Descemet's membrane endothelial keratoplasty (DMEK) rejection following COVID-19 infection: A case report
Purpose: To report the first known case of Descemet's Membrane Endothelial Keratoplasty (DMEK) graft rejection following COVID19 infection. Observation: A 60-year-old woman with a history of DMEK for Fuch's dystrophy, presented with redness and vision loss in her operated eye 18 months aft...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-09-01
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| Series: | American Journal of Ophthalmology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S245199362100147X |
| _version_ | 1818612511137595392 |
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| author | Karen Bitton Mathieu Dubois Romain Courtin Christophe Panthier Damien Gatinel |
| author_facet | Karen Bitton Mathieu Dubois Romain Courtin Christophe Panthier Damien Gatinel |
| author_sort | Karen Bitton |
| collection | DOAJ |
| description | Purpose: To report the first known case of Descemet's Membrane Endothelial Keratoplasty (DMEK) graft rejection following COVID19 infection. Observation: A 60-year-old woman with a history of DMEK for Fuch's dystrophy, presented with redness and vision loss in her operated eye 18 months after surgery. Further clinical history revealed systemic symptoms consistent with COVID19, which had started 3 weeks prior to the onset of ocular symptoms. Examination revealed graft rejection, despite patient compliance with maintenance topical corticosteroid therapy. Serological testing was positive for SARS-CoV-2 IgG. The patient responded well to intensive treatment with systemic, periocular and topical corticosteroids, and reversal of graft rejection was achieved. Two months later, there was a recurrence of graft rejection while on maintenance therapy with cyclosporin 2% and topical corticosteroids. The same intensive immunosuppressive treatment protocol was followed, and reversal of graft rejection was again achieved. Conclusion and Importance: We believe that COVID-19 infection was a causative factor in this patient DMEK rejection. By highlighting this case, we hope to raise awareness amongst ophthalmologists of potential graft complications following COVID19 infection. |
| first_indexed | 2024-12-16T15:47:23Z |
| format | Article |
| id | doaj.art-28111604394d415e884a98cf2f6d2d90 |
| institution | Directory Open Access Journal |
| issn | 2451-9936 |
| language | English |
| last_indexed | 2024-12-16T15:47:23Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Ophthalmology Case Reports |
| spelling | doaj.art-28111604394d415e884a98cf2f6d2d902022-12-21T22:25:46ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362021-09-0123101138Descemet's membrane endothelial keratoplasty (DMEK) rejection following COVID-19 infection: A case reportKaren Bitton0Mathieu Dubois1Romain Courtin2Christophe Panthier3Damien Gatinel4Corresponding author. 29 rue Manin, 75019, Paris, France.; Department of Ophthalmology, Rothschild Foundation, Paris, FranceDepartment of Ophthalmology, Rothschild Foundation, Paris, FranceDepartment of Ophthalmology, Rothschild Foundation, Paris, FranceDepartment of Ophthalmology, Rothschild Foundation, Paris, FranceDepartment of Ophthalmology, Rothschild Foundation, Paris, FrancePurpose: To report the first known case of Descemet's Membrane Endothelial Keratoplasty (DMEK) graft rejection following COVID19 infection. Observation: A 60-year-old woman with a history of DMEK for Fuch's dystrophy, presented with redness and vision loss in her operated eye 18 months after surgery. Further clinical history revealed systemic symptoms consistent with COVID19, which had started 3 weeks prior to the onset of ocular symptoms. Examination revealed graft rejection, despite patient compliance with maintenance topical corticosteroid therapy. Serological testing was positive for SARS-CoV-2 IgG. The patient responded well to intensive treatment with systemic, periocular and topical corticosteroids, and reversal of graft rejection was achieved. Two months later, there was a recurrence of graft rejection while on maintenance therapy with cyclosporin 2% and topical corticosteroids. The same intensive immunosuppressive treatment protocol was followed, and reversal of graft rejection was again achieved. Conclusion and Importance: We believe that COVID-19 infection was a causative factor in this patient DMEK rejection. By highlighting this case, we hope to raise awareness amongst ophthalmologists of potential graft complications following COVID19 infection.http://www.sciencedirect.com/science/article/pii/S245199362100147XGraft rejectionCOVID19SARS-CoV-2Descemet’ s membrane endothelial keratoplasty (DMEK) |
| spellingShingle | Karen Bitton Mathieu Dubois Romain Courtin Christophe Panthier Damien Gatinel Descemet's membrane endothelial keratoplasty (DMEK) rejection following COVID-19 infection: A case report American Journal of Ophthalmology Case Reports Graft rejection COVID19 SARS-CoV-2 Descemet’ s membrane endothelial keratoplasty (DMEK) |
| title | Descemet's membrane endothelial keratoplasty (DMEK) rejection following COVID-19 infection: A case report |
| title_full | Descemet's membrane endothelial keratoplasty (DMEK) rejection following COVID-19 infection: A case report |
| title_fullStr | Descemet's membrane endothelial keratoplasty (DMEK) rejection following COVID-19 infection: A case report |
| title_full_unstemmed | Descemet's membrane endothelial keratoplasty (DMEK) rejection following COVID-19 infection: A case report |
| title_short | Descemet's membrane endothelial keratoplasty (DMEK) rejection following COVID-19 infection: A case report |
| title_sort | descemet s membrane endothelial keratoplasty dmek rejection following covid 19 infection a case report |
| topic | Graft rejection COVID19 SARS-CoV-2 Descemet’ s membrane endothelial keratoplasty (DMEK) |
| url | http://www.sciencedirect.com/science/article/pii/S245199362100147X |
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