Process- and Product-Related Foulants in Virus Filtration

Process- and Product-Related Foulants in Virus Filtration

Regulatory authorities place stringent guidelines on the removal of contaminants during the manufacture of biopharmaceutical products. Monoclonal antibodies, Fc-fusion proteins, and other mammalian cell-derived biotherapeutics are heterogeneous molecules that are validated based on the production pr...

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Bibliographic Details
Main Authors: Solomon Isu, Xianghong Qian, Andrew L. Zydney, S. Ranil Wickramasinghe
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Bioengineering
Subjects:
aggregation
charge variant
downstream processing
fusion protein
foulant
glycoform
Online Access:https://www.mdpi.com/2306-5354/9/4/155

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