One pot chemo/enzymatic synthesis of chiral δ-substituent caprolactam and its configuration controlling(手性δ-取代己内酰胺化学/酶串联一锅法合成及立体构型调控)

One pot chemo/enzymatic synthesis of chiral δ-substituent caprolactam and its configuration controlling(手性δ-取代己内酰胺化学/酶串联一锅法合成及立体构型调控)

Herein, a novel one pot synthesis of chiral δ-substituent caprolactam strategy which applies 1-substituent homoallylic amine as the starting material is reported. This method combines the enzymatic dynamic kinetic resolution (DKR) and ring cross metathesis. Moreover, the configuration of caprolactam...

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Bibliographic Details
Main Authors: 屠美玲(TU Meiling), 王祁宁(WANG Qining), 李琰君(LI Yanjun), 张建庭(ZHANG Jianting), 贾继宁(JIA Jining), 杨阿三(YANG Asan)
Format: Article
Language:zho
Published: Zhejiang University Press 2024-01-01
Series:Zhejiang Daxue xuebao. Lixue ban
Subjects:
chiral caprolactam(手性己内酰胺)
configuration-controlling synthesis(立体构型可调控合成)
one pot chemo/enzymatic synthesis(化学/酶串联一锅法合成)
Online Access:https://doi.org/10.3785/j.issn.1008-9497.2024.01.007

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