Chemotherapeutic tumor microparticles combining low-dose irradiation reprogram tumor-promoting macrophages through a tumor-repopulating cell-curtailing pathway

Chemotherapeutic tumor microparticles combining low-dose irradiation reprogram tumor-promoting macrophages through a tumor-repopulating cell-curtailing pathway

Stem cell-like tumor-repopulating cells (TRCs) have a critical role in establishing a tumor immunosuppressive microenvironment. However, means to enhance antitumor immunity by disrupting TRCs are absent. Our previous studies have shown that tumor cell-derived microparticles (T-MPs) preferentially ab...

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Bibliographic Details
Main Authors: Yanling Sun, Zu'an Zheng, Huafeng Zhang, Yuandong Yu, Jingwei Ma, Ke Tang, Pingwei Xu, Tiantian Ji, Xiaoyu Liang, Degao Chen, Xun Jin, Tianzhen Zhang, Zhixiong Long, Yuying Liu, Bo Huang
Format: Article
Language:English
Published: Taylor & Francis Group 2017-06-01
Series:OncoImmunology
Subjects:
drug-packaging microparticles
low-dose irradiation
tumor-repopulating cells
macrophage remodeling
antitumor immunity
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1309487

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