MiRNA-Based Therapies for Lung Cancer: Opportunities and Challenges?
Lung cancer is a commonly diagnosed cancer and the leading cause of cancer-related deaths, posing a serious health risk. Despite new advances in immune checkpoint and targeted therapies in recent years, the prognosis for lung cancer patients, especially those in advanced stages, remains poor. MicroR...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/6/877 |
| _version_ | 1797595796776943616 |
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| author | Han Yang Yufang Liu Longqing Chen Juanjuan Zhao Mengmeng Guo Xu Zhao Zhenke Wen Zhixu He Chao Chen Lin Xu |
| author_facet | Han Yang Yufang Liu Longqing Chen Juanjuan Zhao Mengmeng Guo Xu Zhao Zhenke Wen Zhixu He Chao Chen Lin Xu |
| author_sort | Han Yang |
| collection | DOAJ |
| description | Lung cancer is a commonly diagnosed cancer and the leading cause of cancer-related deaths, posing a serious health risk. Despite new advances in immune checkpoint and targeted therapies in recent years, the prognosis for lung cancer patients, especially those in advanced stages, remains poor. MicroRNAs (miRNAs) have been shown to modulate tumor development at multiple levels, and as such, miRNA mimics and molecules aimed at regulating miRNAs have shown promise in preclinical development. More importantly, miRNA-based therapies can also complement conventional chemoradiotherapy, immunotherapy, and targeted therapies to reverse drug resistance and increase the sensitivity of lung cancer cells. Furthermore, small interfering RNA (siRNA) and miRNA-based therapies have entered clinical trials and have shown favorable development prospects. Therefore, in this paper, we review recent advances in miRNA-based therapies in lung cancer treatment as well as adjuvant therapy and present the current state of clinical lung cancer treatment. We also discuss the challenges facing miRNA-based therapies in the clinical application of lung cancer treatment to provide new ideas for the development of novel lung cancer therapies. |
| first_indexed | 2024-03-11T02:42:31Z |
| format | Article |
| id | doaj.art-28064dc4432341ad9dce41cdf43365e5 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T02:42:31Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-28064dc4432341ad9dce41cdf43365e52023-11-18T09:30:05ZengMDPI AGBiomolecules2218-273X2023-05-0113687710.3390/biom13060877MiRNA-Based Therapies for Lung Cancer: Opportunities and Challenges?Han Yang0Yufang Liu1Longqing Chen2Juanjuan Zhao3Mengmeng Guo4Xu Zhao5Zhenke Wen6Zhixu He7Chao Chen8Lin Xu9Special Key Laboratory of Gene Detection and Therapy of Guizhou Province, Zunyi Medical University, Zunyi 563000, ChinaSpecial Key Laboratory of Gene Detection and Therapy of Guizhou Province, Zunyi Medical University, Zunyi 563000, ChinaSpecial Key Laboratory of Gene Detection and Therapy of Guizhou Province, Zunyi Medical University, Zunyi 563000, ChinaSpecial Key Laboratory of Gene Detection and Therapy of Guizhou Province, Zunyi Medical University, Zunyi 563000, ChinaSpecial Key Laboratory of Gene Detection and Therapy of Guizhou Province, Zunyi Medical University, Zunyi 563000, ChinaSpecial Key Laboratory of Gene Detection and Therapy of Guizhou Province, Zunyi Medical University, Zunyi 563000, ChinaInstitute of Biomedical Research, Soochow University, Soochow 563000, ChinaCollaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi 563000, ChinaSpecial Key Laboratory of Gene Detection and Therapy of Guizhou Province, Zunyi Medical University, Zunyi 563000, ChinaSpecial Key Laboratory of Gene Detection and Therapy of Guizhou Province, Zunyi Medical University, Zunyi 563000, ChinaLung cancer is a commonly diagnosed cancer and the leading cause of cancer-related deaths, posing a serious health risk. Despite new advances in immune checkpoint and targeted therapies in recent years, the prognosis for lung cancer patients, especially those in advanced stages, remains poor. MicroRNAs (miRNAs) have been shown to modulate tumor development at multiple levels, and as such, miRNA mimics and molecules aimed at regulating miRNAs have shown promise in preclinical development. More importantly, miRNA-based therapies can also complement conventional chemoradiotherapy, immunotherapy, and targeted therapies to reverse drug resistance and increase the sensitivity of lung cancer cells. Furthermore, small interfering RNA (siRNA) and miRNA-based therapies have entered clinical trials and have shown favorable development prospects. Therefore, in this paper, we review recent advances in miRNA-based therapies in lung cancer treatment as well as adjuvant therapy and present the current state of clinical lung cancer treatment. We also discuss the challenges facing miRNA-based therapies in the clinical application of lung cancer treatment to provide new ideas for the development of novel lung cancer therapies.https://www.mdpi.com/2218-273X/13/6/877microRNAslung cancerchemoradiotherapytargeted therapyimmunotherapyMiRNA-based therapy |
| spellingShingle | Han Yang Yufang Liu Longqing Chen Juanjuan Zhao Mengmeng Guo Xu Zhao Zhenke Wen Zhixu He Chao Chen Lin Xu MiRNA-Based Therapies for Lung Cancer: Opportunities and Challenges? Biomolecules microRNAs lung cancer chemoradiotherapy targeted therapy immunotherapy MiRNA-based therapy |
| title | MiRNA-Based Therapies for Lung Cancer: Opportunities and Challenges? |
| title_full | MiRNA-Based Therapies for Lung Cancer: Opportunities and Challenges? |
| title_fullStr | MiRNA-Based Therapies for Lung Cancer: Opportunities and Challenges? |
| title_full_unstemmed | MiRNA-Based Therapies for Lung Cancer: Opportunities and Challenges? |
| title_short | MiRNA-Based Therapies for Lung Cancer: Opportunities and Challenges? |
| title_sort | mirna based therapies for lung cancer opportunities and challenges |
| topic | microRNAs lung cancer chemoradiotherapy targeted therapy immunotherapy MiRNA-based therapy |
| url | https://www.mdpi.com/2218-273X/13/6/877 |
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