Adipose tissue macrophages as potential targets for obesity and metabolic diseases
Macrophage infiltration into adipose tissue is a key pathological factor inducing adipose tissue dysfunction and contributing to obesity-induced inflammation and metabolic disorders. In this review, we aim to present the most recent research on macrophage heterogeneity in adipose tissue, with a focu...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-04-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1153915/full |
| _version_ | 1797844241786863616 |
|---|---|
| author | Xirong Li Yakun Ren Kewei Chang Kewei Chang Kewei Chang Wenlong Wu Helen R. Griffiths Shemin Lu Shemin Lu Shemin Lu Dan Gao Dan Gao Dan Gao |
| author_facet | Xirong Li Yakun Ren Kewei Chang Kewei Chang Kewei Chang Wenlong Wu Helen R. Griffiths Shemin Lu Shemin Lu Shemin Lu Dan Gao Dan Gao Dan Gao |
| author_sort | Xirong Li |
| collection | DOAJ |
| description | Macrophage infiltration into adipose tissue is a key pathological factor inducing adipose tissue dysfunction and contributing to obesity-induced inflammation and metabolic disorders. In this review, we aim to present the most recent research on macrophage heterogeneity in adipose tissue, with a focus on the molecular targets applied to macrophages as potential therapeutics for metabolic diseases. We begin by discussing the recruitment of macrophages and their roles in adipose tissue. While resident adipose tissue macrophages display an anti-inflammatory phenotype and promote the development of metabolically favorable beige adipose tissue, an increase in pro-inflammatory macrophages in adipose tissue has negative effects on adipose tissue function, including inhibition of adipogenesis, promotion of inflammation, insulin resistance, and fibrosis. Then, we presented the identities of the newly discovered adipose tissue macrophage subtypes (e.g. metabolically activated macrophages, CD9+ macrophages, lipid-associated macrophages, DARC+ macrophages, and MFehi macrophages), the majority of which are located in crown-like structures within adipose tissue during obesity. Finally, we discussed macrophage-targeting strategies to ameliorate obesity-related inflammation and metabolic abnormalities, with a focus on transcriptional factors such as PPARγ, KLF4, NFATc3, and HoxA5, which promote macrophage anti-inflammatory M2 polarization, as well as TLR4/NF-κB-mediated inflammatory pathways that activate pro-inflammatory M1 macrophages. In addition, a number of intracellular metabolic pathways closely associated with glucose metabolism, oxidative stress, nutrient sensing, and circadian clock regulation were examined. Understanding the complexities of macrophage plasticity and functionality may open up new avenues for the development of macrophage-based treatments for obesity and other metabolic diseases. |
| first_indexed | 2024-04-09T17:19:08Z |
| format | Article |
| id | doaj.art-280f324119224b47b347699e74da9a81 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-09T17:19:08Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-280f324119224b47b347699e74da9a812023-04-19T05:00:43ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-04-011410.3389/fimmu.2023.11539151153915Adipose tissue macrophages as potential targets for obesity and metabolic diseasesXirong Li0Yakun Ren1Kewei Chang2Kewei Chang3Kewei Chang4Wenlong Wu5Helen R. Griffiths6Shemin Lu7Shemin Lu8Shemin Lu9Dan Gao10Dan Gao11Dan Gao12Institute of Molecular and Translational Medicine, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an, ChinaInstitute of Molecular and Translational Medicine, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an, ChinaInstitute of Molecular and Translational Medicine, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an, ChinaKey Laboratory of Environment and Genes Related to Diseases (Xi’an Jiaotong University), Ministry of Education, Xi’an, ChinaDepartment of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Center, Xi’an, ChinaInstitute of Molecular and Translational Medicine, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an, ChinaSwansea University Medical School, Swansea University, Swansea, United KingdomInstitute of Molecular and Translational Medicine, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an, ChinaKey Laboratory of Environment and Genes Related to Diseases (Xi’an Jiaotong University), Ministry of Education, Xi’an, ChinaDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an, ChinaInstitute of Molecular and Translational Medicine, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an, ChinaKey Laboratory of Environment and Genes Related to Diseases (Xi’an Jiaotong University), Ministry of Education, Xi’an, ChinaDepartment of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Center, Xi’an, ChinaMacrophage infiltration into adipose tissue is a key pathological factor inducing adipose tissue dysfunction and contributing to obesity-induced inflammation and metabolic disorders. In this review, we aim to present the most recent research on macrophage heterogeneity in adipose tissue, with a focus on the molecular targets applied to macrophages as potential therapeutics for metabolic diseases. We begin by discussing the recruitment of macrophages and their roles in adipose tissue. While resident adipose tissue macrophages display an anti-inflammatory phenotype and promote the development of metabolically favorable beige adipose tissue, an increase in pro-inflammatory macrophages in adipose tissue has negative effects on adipose tissue function, including inhibition of adipogenesis, promotion of inflammation, insulin resistance, and fibrosis. Then, we presented the identities of the newly discovered adipose tissue macrophage subtypes (e.g. metabolically activated macrophages, CD9+ macrophages, lipid-associated macrophages, DARC+ macrophages, and MFehi macrophages), the majority of which are located in crown-like structures within adipose tissue during obesity. Finally, we discussed macrophage-targeting strategies to ameliorate obesity-related inflammation and metabolic abnormalities, with a focus on transcriptional factors such as PPARγ, KLF4, NFATc3, and HoxA5, which promote macrophage anti-inflammatory M2 polarization, as well as TLR4/NF-κB-mediated inflammatory pathways that activate pro-inflammatory M1 macrophages. In addition, a number of intracellular metabolic pathways closely associated with glucose metabolism, oxidative stress, nutrient sensing, and circadian clock regulation were examined. Understanding the complexities of macrophage plasticity and functionality may open up new avenues for the development of macrophage-based treatments for obesity and other metabolic diseases.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1153915/fullmacrophagesadipose tissueplasticityobesitymetabolic diseases |
| spellingShingle | Xirong Li Yakun Ren Kewei Chang Kewei Chang Kewei Chang Wenlong Wu Helen R. Griffiths Shemin Lu Shemin Lu Shemin Lu Dan Gao Dan Gao Dan Gao Adipose tissue macrophages as potential targets for obesity and metabolic diseases Frontiers in Immunology macrophages adipose tissue plasticity obesity metabolic diseases |
| title | Adipose tissue macrophages as potential targets for obesity and metabolic diseases |
| title_full | Adipose tissue macrophages as potential targets for obesity and metabolic diseases |
| title_fullStr | Adipose tissue macrophages as potential targets for obesity and metabolic diseases |
| title_full_unstemmed | Adipose tissue macrophages as potential targets for obesity and metabolic diseases |
| title_short | Adipose tissue macrophages as potential targets for obesity and metabolic diseases |
| title_sort | adipose tissue macrophages as potential targets for obesity and metabolic diseases |
| topic | macrophages adipose tissue plasticity obesity metabolic diseases |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1153915/full |
| work_keys_str_mv | AT xirongli adiposetissuemacrophagesaspotentialtargetsforobesityandmetabolicdiseases AT yakunren adiposetissuemacrophagesaspotentialtargetsforobesityandmetabolicdiseases AT keweichang adiposetissuemacrophagesaspotentialtargetsforobesityandmetabolicdiseases AT keweichang adiposetissuemacrophagesaspotentialtargetsforobesityandmetabolicdiseases AT keweichang adiposetissuemacrophagesaspotentialtargetsforobesityandmetabolicdiseases AT wenlongwu adiposetissuemacrophagesaspotentialtargetsforobesityandmetabolicdiseases AT helenrgriffiths adiposetissuemacrophagesaspotentialtargetsforobesityandmetabolicdiseases AT sheminlu adiposetissuemacrophagesaspotentialtargetsforobesityandmetabolicdiseases AT sheminlu adiposetissuemacrophagesaspotentialtargetsforobesityandmetabolicdiseases AT sheminlu adiposetissuemacrophagesaspotentialtargetsforobesityandmetabolicdiseases AT dangao adiposetissuemacrophagesaspotentialtargetsforobesityandmetabolicdiseases AT dangao adiposetissuemacrophagesaspotentialtargetsforobesityandmetabolicdiseases AT dangao adiposetissuemacrophagesaspotentialtargetsforobesityandmetabolicdiseases |