A clinical trial about effects of prebiotic and probiotic supplementation on weight loss, psychological profile and metabolic parameters in obese subjects
Abstract Introduction The management of obesity is difficult with many failures of lifestyle measures, hence the need to broaden the range of treatments prescribed. The aim of our work was to study the influence of pre and probiotics on weight loss psychological profile and metabolic parameters in o...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-03-01
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| Series: | Endocrinology, Diabetes & Metabolism |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/edm2.402 |
| _version_ | 1811154954734272512 |
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| author | Rym Ben Othman Nadia Ben Amor Faten Mahjoub Olfa Berriche Chaima El Ghali Amel Gamoudi Henda Jamoussi |
| author_facet | Rym Ben Othman Nadia Ben Amor Faten Mahjoub Olfa Berriche Chaima El Ghali Amel Gamoudi Henda Jamoussi |
| author_sort | Rym Ben Othman |
| collection | DOAJ |
| description | Abstract Introduction The management of obesity is difficult with many failures of lifestyle measures, hence the need to broaden the range of treatments prescribed. The aim of our work was to study the influence of pre and probiotics on weight loss psychological profile and metabolic parameters in obese patients. Methods It is a clinical trial involving 45 obese patients, recruited from the Obesity Unit of the National Institute of Nutrition between March and August 2022 divided into three groups: diet only (low‐carbohydrate and reduced energy diet), prebiotics (30 g of carob/day) and probiotics (one tablet containing Bifidobacterium longum, Lactobacillus helveticus, Lactococcus lactis, Streptococcus thermophilus/day). The three groups were matched for age, sex and BMI. Patients were seen after 1 month from the intervention. Anthropometric measures, biological parameters, dietary survey and psychological scores were performed. Results The average age of our population was 48.73 ± 7.7 years, with a female predominance. All three groups showed a significant decrease in weight, BMI and waist circumference with p < .05. Only the prebiotic and probiotic group showed a significant decrease in fat mass (p = .001) and a significant increase in muscle strength with p = .008 and .004, but the differences were not significant between the three groups. Our results showed also a significant decrease in insulinemia and HOMA‐IR in the prebiotic group compared to the diet‐alone group (p = .03; p = .012) and the probiotic group showed a significant decrease in fasting blood glucose compared to the diet alone group (p = .02). A significant improvement in sleep quality was noted in the prebiotic group (p = .02), with a significant decrease in depression, anxiety and stress in all three groups. Conclusions The prescription of prebiotics and probiotics with the lifestyle measures seems interesting for the management of obesity especially if it is sarcopenic, in addition to the improvement of metabolic parameters and obesity‐related psychiatric disorders. |
| first_indexed | 2024-04-10T04:25:50Z |
| format | Article |
| id | doaj.art-2802d78010664189bce86753b56c8433 |
| institution | Directory Open Access Journal |
| issn | 2398-9238 |
| language | English |
| last_indexed | 2024-04-10T04:25:50Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Endocrinology, Diabetes & Metabolism |
| spelling | doaj.art-2802d78010664189bce86753b56c84332023-03-10T14:33:25ZengWileyEndocrinology, Diabetes & Metabolism2398-92382023-03-0162n/an/a10.1002/edm2.402A clinical trial about effects of prebiotic and probiotic supplementation on weight loss, psychological profile and metabolic parameters in obese subjectsRym Ben Othman0Nadia Ben Amor1Faten Mahjoub2Olfa Berriche3Chaima El Ghali4Amel Gamoudi5Henda Jamoussi6Faculty of Medicine of Tunis Institute National de Nutrition et de Technologie Alimentaire de Tunis and University of Tunis el Manar Tunis TunisiaFaculty of Medicine of Tunis Institute National de Nutrition et de Technologie Alimentaire de Tunis and University of Tunis el Manar Tunis TunisiaFaculty of Medicine of Tunis Institute National de Nutrition et de Technologie Alimentaire de Tunis and University of Tunis el Manar Tunis TunisiaFaculty of Medicine of Tunis Institute National de Nutrition et de Technologie Alimentaire de Tunis and University of Tunis el Manar Tunis TunisiaFaculty of Medicine of Tunis Institute National de Nutrition et de Technologie Alimentaire de Tunis and University of Tunis el Manar Tunis TunisiaFaculty of Medicine of Tunis Institute National de Nutrition et de Technologie Alimentaire de Tunis and University of Tunis el Manar Tunis TunisiaFaculty of Medicine of Tunis Institute National de Nutrition et de Technologie Alimentaire de Tunis and University of Tunis el Manar Tunis TunisiaAbstract Introduction The management of obesity is difficult with many failures of lifestyle measures, hence the need to broaden the range of treatments prescribed. The aim of our work was to study the influence of pre and probiotics on weight loss psychological profile and metabolic parameters in obese patients. Methods It is a clinical trial involving 45 obese patients, recruited from the Obesity Unit of the National Institute of Nutrition between March and August 2022 divided into three groups: diet only (low‐carbohydrate and reduced energy diet), prebiotics (30 g of carob/day) and probiotics (one tablet containing Bifidobacterium longum, Lactobacillus helveticus, Lactococcus lactis, Streptococcus thermophilus/day). The three groups were matched for age, sex and BMI. Patients were seen after 1 month from the intervention. Anthropometric measures, biological parameters, dietary survey and psychological scores were performed. Results The average age of our population was 48.73 ± 7.7 years, with a female predominance. All three groups showed a significant decrease in weight, BMI and waist circumference with p < .05. Only the prebiotic and probiotic group showed a significant decrease in fat mass (p = .001) and a significant increase in muscle strength with p = .008 and .004, but the differences were not significant between the three groups. Our results showed also a significant decrease in insulinemia and HOMA‐IR in the prebiotic group compared to the diet‐alone group (p = .03; p = .012) and the probiotic group showed a significant decrease in fasting blood glucose compared to the diet alone group (p = .02). A significant improvement in sleep quality was noted in the prebiotic group (p = .02), with a significant decrease in depression, anxiety and stress in all three groups. Conclusions The prescription of prebiotics and probiotics with the lifestyle measures seems interesting for the management of obesity especially if it is sarcopenic, in addition to the improvement of metabolic parameters and obesity‐related psychiatric disorders.https://doi.org/10.1002/edm2.402obesityprebioticsprobioticsweight loss |
| spellingShingle | Rym Ben Othman Nadia Ben Amor Faten Mahjoub Olfa Berriche Chaima El Ghali Amel Gamoudi Henda Jamoussi A clinical trial about effects of prebiotic and probiotic supplementation on weight loss, psychological profile and metabolic parameters in obese subjects Endocrinology, Diabetes & Metabolism obesity prebiotics probiotics weight loss |
| title | A clinical trial about effects of prebiotic and probiotic supplementation on weight loss, psychological profile and metabolic parameters in obese subjects |
| title_full | A clinical trial about effects of prebiotic and probiotic supplementation on weight loss, psychological profile and metabolic parameters in obese subjects |
| title_fullStr | A clinical trial about effects of prebiotic and probiotic supplementation on weight loss, psychological profile and metabolic parameters in obese subjects |
| title_full_unstemmed | A clinical trial about effects of prebiotic and probiotic supplementation on weight loss, psychological profile and metabolic parameters in obese subjects |
| title_short | A clinical trial about effects of prebiotic and probiotic supplementation on weight loss, psychological profile and metabolic parameters in obese subjects |
| title_sort | clinical trial about effects of prebiotic and probiotic supplementation on weight loss psychological profile and metabolic parameters in obese subjects |
| topic | obesity prebiotics probiotics weight loss |
| url | https://doi.org/10.1002/edm2.402 |
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