystemic alkaloid extracted from plants. This study analyzes the most likely mechanism of BBR in MI treatment determined via ne...
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-023-01790-w |
| _version_ | 1811175673695305728 |
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| author | Ke Zhu Yu Yao Kun Wang Fuqiang Shao Ziyang Zhu Yangmeihui Song Zhangyongxue Zhou Dawei Jiang Xiaoli Lan Chunxia Qin |
| author_facet | Ke Zhu Yu Yao Kun Wang Fuqiang Shao Ziyang Zhu Yangmeihui Song Zhangyongxue Zhou Dawei Jiang Xiaoli Lan Chunxia Qin |
| author_sort | Ke Zhu |
| collection | DOAJ |
| description | Abstract Inflammatory regulation induced by macrophage polarization is essential for cardiac repair after myocardial infarction (MI). Berberin (BBR) is an isoquinoline tetrasystemic alkaloid extracted from plants. This study analyzes the most likely mechanism of BBR in MI treatment determined via network pharmacology, showing that BBR acts mainly through inflammatory responses. Because platelets (PLTs) can be enriched in the infarcted myocardium, PLT membrane-coated polylactic-co-glycolic acid (PLGA) nanoparticles (BBR@PLGA@PLT NPs) are used, which show enrichment in the infarcted myocardium to deliver BBR sustainably. Compared with PLGA nanoparticles, BBR@PLGA@PLT NPs are more enriched in the infarcted myocardium and exhibit less uptake in the liver. On day three after MI, BBR@PLGA@PLT NPs administration significantly increases the number of repaired macrophages and decreases the number of inflammatory macrophages and apoptotic cells in infarcted rat myocardium. On the 28th day after MI, the BBR@PLGA@PLT group exhibits a protective effect on cardiac function, reduced cardiac collagen deposition, improved scar tissue stiffness, and an excellent angiogenesis effect. In addition, BBR@PLGA@PLT group has no significant impact on major organs either histologically or enzymologically. In summary, the therapeutic effect of BBR@PLGA@PLT NPs on MI is presented in detail from the perspective of the resolution of inflammation, and a new solution for MI treatment is proposed. Graphical Abstract |
| first_indexed | 2024-04-10T19:40:37Z |
| format | Article |
| id | doaj.art-27f974db1f2d429c98e07026c2c12b19 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-10T19:40:37Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-27f974db1f2d429c98e07026c2c12b192023-01-29T12:21:10ZengBMCJournal of Nanobiotechnology1477-31552023-01-0121111710.1186/s12951-023-01790-wBerberin sustained-release nanoparticles were enriched in infarcted rat myocardium and resolved inflammationKe Zhu0Yu Yao1Kun Wang2Fuqiang Shao3Ziyang Zhu4Yangmeihui Song5Zhangyongxue Zhou6Dawei Jiang7Xiaoli Lan8Chunxia Qin9Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Ultrasound, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Nuclear Medicine, The First People’s Hospital of ZigongDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Inflammatory regulation induced by macrophage polarization is essential for cardiac repair after myocardial infarction (MI). Berberin (BBR) is an isoquinoline tetrasystemic alkaloid extracted from plants. This study analyzes the most likely mechanism of BBR in MI treatment determined via network pharmacology, showing that BBR acts mainly through inflammatory responses. Because platelets (PLTs) can be enriched in the infarcted myocardium, PLT membrane-coated polylactic-co-glycolic acid (PLGA) nanoparticles (BBR@PLGA@PLT NPs) are used, which show enrichment in the infarcted myocardium to deliver BBR sustainably. Compared with PLGA nanoparticles, BBR@PLGA@PLT NPs are more enriched in the infarcted myocardium and exhibit less uptake in the liver. On day three after MI, BBR@PLGA@PLT NPs administration significantly increases the number of repaired macrophages and decreases the number of inflammatory macrophages and apoptotic cells in infarcted rat myocardium. On the 28th day after MI, the BBR@PLGA@PLT group exhibits a protective effect on cardiac function, reduced cardiac collagen deposition, improved scar tissue stiffness, and an excellent angiogenesis effect. In addition, BBR@PLGA@PLT group has no significant impact on major organs either histologically or enzymologically. In summary, the therapeutic effect of BBR@PLGA@PLT NPs on MI is presented in detail from the perspective of the resolution of inflammation, and a new solution for MI treatment is proposed. Graphical Abstracthttps://doi.org/10.1186/s12951-023-01790-wMyocardial infarctionInflammationBerberinNanoparticleTargetedSustained release |
| spellingShingle | Ke Zhu Yu Yao Kun Wang Fuqiang Shao Ziyang Zhu Yangmeihui Song Zhangyongxue Zhou Dawei Jiang Xiaoli Lan Chunxia Qin Berberin sustained-release nanoparticles were enriched in infarcted rat myocardium and resolved inflammation Journal of Nanobiotechnology Myocardial infarction Inflammation Berberin Nanoparticle Targeted Sustained release |
| title | Berberin sustained-release nanoparticles were enriched in infarcted rat myocardium and resolved inflammation |
| title_full | Berberin sustained-release nanoparticles were enriched in infarcted rat myocardium and resolved inflammation |
| title_fullStr | Berberin sustained-release nanoparticles were enriched in infarcted rat myocardium and resolved inflammation |
| title_full_unstemmed | Berberin sustained-release nanoparticles were enriched in infarcted rat myocardium and resolved inflammation |
| title_short | Berberin sustained-release nanoparticles were enriched in infarcted rat myocardium and resolved inflammation |
| title_sort | berberin sustained release nanoparticles were enriched in infarcted rat myocardium and resolved inflammation |
| topic | Myocardial infarction Inflammation Berberin Nanoparticle Targeted Sustained release |
| url | https://doi.org/10.1186/s12951-023-01790-w |
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