Five percent weight loss is a significant 1-year predictor and an optimal 5-year cut-off for reducing the number of obesity-related cardiovascular disease risk components: the Japan Obesity and Metabolic Syndrome Study
ObjectiveThis study aimed to identify the amount of weight loss needed in patients with obesity to improve metabolic syndrome (MetS), a risk factor for cardiovascular disease (CVD), over a long period of time.MethodsA total of 576 patients with obesity were enrolled in this study. Effects of continu...
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1343153/full |
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| author | Hajime Yamakage Takaaki Jo Masashi Tanaka Masashi Tanaka Sayaka Kato Sayaka Kato Koji Hasegawa Izuru Masuda Munehide Matsuhisa Kazuhiko Kotani Mitsuhiko Noda Mitsuhiko Noda Noriko Satoh-Asahara Noriko Satoh-Asahara |
| author_facet | Hajime Yamakage Takaaki Jo Masashi Tanaka Masashi Tanaka Sayaka Kato Sayaka Kato Koji Hasegawa Izuru Masuda Munehide Matsuhisa Kazuhiko Kotani Mitsuhiko Noda Mitsuhiko Noda Noriko Satoh-Asahara Noriko Satoh-Asahara |
| author_sort | Hajime Yamakage |
| collection | DOAJ |
| description | ObjectiveThis study aimed to identify the amount of weight loss needed in patients with obesity to improve metabolic syndrome (MetS), a risk factor for cardiovascular disease (CVD), over a long period of time.MethodsA total of 576 patients with obesity were enrolled in this study. Effects of continuous physician-supervised weight loss on the cumulative MetS components excluding abdominal circumference (defined as obesity-related CVD risk score) were investigated during a 5-year follow-up period. The extent of weight loss required to reduce the obesity-related CVD risk components was assessed using receiver operating characteristic (ROC) curve analyses.ResultsOf the 576 participants, 266 completed 5-year follow-up, with 39.1% and 24.1% of them achieving ≥5.0% and ≥7.5% weight loss at the 5-year follow-up, respectively. The area under the ROC curve for reducing the obesity-related CVD risk components was 0.719 [0.662–0.777] at 1 year and 0.694 [0.613–0.775] at 5 years. The optimal cut-off value for weight loss was 5.0% (0.66 sensitivity and 0.69 specificity) and the value with 0.80 specificity was 7.5% (0.45 sensitivity) at 5 years. Greater reductions in weight were associated with greater improvements in the obesity-related CVD risk score at all follow-up periods (P-trend <0.001). Obesity-related CVD risk score was significantly improved by 5.0–7.5% and ≥7.5% weight loss at 1 year (P = 0.029 and P < 0.001, respectively) and ≥7.5% weight loss at 5 years (P = 0.034).ConclusionsA weight loss of ≥5.0% at 1 year and ≥7.5% at 5 years could reduce the number of obesity-related CVD risk components in patients with obesity. |
| first_indexed | 2024-04-24T18:41:45Z |
| format | Article |
| id | doaj.art-2811a367af4e4a28aaea18160d8fa79a |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-24T18:41:45Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-2811a367af4e4a28aaea18160d8fa79a2024-03-27T10:40:50ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-03-011510.3389/fendo.2024.13431531343153Five percent weight loss is a significant 1-year predictor and an optimal 5-year cut-off for reducing the number of obesity-related cardiovascular disease risk components: the Japan Obesity and Metabolic Syndrome StudyHajime Yamakage0Takaaki Jo1Masashi Tanaka2Masashi Tanaka3Sayaka Kato4Sayaka Kato5Koji Hasegawa6Izuru Masuda7Munehide Matsuhisa8Kazuhiko Kotani9Mitsuhiko Noda10Mitsuhiko Noda11Noriko Satoh-Asahara12Noriko Satoh-Asahara13Department of Endocrinology, Metabolism, and Hypertension Research, Clinical Research Institute, NHO Kyoto Medical Center, Kyoto, JapanDepartment of General Internal Medicine, Fushimi Momoyama General Hospital, Kyoto, JapanDepartment of Endocrinology, Metabolism, and Hypertension Research, Clinical Research Institute, NHO Kyoto Medical Center, Kyoto, JapanDepartment of Rehabilitation, Health Science University, Minamitsuru-gun, JapanDepartment of Endocrinology, Metabolism, and Hypertension Research, Clinical Research Institute, NHO Kyoto Medical Center, Kyoto, JapanDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDivision of Translational Research, Clinical Research Institute, NHO Kyoto Medical Center, Kyoto, JapanDepartment of Endocrinology, Metabolism, and Hypertension Research, Clinical Research Institute, NHO Kyoto Medical Center, Kyoto, JapanDiabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, JapanDivision of Community and Family Medicine, Jichi Medical University, Shimotsuke, JapanDepartment of Diabetes, Metabolism and Endocrinology, Ichikawa Hospital, International University of Health and Welfare, Ichikawa, JapanDepartment of Endocrinology and Diabetes, Saitama Medical University, Moroyama, JapanDepartment of Endocrinology, Metabolism, and Hypertension Research, Clinical Research Institute, NHO Kyoto Medical Center, Kyoto, Japan0Department of Metabolic Syndrome and Nutritional Science, Research Institute of Environmental Medicine, Nagoya University, Nagoya, JapanObjectiveThis study aimed to identify the amount of weight loss needed in patients with obesity to improve metabolic syndrome (MetS), a risk factor for cardiovascular disease (CVD), over a long period of time.MethodsA total of 576 patients with obesity were enrolled in this study. Effects of continuous physician-supervised weight loss on the cumulative MetS components excluding abdominal circumference (defined as obesity-related CVD risk score) were investigated during a 5-year follow-up period. The extent of weight loss required to reduce the obesity-related CVD risk components was assessed using receiver operating characteristic (ROC) curve analyses.ResultsOf the 576 participants, 266 completed 5-year follow-up, with 39.1% and 24.1% of them achieving ≥5.0% and ≥7.5% weight loss at the 5-year follow-up, respectively. The area under the ROC curve for reducing the obesity-related CVD risk components was 0.719 [0.662–0.777] at 1 year and 0.694 [0.613–0.775] at 5 years. The optimal cut-off value for weight loss was 5.0% (0.66 sensitivity and 0.69 specificity) and the value with 0.80 specificity was 7.5% (0.45 sensitivity) at 5 years. Greater reductions in weight were associated with greater improvements in the obesity-related CVD risk score at all follow-up periods (P-trend <0.001). Obesity-related CVD risk score was significantly improved by 5.0–7.5% and ≥7.5% weight loss at 1 year (P = 0.029 and P < 0.001, respectively) and ≥7.5% weight loss at 5 years (P = 0.034).ConclusionsA weight loss of ≥5.0% at 1 year and ≥7.5% at 5 years could reduce the number of obesity-related CVD risk components in patients with obesity.https://www.frontiersin.org/articles/10.3389/fendo.2024.1343153/fullobesityweight lossmetabolic syndromecohort study5-year follow-up |
| spellingShingle | Hajime Yamakage Takaaki Jo Masashi Tanaka Masashi Tanaka Sayaka Kato Sayaka Kato Koji Hasegawa Izuru Masuda Munehide Matsuhisa Kazuhiko Kotani Mitsuhiko Noda Mitsuhiko Noda Noriko Satoh-Asahara Noriko Satoh-Asahara Five percent weight loss is a significant 1-year predictor and an optimal 5-year cut-off for reducing the number of obesity-related cardiovascular disease risk components: the Japan Obesity and Metabolic Syndrome Study Frontiers in Endocrinology obesity weight loss metabolic syndrome cohort study 5-year follow-up |
| title | Five percent weight loss is a significant 1-year predictor and an optimal 5-year cut-off for reducing the number of obesity-related cardiovascular disease risk components: the Japan Obesity and Metabolic Syndrome Study |
| title_full | Five percent weight loss is a significant 1-year predictor and an optimal 5-year cut-off for reducing the number of obesity-related cardiovascular disease risk components: the Japan Obesity and Metabolic Syndrome Study |
| title_fullStr | Five percent weight loss is a significant 1-year predictor and an optimal 5-year cut-off for reducing the number of obesity-related cardiovascular disease risk components: the Japan Obesity and Metabolic Syndrome Study |
| title_full_unstemmed | Five percent weight loss is a significant 1-year predictor and an optimal 5-year cut-off for reducing the number of obesity-related cardiovascular disease risk components: the Japan Obesity and Metabolic Syndrome Study |
| title_short | Five percent weight loss is a significant 1-year predictor and an optimal 5-year cut-off for reducing the number of obesity-related cardiovascular disease risk components: the Japan Obesity and Metabolic Syndrome Study |
| title_sort | five percent weight loss is a significant 1 year predictor and an optimal 5 year cut off for reducing the number of obesity related cardiovascular disease risk components the japan obesity and metabolic syndrome study |
| topic | obesity weight loss metabolic syndrome cohort study 5-year follow-up |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1343153/full |
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