Plumbagin Suppresses Breast Cancer Progression by Downregulating HIF-1α Expression via a PI3K/Akt/mTOR Independent Pathway under Hypoxic Condition

Plumbagin Suppresses Breast Cancer Progression by Downregulating HIF-1α Expression via a PI3K/Akt/mTOR Independent Pathway under Hypoxic Condition

Hypoxia-inducible factor-1α (HIF-1α) is a major transcriptional regulator that plays a crucial role in the hypoxic response of rapidly growing tumors. Overexpression of HIF-1α has been associated with breast cancer metastasis and poor clinical prognosis. Plumbagin, the main phytochemical from <i&...

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Bibliographic Details
Main Authors: Supawan Jampasri, Somrudee Reabroi, Duangjai Tungmunnithum, Warisara Parichatikanond, Darawan Pinthong
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Molecules
Subjects:
plumbagin
hypoxia-inducible factor-1α (HIF-1α)
breast cancer
PI3K/Akt/mTOR pathway
MCF-7 cells
Online Access:https://www.mdpi.com/1420-3049/27/17/5716

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