Dexmedetomidine ameliorates high glucose-induced epithelial-mesenchymal transformation in HK-2 cells through the Cdk5/Drp1/ROS pathway

Dexmedetomidine ameliorates high glucose-induced epithelial-mesenchymal transformation in HK-2 cells through the Cdk5/Drp1/ROS pathway

Epithelial-mesenchymal transformation (EMT) plays an important role in the progression of diabetic nephropathy. Dexmedetomidine (DEX) has shown renoprotective effects against ischemic reperfusion injury; however, whether and how DEX prevents high glucose-induced EMT in renal tubular epithelial cells...

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Bibliographic Details
Main Authors: Wang Fei, Xu Weilong, Liu Xiaoge, Zhang Jun
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2023-11-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
dexmedetomidine
high glucose
epithelial-mesenchymal transformation
cyclin-dependent kinase 5
dynamin-related protein 1
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2023220

Internet

https://www.sciengine.com/doi/10.3724/abbs.2023220

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