IgG subclass deficiency in children with recurrent infections
IgG subclass levels were studied in 12 children, aged between 2.5-12 years with recurrent respiratory tract infections. They did not have low IgG levels or IgA deficiency. We found combined deficiency of IgG2-IgG4 in one patient and selective IgG2 deficiency in another (16.6% of patients). Th...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hacettepe University Institute of Child Health
1991-07-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/3768 |
| _version_ | 1826543339891064832 |
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| author | I Tezcan F Ersoy O Sanal A Göçmen I Yeniay |
| author_facet | I Tezcan F Ersoy O Sanal A Göçmen I Yeniay |
| author_sort | I Tezcan |
| collection | DOAJ |
| description |
IgG subclass levels were studied in 12 children, aged between 2.5-12 years with recurrent respiratory tract infections. They did not have low IgG levels or IgA deficiency. We found combined deficiency of IgG2-IgG4 in one patient and selective IgG2 deficiency in another (16.6% of patients). These two patients had bronchiectasis due to recurrent severe pneumonia, however one patient with bronchiectasis had normal IgG subclass concentrations. Our IgG subclass-deficient patients who did not respond to prophylactic antibiotic therapy were given gammaglobulin therapy. IgG subclass deficiency should be considered in children with unexplained recurrent infections even in the presence of normal serum immunoglobulin levels.
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| first_indexed | 2025-03-14T04:44:31Z |
| format | Article |
| id | doaj.art-27fb5a88a9a84fd9a061d8867b692c55 |
| institution | Directory Open Access Journal |
| issn | 0041-4301 2791-6421 |
| language | English |
| last_indexed | 2025-03-14T04:44:31Z |
| publishDate | 1991-07-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj.art-27fb5a88a9a84fd9a061d8867b692c552025-03-07T19:45:48ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64211991-07-01333IgG subclass deficiency in children with recurrent infectionsI Tezcan0F ErsoyO SanalA GöçmenI YeniayImmunology Unit, Hacettepe University Institute of Child Health, Ankara. IgG subclass levels were studied in 12 children, aged between 2.5-12 years with recurrent respiratory tract infections. They did not have low IgG levels or IgA deficiency. We found combined deficiency of IgG2-IgG4 in one patient and selective IgG2 deficiency in another (16.6% of patients). These two patients had bronchiectasis due to recurrent severe pneumonia, however one patient with bronchiectasis had normal IgG subclass concentrations. Our IgG subclass-deficient patients who did not respond to prophylactic antibiotic therapy were given gammaglobulin therapy. IgG subclass deficiency should be considered in children with unexplained recurrent infections even in the presence of normal serum immunoglobulin levels. https://turkjpediatr.org/article/view/3768 |
| spellingShingle | I Tezcan F Ersoy O Sanal A Göçmen I Yeniay IgG subclass deficiency in children with recurrent infections The Turkish Journal of Pediatrics |
| title | IgG subclass deficiency in children with recurrent infections |
| title_full | IgG subclass deficiency in children with recurrent infections |
| title_fullStr | IgG subclass deficiency in children with recurrent infections |
| title_full_unstemmed | IgG subclass deficiency in children with recurrent infections |
| title_short | IgG subclass deficiency in children with recurrent infections |
| title_sort | igg subclass deficiency in children with recurrent infections |
| url | https://turkjpediatr.org/article/view/3768 |
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