Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis
Glucocorticoids (GCs) inhibit bone angiogenesis and affect bone development, but the underlying mechanisms remain unclear. Here, the authors show that GCs induce vascular cell senescence during bone development by inhibiting angiogenin secretion from osteoclasts, impairing angiogenesis via endotheli...
Full description
Bibliographic Details
| Main Authors: |
Xiaonan Liu,
Yu Chai,
Guanqiao Liu,
Weiping Su,
Qiaoyue Guo,
Xiao Lv,
Peisong Gao,
Bin Yu,
Gerardo Ferbeyre,
Xu Cao,
Mei Wan |
|---|
| Format: | Article
|
|---|
| Language: | English |
|---|
| Published: |
Nature Portfolio
2021-03-01
|
|---|
| Series: | Nature Communications
|
|---|
| Online Access: | https://doi.org/10.1038/s41467-021-22131-1
|
|---|