Inhibition of MAP4K4 signaling initiates metabolic reprogramming to protect hepatocytes from lipotoxic damage

Inhibition of MAP4K4 signaling initiates metabolic reprogramming to protect hepatocytes from lipotoxic damage

The primary hepatic consequence of obesity is non-alcoholic fatty liver disease (NAFLD), affecting about 25% of the global adult population. Non-alcoholic steatohepatitis (NASH) is a severe form of NAFLD characterized by liver lipid accumulation, inflammation, and hepatocyte ballooning, with a diffe...

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Bibliographic Details
Main Authors: Sumit Kumar Anand, Mara Caputo, Ying Xia, Emma Andersson, Emmelie Cansby, Sima Kumari, Marcus Henricsson, Rando Porosk, Katharina Susanne Keuenhof, Johanna Louise Höög, Syam Nair, Hanns-Ulrich Marschall, Matthias Blüher, Margit Mahlapuu
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Journal of Lipid Research
Subjects:
MAP4K4
non-alcoholic fatty liver disease
non-alcoholic steatohepatitis
liver steatosis
hepatic lipid metabolism
hepatic glycolysis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227522000712

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