Characteristics, mechanism, and management of pain in atopic dermatitis: A literature review
Abstract Background Atopic dermatitis (AD) is a chronic, pruritic, immune‐mediated inflammatory disease. Developments in basic science and clinical research have increased our understanding of AD. Although pain as a symptom of AD is underemphasized in previous studies, multiple researchers address p...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-12-01
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| Series: | Clinical and Translational Allergy |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/clt2.12079 |
| _version_ | 1798014816661536768 |
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| author | Jia‐Xin Li Rui‐Jia Dong Yue‐Ping Zeng |
| author_facet | Jia‐Xin Li Rui‐Jia Dong Yue‐Ping Zeng |
| author_sort | Jia‐Xin Li |
| collection | DOAJ |
| description | Abstract Background Atopic dermatitis (AD) is a chronic, pruritic, immune‐mediated inflammatory disease. Developments in basic science and clinical research have increased our understanding of AD. Although pain as a symptom of AD is underemphasized in previous studies, multiple researchers address pain as a frequent burden of AD. However, the exact role of pain in AD is not fully understood. Aims Our review aimed to summarize the current evidence focusing on characteristics, mechanism, and management of pain in AD. Materials & Methods We conducted a thorough literature review in the PubMed database to figure out different aspects discussing pain in AD, including pain symptoms, burden, the relationship between pain and itch, mechanism, and pain management in AD. Results and Conclusion AD patients affected by skin pain vary from 42.7%‐92.2% with remarkable intensity and heavy burden. Skin pain and itch interacted both in symptoms and mechanisms. Atopic skin with the impaired barrier, neurogenic inflammation mediators, peripheral and central sensitization of pain may possibly explain pain mechanism in AD. Future research is needed to clarify the commonality and disparity of pain and itch in AD in order to seek efficacious medications and treatment. |
| first_indexed | 2024-04-11T15:24:26Z |
| format | Article |
| id | doaj.art-27fca4736e82486fad76f48f99ee5f51 |
| institution | Directory Open Access Journal |
| issn | 2045-7022 |
| language | English |
| last_indexed | 2024-04-11T15:24:26Z |
| publishDate | 2021-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Allergy |
| spelling | doaj.art-27fca4736e82486fad76f48f99ee5f512022-12-22T04:16:17ZengWileyClinical and Translational Allergy2045-70222021-12-011110n/an/a10.1002/clt2.12079Characteristics, mechanism, and management of pain in atopic dermatitis: A literature reviewJia‐Xin Li0Rui‐Jia Dong1Yue‐Ping Zeng2Department of Dermatology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases Beijing ChinaDepartment of Plastic Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine Tsinghua University Beijing ChinaDepartment of Dermatology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases Beijing ChinaAbstract Background Atopic dermatitis (AD) is a chronic, pruritic, immune‐mediated inflammatory disease. Developments in basic science and clinical research have increased our understanding of AD. Although pain as a symptom of AD is underemphasized in previous studies, multiple researchers address pain as a frequent burden of AD. However, the exact role of pain in AD is not fully understood. Aims Our review aimed to summarize the current evidence focusing on characteristics, mechanism, and management of pain in AD. Materials & Methods We conducted a thorough literature review in the PubMed database to figure out different aspects discussing pain in AD, including pain symptoms, burden, the relationship between pain and itch, mechanism, and pain management in AD. Results and Conclusion AD patients affected by skin pain vary from 42.7%‐92.2% with remarkable intensity and heavy burden. Skin pain and itch interacted both in symptoms and mechanisms. Atopic skin with the impaired barrier, neurogenic inflammation mediators, peripheral and central sensitization of pain may possibly explain pain mechanism in AD. Future research is needed to clarify the commonality and disparity of pain and itch in AD in order to seek efficacious medications and treatment.https://doi.org/10.1002/clt2.12079atopische dermatitisepidemiologiemanagementmechanismusschmerzen |
| spellingShingle | Jia‐Xin Li Rui‐Jia Dong Yue‐Ping Zeng Characteristics, mechanism, and management of pain in atopic dermatitis: A literature review Clinical and Translational Allergy atopische dermatitis epidemiologie management mechanismus schmerzen |
| title | Characteristics, mechanism, and management of pain in atopic dermatitis: A literature review |
| title_full | Characteristics, mechanism, and management of pain in atopic dermatitis: A literature review |
| title_fullStr | Characteristics, mechanism, and management of pain in atopic dermatitis: A literature review |
| title_full_unstemmed | Characteristics, mechanism, and management of pain in atopic dermatitis: A literature review |
| title_short | Characteristics, mechanism, and management of pain in atopic dermatitis: A literature review |
| title_sort | characteristics mechanism and management of pain in atopic dermatitis a literature review |
| topic | atopische dermatitis epidemiologie management mechanismus schmerzen |
| url | https://doi.org/10.1002/clt2.12079 |
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