Fucoidan modulates SIRT1 and NLRP3 to alleviate hypertensive retinopathy: in vivo and in vitro insights

Fucoidan modulates SIRT1 and NLRP3 to alleviate hypertensive retinopathy: in vivo and in vitro insights

Abstract Background Hypertension influences the inflammatory pathological changes in the retina. The function of the inflammasomes is significant. To see if Sirtuin 1 (SIRT1) regulates angiotensin II (Ang II)-induced hypertensive retinopathy and inflammation by modulating NOD-like receptor thermal p...

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Bibliographic Details
Main Authors: Jing Li, Xiaochen Wang, Jie Bai, Huangzhao Wei, Wenbo Wang, Shuai Wang
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Journal of Translational Medicine
Subjects:
Hypertensive retinopathy
SIRT1
NLRP3 inflammasome
Fucoidan therapeutic potential
Online Access:https://doi.org/10.1186/s12967-024-04877-6

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