Emerging biomedical imaging-based companion diagnostics for precision medicine
Summary: The tumor heterogeneity, which leads to individual variations in tumor microenvironments, causes poor prognoses and limits therapeutic response. Emerging technology such as companion diagnostics (CDx) detects biomarkers and monitors therapeutic responses, allowing identification of patients...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-08-01
|
| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223013548 |
| _version_ | 1797780002173878272 |
|---|---|
| author | Shiyi Liao Mengjie Zhou Youjuan Wang Chang Lu Baoli Yin Ying Zhang Huiyi Liu Xia Yin Guosheng Song |
| author_facet | Shiyi Liao Mengjie Zhou Youjuan Wang Chang Lu Baoli Yin Ying Zhang Huiyi Liu Xia Yin Guosheng Song |
| author_sort | Shiyi Liao |
| collection | DOAJ |
| description | Summary: The tumor heterogeneity, which leads to individual variations in tumor microenvironments, causes poor prognoses and limits therapeutic response. Emerging technology such as companion diagnostics (CDx) detects biomarkers and monitors therapeutic responses, allowing identification of patients who would benefit most from treatment. However, currently, most US Food and Drug Administration-approved CDx tests are designed to detect biomarkers in vitro and ex vivo, making it difficult to dynamically report variations of targets in vivo. Various medical imaging techniques offer dynamic measurement of tumor heterogeneity and treatment response, complementing CDx tests. Imaging-based companion diagnostics allow for patient stratification for targeted medicines and identification of patient populations benefiting from alternative therapeutic methods. This review summarizes recent developments in molecular imaging for predicting and assessing responses to cancer therapies, as well as the various biomarkers used in imaging-based CDx tests. We hope this review provides informative insights into imaging-based companion diagnostics and advances precision medicine. |
| first_indexed | 2024-03-12T23:38:29Z |
| format | Article |
| id | doaj.art-2813c24dc9924f8c8063e7ef30163e26 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-12T23:38:29Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-2813c24dc9924f8c8063e7ef30163e262023-07-15T04:29:07ZengElsevieriScience2589-00422023-08-01268107277Emerging biomedical imaging-based companion diagnostics for precision medicineShiyi Liao0Mengjie Zhou1Youjuan Wang2Chang Lu3Baoli Yin4Ying Zhang5Huiyi Liu6Xia Yin7Guosheng Song8State Key Laboratory for Chemo, Biosensing and Chemometrics, College of Chemistry and Chemical, Engineering, Hunan University, Changsha 410082, ChinaState Key Laboratory for Chemo, Biosensing and Chemometrics, College of Chemistry and Chemical, Engineering, Hunan University, Changsha 410082, ChinaState Key Laboratory for Chemo, Biosensing and Chemometrics, College of Chemistry and Chemical, Engineering, Hunan University, Changsha 410082, ChinaState Key Laboratory for Chemo, Biosensing and Chemometrics, College of Chemistry and Chemical, Engineering, Hunan University, Changsha 410082, ChinaState Key Laboratory for Chemo, Biosensing and Chemometrics, College of Chemistry and Chemical, Engineering, Hunan University, Changsha 410082, ChinaState Key Laboratory for Chemo, Biosensing and Chemometrics, College of Chemistry and Chemical, Engineering, Hunan University, Changsha 410082, ChinaState Key Laboratory for Chemo, Biosensing and Chemometrics, College of Chemistry and Chemical, Engineering, Hunan University, Changsha 410082, ChinaState Key Laboratory for Chemo, Biosensing and Chemometrics, College of Chemistry and Chemical, Engineering, Hunan University, Changsha 410082, ChinaState Key Laboratory for Chemo, Biosensing and Chemometrics, College of Chemistry and Chemical, Engineering, Hunan University, Changsha 410082, China; Corresponding authorSummary: The tumor heterogeneity, which leads to individual variations in tumor microenvironments, causes poor prognoses and limits therapeutic response. Emerging technology such as companion diagnostics (CDx) detects biomarkers and monitors therapeutic responses, allowing identification of patients who would benefit most from treatment. However, currently, most US Food and Drug Administration-approved CDx tests are designed to detect biomarkers in vitro and ex vivo, making it difficult to dynamically report variations of targets in vivo. Various medical imaging techniques offer dynamic measurement of tumor heterogeneity and treatment response, complementing CDx tests. Imaging-based companion diagnostics allow for patient stratification for targeted medicines and identification of patient populations benefiting from alternative therapeutic methods. This review summarizes recent developments in molecular imaging for predicting and assessing responses to cancer therapies, as well as the various biomarkers used in imaging-based CDx tests. We hope this review provides informative insights into imaging-based companion diagnostics and advances precision medicine.http://www.sciencedirect.com/science/article/pii/S2589004223013548DiagnosticsBiomedical engineering |
| spellingShingle | Shiyi Liao Mengjie Zhou Youjuan Wang Chang Lu Baoli Yin Ying Zhang Huiyi Liu Xia Yin Guosheng Song Emerging biomedical imaging-based companion diagnostics for precision medicine iScience Diagnostics Biomedical engineering |
| title | Emerging biomedical imaging-based companion diagnostics for precision medicine |
| title_full | Emerging biomedical imaging-based companion diagnostics for precision medicine |
| title_fullStr | Emerging biomedical imaging-based companion diagnostics for precision medicine |
| title_full_unstemmed | Emerging biomedical imaging-based companion diagnostics for precision medicine |
| title_short | Emerging biomedical imaging-based companion diagnostics for precision medicine |
| title_sort | emerging biomedical imaging based companion diagnostics for precision medicine |
| topic | Diagnostics Biomedical engineering |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223013548 |
| work_keys_str_mv | AT shiyiliao emergingbiomedicalimagingbasedcompaniondiagnosticsforprecisionmedicine AT mengjiezhou emergingbiomedicalimagingbasedcompaniondiagnosticsforprecisionmedicine AT youjuanwang emergingbiomedicalimagingbasedcompaniondiagnosticsforprecisionmedicine AT changlu emergingbiomedicalimagingbasedcompaniondiagnosticsforprecisionmedicine AT baoliyin emergingbiomedicalimagingbasedcompaniondiagnosticsforprecisionmedicine AT yingzhang emergingbiomedicalimagingbasedcompaniondiagnosticsforprecisionmedicine AT huiyiliu emergingbiomedicalimagingbasedcompaniondiagnosticsforprecisionmedicine AT xiayin emergingbiomedicalimagingbasedcompaniondiagnosticsforprecisionmedicine AT guoshengsong emergingbiomedicalimagingbasedcompaniondiagnosticsforprecisionmedicine |