The effects of fish oil omega-3 fatty acid supplementation on mental health parameters and metabolic status of patients with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial
Objective This study was conducted to evaluate the effects of fish oil omega-3 fatty acid supplementation on mental health parameters and metabolic status of women with polycystic ovary syndrome (PCOS). Methods This randomized double-blind, placebo-controlled trial was conducted on 60 women with PCO...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-10-01
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| Series: | Journal of Psychosomatic Obstetrics and Gynecology |
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| Online Access: | http://dx.doi.org/10.1080/0167482X.2018.1508282 |
| _version_ | 1797685823140790272 |
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| author | Mehrdad Amini Fereshteh Bahmani Fatemeh Foroozanfard Zahra Vahedpoor Amir Ghaderi Mohsen Taghizadeh Hassan Karbassizadeh Zatollah Asemi |
| author_facet | Mehrdad Amini Fereshteh Bahmani Fatemeh Foroozanfard Zahra Vahedpoor Amir Ghaderi Mohsen Taghizadeh Hassan Karbassizadeh Zatollah Asemi |
| author_sort | Mehrdad Amini |
| collection | DOAJ |
| description | Objective This study was conducted to evaluate the effects of fish oil omega-3 fatty acid supplementation on mental health parameters and metabolic status of women with polycystic ovary syndrome (PCOS). Methods This randomized double-blind, placebo-controlled trial was conducted on 60 women with PCOS, aged 18–40 years old. Participants were randomly assigned into two groups to receive either 2 × 1000 mg/day fish oil omega-3 fatty acid (n = 30) or placebo (n = 30) after lunch for 12 weeks. Metabolic profiles were quantified at baseline and after the 12-week intervention. Results Compared with the placebo, omega-3 fatty acid intake led to a significant improvement in Beck Depression Inventory [β (difference in the mean outcomes measures between treatment groups after intervention) –1.05; 95% CI: –1.84, –0.26; p = .01], general health questionnaire (β –1.68; 95% CI: –3.12, –0.24; p = .02) and depression anxiety and stress scale (β –2.03; 95% CI: –3.60, –0.46; p = .01). Omega-3 fatty acid supplementation significantly decreased serum insulin levels (β –2.09 µIU/mL; 95% CI: –3.77, –0.41; p = .01), homeostasis model of assessment-insulin resistance (β –0.74; 95% CI: –1.13, –0.34; p < .001), total testosterone (β –0.23 ng/mL; 95% CI: –0.39, –0.06; p = .03) and hirsutism (β –0.75; 95% CI: –1.17, –0.33; p = .001), and significantly increased the quantitative insulin sensitivity check index (β 0.01; 95% CI: 0.003, 0.02; p = .008) compared with the placebo. Additionally, omega-3 fatty acid intake resulted in a significant decrease in high sensitivity C-reactive protein (β –1.46 mg/L; 95% CI: –2.16, –0.75; p < .001) and malondialdehyde (β –0.28 µmol/L; 95% CI: –0.52, –0.05; p = .03); also significant rises in plasma total glutathione (β 59.09 µmol/L; 95% CI: 7.07, 111.11; p = .02) was observed compared with the placebo. Omega-3 fatty acid supplementation did not change other metabolic parameters. Conclusion Overall, omega-3 fatty acid supplementation for 12 weeks to patients with PCOS had beneficial effects on mental health parameters, insulin metabolism, total testosterone, hirsutism and few inflammatory markers and oxidative stress. |
| first_indexed | 2024-03-12T00:56:55Z |
| format | Article |
| id | doaj.art-2804e9d1f3ab42a6ab4b3003dea5042c |
| institution | Directory Open Access Journal |
| issn | 0167-482X 1743-8942 |
| language | English |
| last_indexed | 2024-03-12T00:56:55Z |
| publishDate | 2020-10-01 |
| publisher | Taylor & Francis Group |
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| series | Journal of Psychosomatic Obstetrics and Gynecology |
| spelling | doaj.art-2804e9d1f3ab42a6ab4b3003dea5042c2023-09-14T12:44:00ZengTaylor & Francis GroupJournal of Psychosomatic Obstetrics and Gynecology0167-482X1743-89422020-10-01001910.1080/0167482X.2018.15082821508282The effects of fish oil omega-3 fatty acid supplementation on mental health parameters and metabolic status of patients with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trialMehrdad Amini0Fereshteh Bahmani1Fatemeh Foroozanfard2Zahra Vahedpoor3Amir Ghaderi4Mohsen Taghizadeh5Hassan Karbassizadeh6Zatollah Asemi7Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical SciencesResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical SciencesDepartment of Gynecology and Obstetrics, School of Medicine, Kashan University of Medical SciencesDepartment of Gynecology and Obstetrics, School of Medicine, Kashan University of Medical SciencesDepartment of Addiction studies, School of Medical, Kashan University of Medical SciencesResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical SciencesBarij Medicinal Plants Research CenterResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical SciencesObjective This study was conducted to evaluate the effects of fish oil omega-3 fatty acid supplementation on mental health parameters and metabolic status of women with polycystic ovary syndrome (PCOS). Methods This randomized double-blind, placebo-controlled trial was conducted on 60 women with PCOS, aged 18–40 years old. Participants were randomly assigned into two groups to receive either 2 × 1000 mg/day fish oil omega-3 fatty acid (n = 30) or placebo (n = 30) after lunch for 12 weeks. Metabolic profiles were quantified at baseline and after the 12-week intervention. Results Compared with the placebo, omega-3 fatty acid intake led to a significant improvement in Beck Depression Inventory [β (difference in the mean outcomes measures between treatment groups after intervention) –1.05; 95% CI: –1.84, –0.26; p = .01], general health questionnaire (β –1.68; 95% CI: –3.12, –0.24; p = .02) and depression anxiety and stress scale (β –2.03; 95% CI: –3.60, –0.46; p = .01). Omega-3 fatty acid supplementation significantly decreased serum insulin levels (β –2.09 µIU/mL; 95% CI: –3.77, –0.41; p = .01), homeostasis model of assessment-insulin resistance (β –0.74; 95% CI: –1.13, –0.34; p < .001), total testosterone (β –0.23 ng/mL; 95% CI: –0.39, –0.06; p = .03) and hirsutism (β –0.75; 95% CI: –1.17, –0.33; p = .001), and significantly increased the quantitative insulin sensitivity check index (β 0.01; 95% CI: 0.003, 0.02; p = .008) compared with the placebo. Additionally, omega-3 fatty acid intake resulted in a significant decrease in high sensitivity C-reactive protein (β –1.46 mg/L; 95% CI: –2.16, –0.75; p < .001) and malondialdehyde (β –0.28 µmol/L; 95% CI: –0.52, –0.05; p = .03); also significant rises in plasma total glutathione (β 59.09 µmol/L; 95% CI: 7.07, 111.11; p = .02) was observed compared with the placebo. Omega-3 fatty acid supplementation did not change other metabolic parameters. Conclusion Overall, omega-3 fatty acid supplementation for 12 weeks to patients with PCOS had beneficial effects on mental health parameters, insulin metabolism, total testosterone, hirsutism and few inflammatory markers and oxidative stress.http://dx.doi.org/10.1080/0167482X.2018.1508282omega-3 fatty acid supplementationmental healthmetabolic statuspolycystic ovary syndrome |
| spellingShingle | Mehrdad Amini Fereshteh Bahmani Fatemeh Foroozanfard Zahra Vahedpoor Amir Ghaderi Mohsen Taghizadeh Hassan Karbassizadeh Zatollah Asemi The effects of fish oil omega-3 fatty acid supplementation on mental health parameters and metabolic status of patients with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial Journal of Psychosomatic Obstetrics and Gynecology omega-3 fatty acid supplementation mental health metabolic status polycystic ovary syndrome |
| title | The effects of fish oil omega-3 fatty acid supplementation on mental health parameters and metabolic status of patients with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial |
| title_full | The effects of fish oil omega-3 fatty acid supplementation on mental health parameters and metabolic status of patients with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial |
| title_fullStr | The effects of fish oil omega-3 fatty acid supplementation on mental health parameters and metabolic status of patients with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial |
| title_full_unstemmed | The effects of fish oil omega-3 fatty acid supplementation on mental health parameters and metabolic status of patients with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial |
| title_short | The effects of fish oil omega-3 fatty acid supplementation on mental health parameters and metabolic status of patients with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial |
| title_sort | effects of fish oil omega 3 fatty acid supplementation on mental health parameters and metabolic status of patients with polycystic ovary syndrome a randomized double blind placebo controlled trial |
| topic | omega-3 fatty acid supplementation mental health metabolic status polycystic ovary syndrome |
| url | http://dx.doi.org/10.1080/0167482X.2018.1508282 |
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