Prominently Increased of Mannose Binding Lectin (MBL) and Myeloperoxidase (MPO) Levels in Severe Valve Regurgitation and Heart Failure of Rheumatic Heart Disease
Rheumatic heart disease (RHD) is mediated by an abnormal immunological response following a Streptococcus pyogenes infection that induces a disturbance of oxidants and antioxidants balances. Mannose-binding lectin (MBL) binds to N-acetylglucosamine, a molecule present on the Streptococcus cell wall...
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| Format: | Article |
| Language: | English |
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University of Brawijaya
2017-06-01
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| Series: | Journal of Tropical Life Science |
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| Online Access: | http://jtrolis.ub.ac.id/index.php/jtrolis/article/view/615 |
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| author | Rachmania Putri Renny Suwarniaty Loeki Enggar Fitri Susanto Nugroho Mohammad Saifur Rahman |
| author_facet | Rachmania Putri Renny Suwarniaty Loeki Enggar Fitri Susanto Nugroho Mohammad Saifur Rahman |
| author_sort | Rachmania Putri |
| collection | DOAJ |
| description | Rheumatic heart disease (RHD) is mediated by an abnormal immunological response following a Streptococcus pyogenes infection that induces a disturbance of oxidants and antioxidants balances. Mannose-binding lectin (MBL) binds to N-acetylglucosamine, a molecule present on the Streptococcus cell wall and human heart valves. There is a disturbance of oxidant and antioxidant balance in rheumatic disease. Myeloperoxidase (MPO) is a marker of oxidative stress and inflammation. This study was aimed to determine the correlation of MBL and MPO levels and severity of valvular regurgitation and heart failure (HF) in RHD patients. A case-control study was conduct using human peripheral blood samples from 32 children aged 6 to 14 years old. The subjects were divided into two groups: 16 RHD patients included in the case group and 16 healthy children as a control group. The level of MBL and MPO was investigated using ELISA method. There were significant differences on MBL and MPO level between patient and control group. The level of MBL and MPO were significantly increased in RHD group, especially on severe valvular regurgitation. There was a strong correlation between MBL and MPO levels and the severity of valvular regurgitation (r = 0.94 and r = 0.88). The least significant diff-erence (LSD) analysis showed that significant difference occurs in the severe heart failure group. Our research revealed that the MBL and MPO levels in pediatric RHD patients were significantly higher than in healthy children. The MBL and MPO levels were significantly correlated with the severity of valvular regurgitation and heart failure. |
| first_indexed | 2024-03-09T07:27:59Z |
| format | Article |
| id | doaj.art-27f9d118e34b47da86eb0ea03763dbb2 |
| institution | Directory Open Access Journal |
| issn | 2087-5517 2527-4376 |
| language | English |
| last_indexed | 2024-03-09T07:27:59Z |
| publishDate | 2017-06-01 |
| publisher | University of Brawijaya |
| record_format | Article |
| series | Journal of Tropical Life Science |
| spelling | doaj.art-27f9d118e34b47da86eb0ea03763dbb22023-12-03T06:50:10ZengUniversity of BrawijayaJournal of Tropical Life Science2087-55172527-43762017-06-017210811410.11594/jtls.07.02.04210Prominently Increased of Mannose Binding Lectin (MBL) and Myeloperoxidase (MPO) Levels in Severe Valve Regurgitation and Heart Failure of Rheumatic Heart DiseaseRachmania Putri0Renny Suwarniaty1Loeki Enggar Fitri2Susanto Nugroho3Mohammad Saifur Rahman4Department of Pediatrics, Saiful Anwar Hospital, Faculty of Medicine, Brawijaya UniversityDepartments of Pediatrics, dr. Saiful Anwar General Hospital, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, Indonesia, 65111Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, Indonesia, 65145Departments of Pediatrics, dr. Saiful Anwar General Hospital, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, Indonesia, 65111Departments of Cardiology and Vascular Medicine, dr. Saiful Anwar General Hospital, Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia, 65111Rheumatic heart disease (RHD) is mediated by an abnormal immunological response following a Streptococcus pyogenes infection that induces a disturbance of oxidants and antioxidants balances. Mannose-binding lectin (MBL) binds to N-acetylglucosamine, a molecule present on the Streptococcus cell wall and human heart valves. There is a disturbance of oxidant and antioxidant balance in rheumatic disease. Myeloperoxidase (MPO) is a marker of oxidative stress and inflammation. This study was aimed to determine the correlation of MBL and MPO levels and severity of valvular regurgitation and heart failure (HF) in RHD patients. A case-control study was conduct using human peripheral blood samples from 32 children aged 6 to 14 years old. The subjects were divided into two groups: 16 RHD patients included in the case group and 16 healthy children as a control group. The level of MBL and MPO was investigated using ELISA method. There were significant differences on MBL and MPO level between patient and control group. The level of MBL and MPO were significantly increased in RHD group, especially on severe valvular regurgitation. There was a strong correlation between MBL and MPO levels and the severity of valvular regurgitation (r = 0.94 and r = 0.88). The least significant diff-erence (LSD) analysis showed that significant difference occurs in the severe heart failure group. Our research revealed that the MBL and MPO levels in pediatric RHD patients were significantly higher than in healthy children. The MBL and MPO levels were significantly correlated with the severity of valvular regurgitation and heart failure.http://jtrolis.ub.ac.id/index.php/jtrolis/article/view/615rheumatic heart disease, valvular regurgitation, heart failure, MBL, MPO |
| spellingShingle | Rachmania Putri Renny Suwarniaty Loeki Enggar Fitri Susanto Nugroho Mohammad Saifur Rahman Prominently Increased of Mannose Binding Lectin (MBL) and Myeloperoxidase (MPO) Levels in Severe Valve Regurgitation and Heart Failure of Rheumatic Heart Disease Journal of Tropical Life Science rheumatic heart disease, valvular regurgitation, heart failure, MBL, MPO |
| title | Prominently Increased of Mannose Binding Lectin (MBL) and Myeloperoxidase (MPO) Levels in Severe Valve Regurgitation and Heart Failure of Rheumatic Heart Disease |
| title_full | Prominently Increased of Mannose Binding Lectin (MBL) and Myeloperoxidase (MPO) Levels in Severe Valve Regurgitation and Heart Failure of Rheumatic Heart Disease |
| title_fullStr | Prominently Increased of Mannose Binding Lectin (MBL) and Myeloperoxidase (MPO) Levels in Severe Valve Regurgitation and Heart Failure of Rheumatic Heart Disease |
| title_full_unstemmed | Prominently Increased of Mannose Binding Lectin (MBL) and Myeloperoxidase (MPO) Levels in Severe Valve Regurgitation and Heart Failure of Rheumatic Heart Disease |
| title_short | Prominently Increased of Mannose Binding Lectin (MBL) and Myeloperoxidase (MPO) Levels in Severe Valve Regurgitation and Heart Failure of Rheumatic Heart Disease |
| title_sort | prominently increased of mannose binding lectin mbl and myeloperoxidase mpo levels in severe valve regurgitation and heart failure of rheumatic heart disease |
| topic | rheumatic heart disease, valvular regurgitation, heart failure, MBL, MPO |
| url | http://jtrolis.ub.ac.id/index.php/jtrolis/article/view/615 |
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